公开(公告)号：US08415462B2

公开(公告)日：2013-04-09

申请号：US12600460

申请日：2008-01-29

申请人： Nathalie Sylvestre ,  Eric Jacobs

发明人： Nathalie Sylvestre ,  Eric Jacobs

IPC分类号： C07H21/04 ,  C12N15/00 ,  C12Q1/00 ,  C12P21/06

CPC分类号： C12N15/85 ,  C07K14/005 ,  C07K2319/02 ,  C07K2319/03 ,  C12N2760/20122 ,  C12N2840/20

摘要： The present invention provides novel peptides of specified sequence and their use as a signal peptide or a membrane-anchoring peptide. It also relates to chimeric polypeptide comprising one or more such peptides and a polypeptide of interest as well as nucleic acid molecules, vectors, infections vital particles and host cells encoding such peptides and chimeric polypeptides. The present invention also relates to a pharmaceutical composition comprising such elements and a pharmaceutically acceptable vehicle. The present invention also provides a method for recumbently producing a polypeptide using such peptides, especially for directing expression of a polypeptide of interest extracellularly or anchored at the surface of the plasma membrane.

摘要翻译： 本发明提供具有特定序列的新型肽及其作为信号肽或膜 - 锚定肽的用途。 它还涉及包含一种或多种此类肽和感兴趣多肽以及核酸分子，载体，感染重要颗粒和编码这些肽和嵌合多肽的宿主细胞的嵌合多肽。 本发明还涉及包含这些元件和药学上可接受的载体的药物组合物。 本发明还提供了一种使用这些肽沉降产生多肽的方法，特别是用于引导细胞外或锚定在质膜表面的感兴趣多肽的表达。