公开(公告)号：US4725621A

公开(公告)日：1988-02-16

申请号：US835825

申请日：1986-03-03

申请人： Richard H. Bunge ,  James C. French ,  Timothy R. Hurley ,  Neil E. Willmer

发明人： Richard H. Bunge ,  James C. French ,  Timothy R. Hurley ,  Neil E. Willmer

IPC分类号： C07D309/30 ,  A61K31/365

CPC分类号： C07D309/30

摘要： A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the antimicrobial compound CL-1957E which also exhibits antitumor properties.The antimicrobial compound CL-1957E is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantially quantity of the CL-1957E compound is produced, and subsequently isolating the CL-1957E compound.The antibiotic compound CL-1957E and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.

摘要翻译： 确定为ATCC 39366的放线菌的纯化分离物能够生产也具有抗肿瘤性质的抗微生物化合物CL-1957E。 抗微生物化合物CL-1957E是通过在需氧条件下培养含有可同化碳源和氮源的培养基中分离的ATCC 39366产生的，直到产生大量的CL-1957E化合物，然后分离出CL-1957E化合物。 还公开了抗生素化合物CL-1957E和包含该物质的药物组合物与药学上可接受的载体，以及使用这些药物组合物治疗哺乳动物的微生物感染和肿瘤的方法。

公开(公告)号：US4696794A

公开(公告)日：1987-09-29

申请号：US928443

申请日：1986-11-07

申请人： Richard H. Bunge ,  James C. French ,  Timothy R. Hurley ,  Neil E. Willmer

发明人： Richard H. Bunge ,  James C. French ,  Timothy R. Hurley ,  Neil E. Willmer

IPC分类号： C12P1/06 ,  A61K35/74 ,  C12D1/06

CPC分类号： C12P1/06

摘要： A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the antimicrobial compound CL-1957D.The antimicrobial compound CL-1957D is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957D compound is produced, and subsequently isolating the CL-1957D compound.The antibiotic compound CL-1957D and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections in mammals, employing these pharmaceutical compositions.

摘要翻译： 确定为ATCC 39366的放线菌的纯化分离物能够产生抗微生物化合物CL-1957D。 抗微生物化合物CL-1957D是通过在需氧条件下培养含有可同化碳源和氮源的培养基中分离的ATCC 39366产生的，直到产生大量的CL-1957D化合物，然后分离出CL-1957D化合物。 还公开了抗生素化合物CL-1957D和包含该物质的药物组合物与药学上可接受的载体，以及使用这些药物组合物治疗哺乳动物微生物感染的方法。