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公开(公告)号：US20130045955A1
公开(公告)日：2013-02-21
申请号：US13587575
申请日：2012-08-16
IPC分类号： A61K31/505 , A61K31/56 , C07D403/12 , A61K31/506 , A61K31/551 , C07D239/49 , C07D401/12 , C07D413/12 , A61K31/5377 , C07D417/12 , A61K31/541 , A61P11/00 , A61P17/00 , A61P11/06 , A61P35/00 , A61P11/02 , A61P31/18 , A61P31/20 , A61P31/14 , A61P31/04 , C07D239/48
CPC分类号： C07D239/48 , C07D239/49 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D417/12
摘要： The present invention provides compounds of formula (I) herein R1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供了式（I）化合物，其中R1，R2，R3和R4如说明书中所定义，及其药学上可接受的盐，以及其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US20090209524A1
公开(公告)日：2009-08-20
申请号：US12274915
申请日：2008-11-20
IPC分类号： A61K31/551 , A61K31/535 , A61K31/497 , C07D413/12 , C07D403/12 , C07D401/12
CPC分类号： C07D239/48 , C07D239/49 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D417/12
摘要： The present invention provides compounds of formula (1) wherein R1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（1）的化合物，其中R 1，R 2，R 3和R 4如说明书中所定义，及其药学上可接受的盐，以及其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US08765939B2
公开(公告)日：2014-07-01
申请号：US13587575
申请日：2012-08-16
IPC分类号： C07D345/00 , C07D517/00
CPC分类号： C07D239/48 , C07D239/49 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D417/12
摘要： The present invention provides compounds of formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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公开(公告)号：US08268990B2
公开(公告)日：2012-09-18
申请号：US12274915
申请日：2008-11-20
IPC分类号： C07D201/16
CPC分类号： C07D239/48 , C07D239/49 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D417/12
摘要： The present invention provides compounds of formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物，其中R 1，R 2，R 3和R 4如说明书中所定义，及其药学上可接受的盐，以及其制备方法，含有它们的药物组合物及其在治疗中的用途。
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