公开(公告)号：US20180125871A1

公开(公告)日：2018-05-10

申请号：US15570210

申请日：2016-04-28

申请人： David A. Sinclair ,  NewSouth Innovation Pty Limited

发明人： Lindsay Wu ,  David A. Sinclair

IPC分类号： A61K31/706 ,  A61P25/02

CPC分类号： A61K31/706 ,  A61K31/443 ,  A61K31/455 ,  A61K31/52 ,  A61K31/7076 ,  A61K38/45 ,  A61P25/02 ,  C12Y204/02012 ,  C12Y207/07001

摘要： Methods and compositions for preventing or treating peripheral neuropathy, cognitive deficits, inactivity, depression, chemotherapy and/or radiotherapy induced peripheral neuropathy and cognitive deficits, and improving cognitive performance, in a subject in need thereof are disclosed. The disclosed methods include the step of administering to the subject an effective amount of an agent that increases the level of NAD+ in the subject.

公开(公告)号：US20160279161A1

公开(公告)日：2016-09-29

申请号：US15036638

申请日：2014-11-14

申请人： NEWSOUTH INNOVATION PTY LIMITED

发明人： Lindsay Edward Wu ,  David Andrew Sinclair

IPC分类号： A61K31/7084 ,  A61K31/706 ,  A61K31/352

CPC分类号： A61K31/7084 ,  A61K8/498 ,  A61K31/352 ,  A61K31/706 ,  A61Q19/08

摘要： The present invention relates to a method of treating or preventing DNA damage in a cell or cellular senescence of a cell or induction of the senescence associated secretory phenotype (SASP) in a cell, or for treating or preventing the effects of aging, or for preventing or treating cellular senescence and/or induction of SASP associated with high caloric intake or obesity, or for reducing the side effects of chemotherapy, radiotherapy, corticoid treatment, anti-retroviral treatment, or PPARγ agonist treatment, comprising administering an effective amount of an NAD+ agonist.

摘要翻译： 本发明涉及一种治疗或预​​防细胞中DNA损伤或细胞衰老或诱导细胞衰老相关分泌表型（SASP）或用于治疗或预防老化作用或预防 或治疗与高热量摄取或肥胖相关的SASP的细胞衰老和/或诱导，或用于减少化学疗法，放射治疗，皮质激素治疗，抗逆转录病毒治疗或PPARγ激动剂治疗的副作用，包括施用有效量的NAD + 激动剂。