公开(公告)号：US20090048269A1

公开(公告)日：2009-02-19

申请号：US12190008

申请日：2008-08-12

申请人： Maurice Raymond Finlay ,  Frederick Woolf Goldberg ,  Craig Anthony Roberts ,  Nicola Jane Roberts ,  David Alan Rudge

发明人： Maurice Raymond Finlay ,  Frederick Woolf Goldberg ,  Craig Anthony Roberts ,  Nicola Jane Roberts ,  David Alan Rudge

IPC分类号： A61K31/497 ,  C07D401/12 ,  C07D401/14 ,  A61K31/444

CPC分类号： C07D213/74 ,  C07D401/14 ,  C07D409/14 ,  C07D417/14

摘要： The invention relates to chemical compounds of the formula (I), or pharmaceutically acceptable salts thereof, which possess ALK5 (TGFβR1) inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an anti-cancer effect in a warm-blooded animal such as man.

摘要翻译： 本发明涉及具有ALK5（TGFbetaR1）抑制活性的式（I）化合物或其药学上可接受的盐，因此可用于其抗癌活性，因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制造用于在温血动物如人中产生抗癌作用的药物中的用途。