公开(公告)号：US5985913A

公开(公告)日：1999-11-16

申请号：US69693

申请日：1998-04-29

申请人： Jonathan Gareth Williams ,  David R. Houck ,  David Edward Smith ,  Daniel Lee Rathbone ,  David Charles Billington ,  Bernard T. Golding ,  Eric W. Collington ,  John Kitchin ,  Nicholas Rich

发明人： Jonathan Gareth Williams ,  David R. Houck ,  David Edward Smith ,  Daniel Lee Rathbone ,  David Charles Billington ,  Bernard T. Golding ,  Eric W. Collington ,  John Kitchin ,  Nicholas Rich

IPC分类号： A61K31/352 ,  C07D311/94 ,  A61K31/35 ,  A61K31/365 ,  C07D311/78

CPC分类号： C07D311/94 ,  A61K31/352

摘要： The present invention provides a compound in substantially pure form having the structure: ##STR1## wherein each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 may independently be hydrogen, halogen, nitro, CF.sub.3, hydroxy, C.sub.1-5 alkyl, aryl or OR.sub.9, wherein R.sub.9 is C.sub.1-5 alkyl, wherein R.sub.10 is COC.sub.1-5 alkyl; or wherein any two consecutive R groups may be members of a C.sub.5 -C.sub.6 membered ring, and wherein the intracyclic-dashed line represents a covalent bond which may be present or absent, with the proviso that when R.sub.10 is present, the exocyclic-covalent bond is absent, and when R.sub.10 is absent, the exocyclic-covalent bond is present, and with the proviso that when R.sub.10 is absent, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 cannot all be hydrogen and when R.sub.10 is absent, R.sub.5, R.sub.6, R.sub.7, and R.sub.8 cannot all be hydrogen when either R.sub.1, R.sub.2, R.sub.3, or R.sub.4 is hydroxy, or R2 is carboethoxy. The present invention further provides a composition comprising the compound described above in an amount effective to modulate cellular expression of a mammalian gene encoding erythropoietin and a carrier.

摘要翻译： 本发明提供具有以下结构的基本上纯的形式的化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8各自独立地为氢，卤素，硝基，CF 3，羟基，C 1-5烷基 ，芳基或OR9，其中R9为C1-5烷基，其中R10为COC1-5烷基; 或其中任何两个连续的R基团可以是C 5 -C 6的环的成员，并且其中所述环内虚线表示可以存在或不存在的共价键，条件是当R 10存在时，所述环外共价键为 当不存在R 10时，存在环外共价键，条件是当R 10不存在时，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8不能全部为氢，当R 10为 当R 1，R 2，R 3或R 4为羟基或R 2为乙氧基乙氧基时，R 5，R 6，R 7和R 8不能全部为氢。 本发明还提供一种包含上述化合物的组合物，其量可有效调节编码促红细胞生成素和载体的哺乳动物基因的细胞表达。

公开(公告)号：US20240123267A1

公开(公告)日：2024-04-18

申请号：US17966843

申请日：2022-10-16

申请人： Jason Nicholas Rich

发明人： Jason Nicholas Rich

IPC分类号： A62B23/02 ,  A61L9/014 ,  A62B18/10 ,  B01D46/00 ,  B01D46/52

CPC分类号： A62B23/025 ,  A61L9/014 ,  A62B18/10 ,  B01D46/0032 ,  B01D46/521 ,  A61L2209/14

摘要： A unique filtering face-piece respirator or mask that is constructed of filtration media capable of sub-micron particle absorption or filtration. Utilizing existing and broadly available low cost media, the mask is patterned from a single sheet of material. It is constructed in a manner that creates an adequate seal as it fits snugly to the user's face, creates structure to ensure a low volume air gap, and deploys unique vertical pleats to increase surface area in order to decrease pressure drop across the mask. Specifically, the design enables the user to inhale and exhale with a pressure drop below 0.4 inches of water at elevated breathing rates of up to 110 liters per hour. Valve design and positioning enable more than 90% of used air to be exited the mask. Meeting these criteria, the mask is intended to be a low cost solution that provides protection from virus, air pollution, or other pathogens with little restriction, allowing subjectively ‘comfortable’ usage during sports and other highly aerobic activities.

公开(公告)号：US20070027736A1

公开(公告)日：2007-02-01

申请号：US10558968

申请日：2004-06-01

申请人： Damon Reynolds ,  Liz Soutar ,  Simon James ,  Nicholas Rich ,  Kate Rosser ,  Alejandra Oliver ,  Dominic Keen ,  Nicholas Leonard ,  Dan Hurell ,  John Fussell ,  Adam French ,  Paul Oram ,  Steve Osborn ,  Andrew MacLaren

发明人： Damon Reynolds ,  Liz Soutar ,  Simon James ,  Nicholas Rich ,  Kate Rosser ,  Alejandra Oliver ,  Dominic Keen ,  Nicholas Leonard ,  Dan Hurell ,  John Fussell ,  Adam French ,  Paul Oram ,  Steve Osborn ,  Andrew MacLaren

IPC分类号： G06F9/46

CPC分类号： G06Q40/02 ,  G06Q10/0637 ,  G06Q40/00

摘要： There is disclosed a computer apparatus incorporating a model component for calculating time series and a user interface component for controlling the model and displaying the time series. The user interface allows events to be defined which are used by the model, by positioning event markers relative to an event schedule graphic. The apparatus may be used as a financial planning tool, in which case the model is a financial model and the events are financial events. Such a planning tool may further incorporate a component to provide planning suggestions based on the model and defined events.

摘要翻译： 公开了一种结合用于计算时间序列的模型部件和用于控制模型并显示时间序列的用户界面部件的计算机装置。 通过将事件标记相对于事件计划图形定位，用户界面允许定义模型使用的事件。 该设备可以用作财务计划工具，在这种情况下，该模型是财务模型，事件是金融事件。 这样的规划工具可以进一步包含一个组件以基于模型和定义的事件来提供规划建议。