NUCLEIC ACID-MEDIATED SHAPE CONTROL OF NANOPARTICLES FOR BIOMEDICAL APPLICATIONS
    1.
    发明申请
    NUCLEIC ACID-MEDIATED SHAPE CONTROL OF NANOPARTICLES FOR BIOMEDICAL APPLICATIONS 审中-公开
    用于生物医学应用的纳米颗粒的核酸介导形状控制

    公开(公告)号:US20120107242A1

    公开(公告)日:2012-05-03

    申请号:US13249070

    申请日:2011-09-29

    摘要: Embodiments of a method for nucleic acid-mediated control of a nanoparticle shape are disclosed. In some embodiments, one or more nucleic acid oligomers are adsorbed to a metal nanoseed, and additional metal is deposited onto the nanoseed to produce a shaped nanoparticle. In certain embodiments, the nanoseed is gold and the oligomers are 5-100 nucleotides in length. The nanoparticle shape is determined at least in part by the nucleic acid sequence of the oligomer(s). Shaped nanoparticles produced by embodiments of the method include nanoflowers, nanospheres, nanostars, and nanoplates. Embodiments for using the shaped nanoparticles also are disclosed.

    摘要翻译: 公开了核酸介导的纳米颗粒形状的控制方法的实施方案。 在一些实施方案中,一种或多种核酸低聚物被吸附到金属纳米籽粒上,并且另外的金属沉积到纳米籽粒上以产生成形的纳米颗粒。 在某些实施方案中,纳米籽粒是金,寡聚体长度为5-100个核苷酸。 至少部分地由寡聚体的核酸序列确定纳米颗粒形状。 通过该方法的实施方案制备的成形纳米微粒包括纳米花粉,纳米球,纳米棒和纳米片。 公开了使用成形纳米颗粒的实施方案。