公开(公告)号：US20240069042A1

公开(公告)日：2024-02-29

申请号：US18387593

申请日：2023-11-07

申请人： NeuroQuest Ltd. ,  Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science

发明人： Xin Huang ,  Yihan Li ,  James Doecke ,  Michal Eisenbach-Schwartz ,  Baijun Gu

IPC分类号： G01N33/68 ,  G01N33/58

CPC分类号： G01N33/6896 ,  G01N33/582 ,  G01N2800/2821

摘要： Compositions and kits for diagnosing and prognosing Alzheimer's Disease (AD) in a human patient include a binding agent such as a monoclonal antibody for a biomarker conjugated to a detectable moiety such as a fluorophore, wherein the biomarker is chosen from CD11c, CD59, CD91, and CD163 and other phagocytosis-related molecules. Further compositions and kits employ panels of fluorophore-conjugated monoclonal antibodies for biomarkers including scavenger receptors. Methods for determining the relative expression of biomarkers, diagnosing AD, and determining the efficacy of AD therapeutic candidates such as phagocytosis-promoting agents and scavenger receptor agonists also appear.

公开(公告)号：US20230054073A1

公开(公告)日：2023-02-23

申请号：US17882671

申请日：2022-08-08

申请人： NEUROQUEST LTD.

发明人： Xin Huang ,  Yihan Li ,  Christopher Fowler ,  James Doecke ,  Colin L. Masters ,  Baijun Gu

IPC分类号： G01N33/58 ,  C07K16/28 ,  G01N33/68

摘要： Compositions and kits for diagnosing and prognosing Alzheimer's Disease (AD) in a human patient include a binding agent such as a monoclonal antibody for a biomarker conjugated to a detectable moiety such as a fluorophore, wherein the biomarker is chosen from CD163, CD91, CD59, MerTK and other phagocytosis-related molecules. Further compositions and kits employ panels of fluorophore-conjugated monoclonal antibodies for biomarkers including scavenger receptors. Methods for determining the relative expression of biomarkers, diagnosing AD, and determining the efficacy of AD therapeutic candidates such as phagocytosis-promoting agents and scavenger receptor agonists also appear.

公开(公告)号：US20150057176A1

公开(公告)日：2015-02-26

申请号：US14388369

申请日：2013-03-21

申请人： YEDA RESEARCH AND DEVELOPMENT CO., LTD. ,  NEUROQUEST LTD.

发明人： Michal Eisenbach-Schwartz ,  Ester Yoles

IPC分类号： G01N33/569 ,  G01N33/50

CPC分类号： G01N33/56972 ,  G01N33/5047 ,  G01N33/505 ,  G01N2800/2821 ,  G01N2800/50 ,  G01N2800/52

摘要： The present invention provides methods for early diagnosis of Alzheimer's disease and for determining the efficacy of a treatment for Alzheimer's disease in an Alzheimer's patient, i.e., monitoring Alzheimer's disease progression, utilizing cellular blood markers; as well as kits for carrying out these methods.

摘要翻译： 本发明提供早期诊断阿尔茨海默氏病和确定阿尔茨海默病患者阿尔茨海默病治疗功效的方法，即利用细胞血标记物监测阿尔茨海默病进展; 以及执行这些方法的工具包。