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公开(公告)号：US08765939B2
公开(公告)日：2014-07-01
申请号：US13587575
申请日：2012-08-16
IPC分类号： C07D345/00 , C07D517/00
CPC分类号： C07D239/48 , C07D239/49 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D417/12
摘要： The present invention provides compounds of formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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公开(公告)号：US20130045955A1
公开(公告)日：2013-02-21
申请号：US13587575
申请日：2012-08-16
IPC分类号： A61K31/505 , A61K31/56 , C07D403/12 , A61K31/506 , A61K31/551 , C07D239/49 , C07D401/12 , C07D413/12 , A61K31/5377 , C07D417/12 , A61K31/541 , A61P11/00 , A61P17/00 , A61P11/06 , A61P35/00 , A61P11/02 , A61P31/18 , A61P31/20 , A61P31/14 , A61P31/04 , C07D239/48
CPC分类号： C07D239/48 , C07D239/49 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D417/12
摘要： The present invention provides compounds of formula (I) herein R1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供了式（I）化合物，其中R1，R2，R3和R4如说明书中所定义，及其药学上可接受的盐，以及其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US20080300244A1
公开(公告)日：2008-12-04
申请号：US11955984
申请日：2007-12-13
IPC分类号： A61K31/5377 , C07D473/34 , A61P35/00 , A61P11/00
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula wherein R1, Y1, X1, Z1, X2, Y2, A, n and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供下式的化合物，其中R1，Y1，X1，Z1，X2，Y2，A，n和R2如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US08067411B2
公开(公告)日：2011-11-29
申请号：US11955984
申请日：2007-12-13
IPC分类号： C07D473/18 , A61K31/522 , A61P11/06 , A61P37/08
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula wherein R1, Y1, X1, Z1, X2, Y2, A, n and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供下式的化合物，其中R1，Y1，X1，Z1，X2，Y2，A，n和R2如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US08268990B2
公开(公告)日：2012-09-18
申请号：US12274915
申请日：2008-11-20
IPC分类号： C07D201/16
CPC分类号： C07D239/48 , C07D239/49 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D417/12
摘要： The present invention provides compounds of formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物，其中R 1，R 2，R 3和R 4如说明书中所定义，及其药学上可接受的盐，以及其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US20090143400A1
公开(公告)日：2009-06-04
申请号：US12066952
申请日：2006-09-12
申请人： Thomas McInally , Stephen Thom , Hiroki Wada
发明人： Thomas McInally , Stephen Thom , Hiroki Wada
IPC分类号： A61K31/496 , C07D473/18 , A61K31/522 , A61P31/12 , A61P35/00 , A61P37/08 , A61P11/00
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula wherein n, Y, Z, R, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供下式的化合物，其中n，Y，Z，R，R 1，R 2和R 3如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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公开(公告)号：US20060264435A1
公开(公告)日：2006-11-23
申请号：US10551783
申请日：2004-04-06
申请人： Roger Bonnert , Stephen Brough , Andrew Davies , Timothy Luker , Thomas McInally , Ian Millichip , Garry Pairaudeau , Anil Patel , Rukshana Rasul , Stephen Thom
发明人： Roger Bonnert , Stephen Brough , Andrew Davies , Timothy Luker , Thomas McInally , Ian Millichip , Garry Pairaudeau , Anil Patel , Rukshana Rasul , Stephen Thom
IPC分类号： A61K31/5377 , A61K31/4706 , A61K31/44 , A61K31/513 , A61K31/506
CPC分类号： C07C59/68 , C07C59/70 , C07C65/24 , C07C69/94 , C07C205/35 , C07C205/37 , C07C217/80 , C07C235/42 , C07C255/55 , C07C271/28 , C07C275/32 , C07C311/29 , C07C317/22 , C07C323/18 , C07C2601/02 , C07D205/04 , C07D207/02 , C07D213/61 , C07D213/72 , C07D215/12 , C07D233/52 , C07D239/26 , C07D239/34 , C07D239/42 , C07D277/52 , C07D285/10 , C07D295/192 , C07D295/26 , C07D307/80 , C07D317/54 , C07D333/56 , C07D403/04 , C07D417/04
摘要： The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
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公开(公告)号：US20110166117A1
公开(公告)日：2011-07-07
申请号：US12982435
申请日：2010-12-30
申请人： Roger Bonnert , Stephen Brough , Andrew Davies , Timothy Luker , Thomas McInally , Ian Millichip , Garry Pairaudeau , Anil Patel , Rukhsana Rasul , Stephen Thom
发明人： Roger Bonnert , Stephen Brough , Andrew Davies , Timothy Luker , Thomas McInally , Ian Millichip , Garry Pairaudeau , Anil Patel , Rukhsana Rasul , Stephen Thom
IPC分类号： A61K31/506 , C07C59/70 , A61K31/192 , A61P11/06 , A61P11/02 , C07D215/06 , A61K31/47 , C07C255/54 , A61K31/277 , C07C205/37 , C07D239/26 , A61K31/505 , C07D213/71 , A61K31/4418 , C07D239/42 , C07D413/04 , A61K31/5377 , A61K31/397
CPC分类号： C07C59/68 , C07C59/70 , C07C65/24 , C07C69/94 , C07C205/35 , C07C205/37 , C07C217/80 , C07C235/42 , C07C255/55 , C07C271/28 , C07C275/32 , C07C311/29 , C07C317/22 , C07C323/18 , C07C2601/02 , C07D205/04 , C07D207/02 , C07D213/61 , C07D213/72 , C07D215/12 , C07D233/52 , C07D239/26 , C07D239/34 , C07D239/42 , C07D277/52 , C07D285/10 , C07D295/192 , C07D295/26 , C07D307/80 , C07D317/54 , C07D333/56 , C07D403/04 , C07D417/04
摘要： The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
摘要翻译： 本发明涉及取代的苯氧基乙酸（I）作为治疗呼吸系统疾病的有用的药物化合物，含有它们的药物组合物及其制备方法。
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9.发明申请9-SUBSTITUTED-8-OXO-ADENINE COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR7) MODULATORS 失效作为类似感受器（TLR7）调节剂的9-替代的8-氧 - 腺嘌呤化合物公开(公告)号：US20100087443A1
公开(公告)日：2010-04-08
申请号：US12532084
申请日：2008-03-19
IPC分类号： A61K31/522 , C07D473/18 , A61K31/496 , A61P11/00 , A61P35/00 , A61P31/00
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula where n, R1, R2, A, X1, Y1, Z1, X2 and Y2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供下式的化合物，其中n，R1，R2，A，X1，Y1，Z1，X2和Y2如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。
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10.发明申请PURINE DERIVATIVES FOR THE TREATMENT OF VIRAL OR ALLERGIC DISEASES AND CANCERS 审中-公开用于治疗病毒或过敏性疾病和癌症的嘌呤衍生物公开(公告)号：US20090082332A1
公开(公告)日：2009-03-26
申请号：US12067536
申请日：2006-09-20
申请人： Philip Abbot , Roger Victor Bonnert , Stephen Brough , Kamaldeep Chohan , Thomas McInally , Stephen Thom , Yoshiaki Isobe , Kei Nakamura , Shingo Tojo
发明人： Philip Abbot , Roger Victor Bonnert , Stephen Brough , Kamaldeep Chohan , Thomas McInally , Stephen Thom , Yoshiaki Isobe , Kei Nakamura , Shingo Tojo
IPC分类号： A61K31/397 , C07D473/02 , A61P31/12 , A61P35/00 , A61P37/08 , A61K31/522
CPC分类号： C07D473/34
摘要： The present invention provides compounds of formula (I) wherein R1, Y1, X1, Z1, X2, Y2, A, Y3, n, R and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译： 本发明提供式（I）化合物，其中R1，Y1，X1，Z1，X2，Y2，A，Y3，n，R和R2如说明书中所定义，其制备方法，含有它们的药物组合物及其制备方法 用于治疗。
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