公开(公告)号：US07517342B2

公开(公告)日：2009-04-14

申请号：US10425170

申请日：2003-04-29

申请人： Neal Scott ,  Jerome Segal ,  Lih-Bin Shih ,  Terry L. Burkoth

发明人： Neal Scott ,  Jerome Segal ,  Lih-Bin Shih ,  Terry L. Burkoth

IPC分类号： A61B17/20

CPC分类号： A61N1/325 ,  A61N1/306

摘要： The present invention relates to a catheter with an expandable distal end for delivering one or more medicaments. The catheter is manufactured with materials of construction that allow the transfer of electrical energy from the proximal end of the catheter to the distal expandable end. The catheter also has a means for controlling or manipulating the expandable distal end to expand and contract into various configurations. The distal end of the catheter is processed by a specific method of manufacturing whereby the expandable distal end is coated with one or more layers of a hydrogel copolymer wherein at least one layer of which coating encapsulates one or more medicaments and zero or more charged carriers to facilitate the electrophoretic and electro-osmostic mobilities of the medicaments.

摘要翻译： 本发明涉及具有用于递送一种或多种药物的可扩展远端的导管。 该导管由构造材料制成，其允许将电能从导管的近端传递到远端可扩展端。 导管还具有用于控制或操纵可扩展远端以扩展和收缩成各种构造的装置。 导管的远端通过具体的制造方法进行处理，由此可扩展的远端涂覆有一层或多层水凝胶共聚物，其中至少一层涂层将一种或多种药物和零个或多个带电载体包封， 促进药物的电泳和电渗析迁移率。

公开(公告)号：US20050054978A1

公开(公告)日：2005-03-10

申请号：US10951232

申请日：2004-09-27

申请人： Jerome Segal ,  Neal Scott

发明人： Jerome Segal ,  Neal Scott

IPC分类号： A61M29/00 ,  A61M29/02 ,  A61N1/30

CPC分类号： A61M29/02 ,  A61M2025/0004 ,  A61M2025/0008 ,  A61M2025/0175 ,  A61M2025/0183 ,  A61M2025/105 ,  A61N1/306

摘要： A mechanical dilatation and medicament delivery device for enlarging a flow passage of a vessel by dilating and delivering a therapeutic agent or medicament to an obstruction in the vessel. The present invention comprises a substantially cylindrically shaped expansion member and includes a means engaged to the expansion member for altering the distance between the proximal end and the distal end of the expansion member thereby transforming the expansion member between a diametrically contracted configuration to diametrically expanded configuration. A therapeutic agent or medicament is coated on either the expansion member, or incorporated into an substrate and then coated on the expansion member.

摘要翻译： 一种机械扩张和药物输送装置，用于通过将治疗剂或药物扩张并输送到容器中的阻塞物来扩大血管的流动通道。 本发明包括一个基本上圆柱形的膨胀件，它包括一个与膨胀件接合的装置，用于改变膨胀件的近端和远端之间的距离，从而使膨胀件在直径收缩构型之间转变为直径扩大的构型。 将治疗剂或药物涂覆在膨胀构件上，或者结合到基底中，然后涂覆在膨胀构件上。

公开(公告)号：US20050043680A1

公开(公告)日：2005-02-24

申请号：US10951964

申请日：2004-09-28

申请人： Jerome Segal ,  Neal Scott

发明人： Jerome Segal ,  Neal Scott

IPC分类号： A61M29/00 ,  A61M29/02 ,  A61N1/30

CPC分类号： A61M29/02 ,  A61M2025/0004 ,  A61M2025/0008 ,  A61M2025/0175 ,  A61M2025/0183 ,  A61M2025/105 ,  A61N1/306

摘要： A mechanical dilatation and medicament delivery device for enlarging a flow passage of a vessel by dilating and delivering a charged paclitaxel analogue therapeutic agent or medicament to an obstruction in the vessel. The present invention comprises a substantially cylindrically shaped expansion member and includes a means engaged to the expansion member for altering the distance between the proximal end and the distal end of the expansion member thereby transforming the expansion member between a diametrically contracted configuration to diametrically expanded configuration. A charged paclitaxel analogue therapeutic agent or medicament is coated on either the expansion member, or combined/incorporated into a substrate coated on the expansion member. The present method comprises the steps of advancing the coated expansion member to the obstruction in a vessel and applying opposed forces on said expansion member in an axial direction to move the expansion member to an expanded configuration wherein the expansion member dilates the obstruction and the expansion member either passively or actively delivers a charged paclitaxel analogue therapeutic agent or medicament to the obstruction.

摘要翻译： 一种机械扩张和药物输送装置，用于通过将带电的紫杉醇类似物治疗剂或药物扩张并输送到血管中的阻塞物来扩大血管的流动通道。 本发明包括一个基本上圆柱形的膨胀件，它包括一个与膨胀件接合的装置，用于改变膨胀件的近端和远端之间的距离，从而使膨胀件在直径收缩构型之间转变为直径扩大的构型。 将带电的紫杉醇类似物治疗剂或药物涂覆在扩张构件上，或者组合/结合到涂覆在扩张构件上的基底中。 本发明的方法包括以下步骤：将涂覆的膨胀构件推进到容器中的障碍物上，并在轴向上在所述膨胀构件上施加相对的力以将膨胀构件移动到膨胀构件，其中膨胀构件使阻塞膨胀和膨胀构件 被动地或主动地将带电的紫杉醇类似物治疗剂或药物递送至阻塞物。

公开(公告)号：US07519418B2

公开(公告)日：2009-04-14

申请号：US10865222

申请日：2004-06-10

申请人： Neal Scott ,  Jerome Segal

发明人： Neal Scott ,  Jerome Segal

IPC分类号： A61N1/30

CPC分类号： A61M29/02 ,  A61M2025/0057 ,  A61M2025/105

摘要： An apparatus for delivering a medicament, such as a liposome or micelle-encapsulated therapeutic agent or medicament, to an obstruction within a vascular segment or a body passageway. The apparatus may include a substantially cylindrically shaped expansion member. A distance between the proximal and distal ends of the expansion member may be altered to transform the expansion member between a diametrically contracted configuration to a diametrically expanded configuration. The liposome or micelle-encapsulated therapeutic agent or medicament can be coated on the expansion member and/or incorporated into a substrate coated on the expansion member.

摘要翻译： 用于将药物（例如脂质体或胶束包封的治疗剂或药物）递送到血管段或身体通道内的阻塞物的装置。 该装置可以包括基本上圆柱形的膨胀构件。 可以改变膨胀构件的近端和远端之间的距离，以使膨胀构件在直径收缩构型之间转变成直径扩张构型。 脂质体或胶束包封的治疗剂或药物可以涂覆在膨胀构件上和/或结合到涂覆在膨胀构件上的基底中。

公开(公告)号：US20050159704A1

公开(公告)日：2005-07-21

申请号：US11027336

申请日：2004-12-30

申请人： Neal Scott ,  Terry Burkoth ,  Scott Harris

发明人： Neal Scott ,  Terry Burkoth ,  Scott Harris

IPC分类号： A61M29/00 ,  A61M29/02 ,  A61N1/30 ,  A61M31/00

CPC分类号： A61M29/02 ,  A61M2025/0004 ,  A61M2025/0008 ,  A61M2025/0175 ,  A61M2025/0183 ,  A61M2025/105 ,  A61N1/306

摘要： The present invention relates to a catheter with an expandable distal end for delivering one or more medicaments. The catheter also has a means for controlling or manipulating the expandable distal end to expand and contract into various configurations to apply pressure and achieve good contact against the walls of structures into which it is advanced. The distal end of the catheter is processed by a specific method of manufacturing whereby the expandable distal end is coated with one or more layers of a polymer wherein the surface layer of which coating carries one or more medicaments at very high concentration and zero or more excipients to facilitate the diffusional penetration of the medicaments into contacted tissues.

摘要翻译： 本发明涉及具有用于递送一种或多种药物的可扩展远端的导管。 导管还具有用于控制或操纵可膨胀远端以膨胀和收缩成各种构造以施加压力并实现与其前进的结构的良好接触的装置。 导管的远端通过具体的制造方法进行处理，由此可扩展的远端涂覆有一层或多层聚合物，其中涂层的表面层含有非常高浓度的一种或多种药物和零或更多的赋形剂 以促进药物在接触组织中的扩散渗透。

公开(公告)号：US10661055B1

公开(公告)日：2020-05-26

申请号：US16706338

申请日：2019-12-06

申请人： Neal Scott

发明人： Neal Scott

IPC分类号： A61M25/00 ,  A61N1/32 ,  A61N1/04 ,  A61M25/01

摘要： A device and method of treating proliferative disorders such as pancreatic cancer are described. Devices comprise an expandable mesh with two axial wings that seal against the inside of an enclosing blood vessel, creating an enclosed diffusion volume in the area subtended by the wings while permitting normal flow in the blood vessel through the ends of the mesh. A coaxial lumen provides for a guide wire, treatment drug tube, one or more flexible hypotubes and optionally electrical wires. The diffusion volume is set by the angle subtended by the wings causing the drug delivery to be radically directed toward a targeted tumor. Iontophoresis and electroporation electrodes on the mesh are used to directionally drive the drug through adjacent tissue and to temporarily increase the permeability of tissue through which the drug flows.

公开(公告)号：US07488314B2

公开(公告)日：2009-02-10

申请号：US10950606

申请日：2004-09-27

申请人： Jerome Segal ,  Neal Scott

发明人： Jerome Segal ,  Neal Scott

IPC分类号： A61M31/00

CPC分类号： A61M29/02 ,  A61M2025/0004 ,  A61M2025/0008 ,  A61M2025/0175 ,  A61M2025/0183 ,  A61M2025/105 ,  A61N1/306

摘要： The present method comprises the steps of advancing the coated expansion member to the obstruction in a vessel and applying opposed forces on said expansion member in an axial direction to move the expansion member to an expanded configuration wherein the expansion member dilates the obstruction and the expansion member either passively or actively delivers a therapeutic agent or medicament to the obstruction.

摘要翻译： 本发明的方法包括以下步骤：将涂覆的膨胀构件推进到容器中的障碍物上，并在轴向上在所述膨胀构件上施加相对的力以将膨胀构件移动到膨胀构件，其中膨胀构件使阻塞膨胀和膨胀构件 被动地或主动地将治疗剂或药物输送到阻塞物。

公开(公告)号：US07292885B2

公开(公告)日：2007-11-06

申请号：US10135709

申请日：2002-04-30

申请人： Neal Scott ,  Jerome Segal

发明人： Neal Scott ,  Jerome Segal

IPC分类号： A61N1/30 ,  A61M29/00

CPC分类号： A61M29/02 ,  A61M2025/0004 ,  A61M2025/0008 ,  A61M2025/0175 ,  A61M2025/0183 ,  A61M2025/105 ,  A61N1/306

摘要： A mechanical dilatation and medicament delivery device for enlarging a flow passage of a vessel by dilating and delivering a liposome or micelle-encapsulated therapeutic agent or medicament to an obstruction in the vessel. The present invention comprises a substantially cylindrically shaped expansion member and includes a means engaged to the expansion member for altering the distance between the proximal end and the distal end of the expansion member thereby transforming the expansion member between a diametrically contracted configuration to diametrically expanded configuration. A liposome or micelle-encapsulated therapeutic agent or medicament is coated on either the expansion member, or incorporated into a substrate coated on the expansion member.

摘要翻译： 一种机械扩张和药物输送装置，用于通过将脂质体或胶束包封的治疗剂或药物扩散并输送到血管中的阻塞物来扩大血管的流动通道。 本发明包括一个基本圆柱形的膨胀件，它包括一个与膨胀件啮合的装置，用于改变膨胀件的近端和远端之间的距离，从而使膨胀件在直径收缩构型和直径膨胀构型之间变换。 将脂质体或胶束包封的治疗剂或药物涂覆在膨胀构件上，或者包含在涂覆在膨胀构件上的基底中。

公开(公告)号：US20050240145A1

公开(公告)日：2005-10-27

申请号：US10865221

申请日：2004-06-10

申请人： Neal Scott ,  Jerome Segal

发明人： Neal Scott ,  Jerome Segal

IPC分类号： A61F2/06 ,  A61M25/00 ,  A61M29/02 ,  A61N1/30

CPC分类号： A61M29/02 ,  A61M2025/0057 ,  A61M2025/105

摘要： A mechanical dilatation and medicament delivery device for enlarging a flow passage of a vessel by dilating and delivering a liposome or micelle-encapsulated therapeutic agent or medicament to an obstruction in the vessel. The present invention comprises a substantially cylindrically shaped expansion member and includes a means engaged to the expansion member for altering the distance between the proximal end and the distal end of the expansion member thereby transforming the expansion member between a diametrically contracted configuration to diametrically expanded configuration. A liposome or micelle-encapsulated therapeutic agent or medicament is coated on either the expansion member, or incorporated into a substrate coated on the expansion member. The present method comprises the steps of advancing the coated expansion member to the obstruction in a vessel and applying opposed forces on said expansion member in an axial direction to move the expansion member to an expanded configuration wherein the expansion member dilates the obstruction and the expansion member either passively or actively delivers a liposome or micelle-encapsulated therapeutic agent or medicament to the obstruction.

摘要翻译： 一种机械扩张和药物输送装置，用于通过将脂质体或胶束包封的治疗剂或药物扩散并输送到血管中的阻塞物来扩大血管的流动通道。 本发明包括一个基本上圆柱形的膨胀件，它包括一个与膨胀件接合的装置，用于改变膨胀件的近端和远端之间的距离，从而使膨胀件在直径收缩构型之间转变为直径扩大的构型。 将脂质体或胶束包封的治疗剂或药物涂覆在膨胀构件上，或者包含在涂覆在膨胀构件上的基底中。 本发明的方法包括以下步骤：将涂覆的膨胀构件推进到容器中的障碍物上，并在轴向上在所述膨胀构件上施加相对的力以将膨胀构件移动到膨胀构件，其中膨胀构件使阻塞膨胀和膨胀构件 被动地或主动地将脂质体或胶束包封的治疗剂或药物递送至阻塞物。

公开(公告)号：US20050038409A1

公开(公告)日：2005-02-17

申请号：US10950606

申请日：2004-09-27

申请人： Jerome Segal ,  Neal Scott

发明人： Jerome Segal ,  Neal Scott

IPC分类号： A61M29/00 ,  A61M29/02 ,  A61N1/30 ,  A61M31/00

CPC分类号： A61M29/02 ,  A61M2025/0004 ,  A61M2025/0008 ,  A61M2025/0175 ,  A61M2025/0183 ,  A61M2025/105 ,  A61N1/306

摘要： The present method comprises the steps of advancing the coated expansion member to the obstruction in a vessel and applying opposed forces on said expansion member in an axial direction to move the expansion member to an expanded configuration wherein the expansion member dilates the obstruction and the expansion member either passively or actively delivers a therapeutic agent or medicament to the obstruction.

摘要翻译： 本发明的方法包括以下步骤：将涂覆的膨胀构件推进到容器中的障碍物上，并在轴向上在所述膨胀构件上施加相对的力以将膨胀构件移动到膨胀构件，其中膨胀构件使阻塞膨胀和膨胀构件 被动地或主动地将治疗剂或药物输送到阻塞物。