公开(公告)号：US20070135382A1

公开(公告)日：2007-06-14

申请号：US10576824

申请日：2004-10-22

申请人： Richard Phipps ,  Patricia Sime ,  Neil Blumberg

发明人： Richard Phipps ,  Patricia Sime ,  Neil Blumberg

IPC分类号： A61K31/685 ,  A61K31/557 ,  A61K31/426 ,  A61K31/198 ,  A61K31/17

CPC分类号： A61K31/426 ,  A61K31/00 ,  A61K31/17 ,  A61K31/198 ,  A61K31/421 ,  A61K31/557 ,  A61K31/685 ,  A61K38/1709 ,  A61K45/06 ,  A61K2300/00

摘要： Methods of inhibiting mammalian platelet release of CD40 ligand, thromboxanes, or prostaglandin E2, or surface expression of CD40 ligand that involve contacting mammalian platelets with an effective amount of a PPARγ agonist, an RXR agonist, or a combination thereof. As a consequence of inhibiting CD40 ligand and thromboxane release, the present invention allows for inhibition of thrombus fon-nation by (or clotting activities of) activated platelets, as well as treating or preventing CD40 ligand-mediated conditions and/or thromboxane-mediated conditions. Use of PPARγ agonist, RXR agonist, and/or inducers of PPARγ agonist in preparing a stored blood product, and for diagnostic testing of patient samples is also disclosed.

摘要翻译： 抑制CD40配体，血栓素或前列腺素E2的哺乳动物血小板释放或CD40配体的表面表达的方法，其涉及将哺乳动物血小板与有效量的PPARγ激动剂，RXR激动剂或其组合接触。 作为抑制CD40配体和血栓素释放的结果，本发明允许通过活化血小板的（或凝血活性）抑制血栓形成，以及治疗或预防CD40配体介导的病症和/或血栓烷介导的病症 。 还公开了PPARγ激动剂，RXR激动剂和/或PPARγ激动剂诱导剂在制备储存的血液制品中的用途以及用于患者样品的诊断测试。