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公开(公告)号：US20130197094A1
公开(公告)日：2013-08-01
申请号：US13363469
申请日：2012-02-01
IPC分类号： A61K31/165 , A61P25/00
CPC分类号： A61K31/165 , A61K9/0024 , A61K9/70 , A61K31/357
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of a TRPV1 compound (e.g., capsaicinoid compound) at or near a target site, one can relieve pain caused by diverse sources, including but not limited to, postoperative pain, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或附近施用有效量的TRPV1化合物（例如辣椒素类化合物），可以减轻由多种来源引起的疼痛，包括但不限于术后疼痛，脊髓椎间盘突出症（即坐骨神经痛） 脊柱脱位，狭窄，椎间盘背痛和关节疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。
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公开(公告)号：US09211274B2
公开(公告)日：2015-12-15
申请号：US13363469
申请日：2012-02-01
IPC分类号： A61F2/00 , A61K31/165 , A61K9/00 , A61K31/357 , A61K9/70
CPC分类号： A61K31/165 , A61K9/0024 , A61K9/70 , A61K31/357
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of a TRPV1 compound (e.g., capsaicinoid compound) at or near a target site, one can relieve pain caused by diverse sources, including but not limited to, postoperative pain, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或附近施用有效量的TRPV1化合物（例如辣椒素类化合物），可以减轻由多种来源引起的疼痛，包括但不限于术后疼痛，脊髓椎间盘突出症（即坐骨神经痛） 脊柱脱位，狭窄，椎间盘背痛和关节疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。
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公开(公告)号：US09511018B2
公开(公告)日：2016-12-06
申请号：US13439971
申请日：2012-04-05
IPC分类号： A61F13/00 , A61K31/415 , A61K9/00 , A61K31/4168 , A61K47/34
CPC分类号： A61K9/0024 , A61K31/4168 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine in a matrix at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate matrix formulations are provided within biodegradable polymers, this pain relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或其附近的基质中施用有效量的可乐定，可以减轻由多种来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节 疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物内提供适当的基质制剂时，可以持续至少三天的疼痛缓解。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。
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公开(公告)号：US20130266631A1
公开(公告)日：2013-10-10
申请号：US13439971
申请日：2012-04-05
IPC分类号： A61K9/00 , A61P29/00 , A61K31/4168
CPC分类号： A61K9/0024 , A61K31/4168 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine in a matrix at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate matrix formulations are provided within biodegradable polymers, this pain relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.
摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位或其附近的基质中施用有效量的可乐定，可以减轻由多种来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节 疼痛，以及手术附带的疼痛。 当在可生物降解的聚合物内提供适当的基质制剂时，可以持续至少三天的疼痛缓解。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。
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