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    CL-1957E antibiotic compound and its production
    1.
    发明授权
    CL-1957E antibiotic compound and its production 失效
    CL-1957E抗生素化合物及其生产

    公开(公告)号：US4725621A

    公开(公告)日：1988-02-16

    申请号：US835825

    申请日：1986-03-03

    申请人： Richard H. Bunge ,  James C. French ,  Timothy R. Hurley ,  Neil E. Willmer

    发明人： Richard H. Bunge ,  James C. French ,  Timothy R. Hurley ,  Neil E. Willmer

    IPC分类号： C07D309/30 ,  A61K31/365

    CPC分类号： C07D309/30

    摘要： A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the antimicrobial compound CL-1957E which also exhibits antitumor properties.The antimicrobial compound CL-1957E is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantially quantity of the CL-1957E compound is produced, and subsequently isolating the CL-1957E compound.The antibiotic compound CL-1957E and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.

    摘要翻译： 确定为ATCC 39366的放线菌的纯化分离物能够生产也具有抗肿瘤性质的抗微生物化合物CL-1957E。 抗微生物化合物CL-1957E是通过在需氧条件下培养含有可同化碳源和氮源的培养基中分离的ATCC 39366产生的，直到产生大量的CL-1957E化合物，然后分离出CL-1957E化合物。 还公开了抗生素化合物CL-1957E和包含该物质的药物组合物与药学上可接受的载体，以及使用这些药物组合物治疗哺乳动物的微生物感染和肿瘤的方法。

    CL-1957D antibiotic compound and its production
    2.
    发明授权
    CL-1957D antibiotic compound and its production 失效
    CL-1957D抗生素复方及其生产

    公开(公告)号：US4696794A

    公开(公告)日：1987-09-29

    申请号：US928443

    申请日：1986-11-07

    申请人： Richard H. Bunge ,  James C. French ,  Timothy R. Hurley ,  Neil E. Willmer

    发明人： Richard H. Bunge ,  James C. French ,  Timothy R. Hurley ,  Neil E. Willmer

    IPC分类号： C12P1/06 ,  A61K35/74 ,  C12D1/06

    CPC分类号： C12P1/06

    摘要： A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the antimicrobial compound CL-1957D.The antimicrobial compound CL-1957D is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957D compound is produced, and subsequently isolating the CL-1957D compound.The antibiotic compound CL-1957D and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections in mammals, employing these pharmaceutical compositions.

    摘要翻译： 确定为ATCC 39366的放线菌的纯化分离物能够产生抗微生物化合物CL-1957D。 抗微生物化合物CL-1957D是通过在需氧条件下培养含有可同化碳源和氮源的培养基中分离的ATCC 39366产生的，直到产生大量的CL-1957D化合物，然后分离出CL-1957D化合物。 还公开了抗生素化合物CL-1957D和包含该物质的药物组合物与药学上可接受的载体，以及使用这些药物组合物治疗哺乳动物微生物感染的方法。

    CL-1577 Antibiotic compounds and their production
    4.
    发明授权
    CL-1577 Antibiotic compounds and their production 失效
    CL-1577抗生素化合物及其生产

    公开(公告)号：US4530835A

    公开(公告)日：1985-07-23

    申请号：US512088

    申请日：1983-07-08

    申请人： Richard H. Bunge ,  James C. French ,  Timothy R. Hurley ,  Tim A. Smitka ,  Josefino B. Tunac

    发明人： Richard H. Bunge ,  James C. French ,  Timothy R. Hurley ,  Tim A. Smitka ,  Josefino B. Tunac

    IPC分类号： A61K35/74 ,  A61P31/04 ,  A61P35/00 ,  C07G11/00 ,  C12N1/20 ,  C12P1/06 ,  C12R1/465

    CPC分类号： C12P1/06

    摘要： A purified isolate of an actinomycete identified as ATCC 39363 is capable of producing a complex of sulfur-containing antibiotic compounds having activity against transplanted tumors.Antibiotic compounds CL-1577A and CL-1577B and their closely related congeners are produced by cultivating isolate ATCC 39363 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1577 complex is produced, and subsequently isolating the complex or one or more of the compounds.The antibiotic compounds CL-1577A, CL-1577B, their congeners, and pharmaceutical compositions comprising these substances together with a suitable carrier are also disclosed.

    摘要翻译： 确定为ATCC 39363的放线菌的纯化分离物能够产生具有针对移植肿瘤的活性的含硫抗生素化合物的复合物。 抗生素化合物CL-1577A和CL-1577B及其密切相关的同系物通过在需氧条件下培养分离物ATCC 39363，在含有可同化碳源和氮的来源的培养基中培养，直到产生大量的CL-1577复合物，随后 分离复合物或一种或多种化合物。 还公开了抗生素化合物CL-1577A，CL-1577B，它们的同系物和包含这些物质的药物组合物和合适的载体。

    Dimeric Oxidation-Resistant Apolipoprotein A1 Variants
    7.
    发明申请
    Dimeric Oxidation-Resistant Apolipoprotein A1 Variants 审中-公开
    二聚抗氧化载脂蛋白A1变体

    公开(公告)号：US20130137628A1

    公开(公告)日：2013-05-30

    申请号：US13697251

    申请日：2011-05-11

    申请人： Roger S. Newton ,  Rai Ajit K. Srivastava ,  Timothy R. Hurley ,  Clay Cramer ,  Sergey V. Filippov ,  Stephen L. Pinkosky

    发明人： Roger S. Newton ,  Rai Ajit K. Srivastava ,  Timothy R. Hurley ,  Clay Cramer ,  Sergey V. Filippov ,  Stephen L. Pinkosky

    IPC分类号： C07K14/775

    CPC分类号： C07K14/775 ,  A61K38/00

    摘要： An isolated oxidation-resistant ApoA1 variant dimer includes a first oxidation-resistant ApoA1 variant polypeptide monomer and a second oxidation-resistant ApoA1 variant polypeptide monomer, wherein at least one of the first and the second monomers comprises at least one amino acid substitution of a tryptophan residue for an oxidation resistant amino acid, or a functional fragment or variant thereof. Methods for treating a disease or disorder comprises administering to a subject in need thereof, a therapeutically effective amount of an isolated oxidation-resistant ApoA1 variant dimer, an oxidation-resistant ApoA1 variant monomer, an oxidation-resistant ApoA1 monomer-lipid complex, a lipid complexed oxidation-resistant ApoA1 variant monomer, a lipid complexed oxidation-resistant ApoA1 variant dimer, or combinations thereof to the subject to enhance cholesterol efflux activity in the presence of an oxidant.

    摘要翻译： 分离的抗氧化ApoA1变体二聚体包括第一抗氧化ApoA1变体多肽单体和第二抗氧化ApoA1变体多肽单体，其中第一和第二单体中的至少一个包含至少一个色氨酸的氨基酸取代 用于抗氧化氨基酸的残基或其功能片段或变体。 用于治疗疾病或病症的方法包括向有需要的受试者施用治疗有效量的分离的抗氧化ApoA1变体二聚体，抗氧化ApoA1变体单体，抗氧化ApoA1单体 - 脂质复合物，脂质 复合抗氧化ApoA1变体单体，脂质复合抗氧化ApoA1变体二聚体或其组合，以增强氧化剂存在下的胆固醇流出活性。

    MOUNTABLE HAND SANITIZER STATION
    8.
    发明申请
    MOUNTABLE HAND SANITIZER STATION 审中-公开
    手提桑拿电台

    公开(公告)号：US20110155766A1

    公开(公告)日：2011-06-30

    申请号：US12979791

    申请日：2010-12-28

    申请人： Timothy R. Hurley

    发明人： Timothy R. Hurley

    IPC分类号： B67D7/84

    CPC分类号： A47K5/12

    摘要： A portable hand sanitizing station that is adapted for mounting on a variety of supporting surfaces is disclosed. A main hand sanitizing station body has a housing that includes a re-fillable reservoir for receiving and containing a hand sanitizing substance, a downwardly projecting sanitizer dispensing outlet, and a manually actuated trigger for controlled dispensing of hand sanitizing substance from the reservoir through the dispensing outlet. A clamp allows the hand sanitizing station body to be removably affixed to a supporting surface, such as the edge of a table or the like. The clamp is preferably configured to allow the hand sanitizing station to be removably mounted to the edge of a horizontally disposed surface, and alternately to the edge of a vertically disposed surface. By providing a portable hand sanitizing station that may be removably mounted to a supporting structure, the present invention provides a hand sanitizer apparatus that may be quickly and easily deployed in the field to provide a temporary hand sanitizing station capable of dispensing a significant quantity of hand sanitizer.

    摘要翻译： 公开了适于安装在各种支撑表面上的便携式手部消毒站。 主要消毒站主体具有壳体，该壳体包括用于接收和容纳手消毒物质的可重新填充的储存器，向下突出的消毒剂分配出口以及手动致动的触发器，用于通过分配从储存器控制分配手部消毒物质 出口。 夹具允许手部消毒站主体可移除地固定在支撑表面上，例如桌子的边缘等。 夹具优选地构造成允许手部消毒站可拆卸地安装在水平设置的表面的边缘上，并且交替地到垂直设置的表面的边缘。 本发明提供了一种可拆卸地安装在支撑结构上的便携式手部消毒站，本发明提供一种手部消毒装置，其可以在现场快速而容易地部署，以提供能够分配大量手的临时手部消毒站 消毒剂