摘要:
The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.
摘要:
The present invention provides, with reference to FIG. 2, an amphibian operable in land and marine modes, the amphibian comprising a hull, at least one discontinuity (wheel bay) provided in the hull, and at least one retractable wheel or track assembly at least partially located in the at least one discontinuity (wheel bay). The hull is a planning hull, and the at least one discontinuity (wheel bay) is provided in the front half of the hull of the amphibian. The amphibian further comprises at least one conduit which opens, or is provided with an entry which opens, into or at the at least one discontinuity (wheel bay) and is configured for channeling, in use, fluid away from the at least one discontinuity (wheel bay).
摘要:
A wireless personal-area network (PAN) communication system includes a first device configured to simultaneously transmit a digitized stereo audio signal to and receive a digitized voice signal from a second device over the wireless PAN. The system also includes the second device, which is configured to simultaneously receive the digitized stereo audio signal from the first device and transmit the digitized voice signal to the first device over the PAN. The wireless PAN can be a Bluetooth® network. Low-latency audio codecs may be included in the first and second devices to reduce the latency of the voice and stereo audio signals transferred between the devices.
摘要:
A primer-less coating composition for facestock comprises: a binder being a water-dispersible polymer; an ethylenically unsaturated compound which is aqueous-dispersible and miscible with or bonded to said water-dispersible polymer, wherein said ethylenically unsaturated compound is able to form a covalent bond with an ink; and a crosslinker, wherein said crosslinker is suitable for binding the coating to the facestock. The coating composition may be applied to a substrate to form a printable film. A printed film in accordance with the invention may be used in a label, for example for use on a container such as a bottle.
摘要:
A motorized foldable scooter has a frame, at least a front and rear wheel connected to the frame, a seat supported by the frame, a steering arrangement for the front wheel, and an electric motor, driving the rear wheel through a transmission. The frame has at least front and rear frame parts movably connected through a substantially vertical rotary axis to move the frame parts between an extended position of use and a collapsed resting position. The steering arrangement and the seat, and/or the front and rear frame parts are shaped such with respect to each other and the rotary axis that they at least partly nest in lateral direction of the scooter when the frame parts are in the collapsed resting position.
摘要:
The invention relates to amino-heteroaryl derivatives having the general Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of these derivatives for the treatment of pain, such as neuropathic pain or inflammatory pain.
摘要:
Techniques are provided to automatically configure packet based network services over Dense Wavelength Division Multiplex (DWDM) network communication links. An optical wavelength is detected at an optical interface of a network device configured to send traffic between a packet switched network and an optical network. A message is sent to an optical control plane comprising information configured to request optical configuration information for the optical wavelength. A response to the message is received comprising the optical configuration information and the wavelength is activated at the optical interface using the optical configuration information. A frame is received over the wavelength that is formatted according to an optical protocol. Packet switched network information is extracting from an overhead portion of the frame that is configured to identify network parameters for configuring a packet switched network link and the associated routing. The packet switched network link is configured using the network parameters.
摘要:
The present invention relates to compounds of formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要:
The external surface of a tubular body such as well casing is coated with a substance that, upon exposure to cement, is unstable and degrades. After installation in a subterranean well and subsequent cementation, the coating degrades and forms a gap between the external surface of the tubular body and the cement sheath. Forming the gap is useful for obtaining optimal stimulation during the hydraulic fracturing of unconventional shale-gas formations.
摘要:
A fire and explosion suppression system comprises a source (5) of high pressure water which is fed to a misting nozzle (13) at one input of a mixing unit (6), and a source (14) of high pressure inert gas, such as nitrogen, which is fed along a pipe (20) to another input of the mixing unit (6). Inside the mixing unit (6), water mist, in the form of an atomized mist of very small droplet size is mixed with the pressurized gas and exits the mixing unit (6) at high pressure and high velocity along a pipe (22) and is thence discharged through spreaders (26, 28). The source (5) of the water is pressurized by a feed (30) from the source of pressurized inert gas. The mass flow rate of the water will therefore reduce as the pressure of the gas decays. This tends to maintain the ratio of the mass flow rate of the water to the mass flow rate of the gas constant. This is found to produce and maintain an advantageous distribution of droplet size in the discharged unit. A control unit (10) adjusts a metering valve (7) in dependence on the mass flow rate or the pressure of the gas in order to adjust the ratio as necessary to maintain its value constant.