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    N-{'4-substituted piperazine-1-sulfonylmethyl!alkyl}-n-hydroxyfomamide compounds as metalloproteinase inhibitors
    5.
    发明申请
    N-{'4-substituted piperazine-1-sulfonylmethyl!alkyl}-n-hydroxyfomamide compounds as metalloproteinase inhibitors 失效
    N - {'4-取代哌嗪-1-磺酰基甲基}烷基} -N-羟基甲酰胺化合物作为金属蛋白酶抑制剂

    公开(公告)号：US20070197542A1

    公开(公告)日：2007-08-23

    申请号：US10561747

    申请日：2004-06-23

    申请人： Maurice Raymond Finlay ,  David Waterson

    发明人： Maurice Raymond Finlay ,  David Waterson

    IPC分类号： A61K31/506 ,  A61K31/496 ,  A61K31/495 ,  C07D403/04

    CPC分类号： C07D239/47 ,  C07D295/26 ,  C07D309/04 ,  C07D401/12 ,  C07D405/12

    摘要： The invention provides compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein ring B represents a monocyclic aryl ring having six ring atoms or a monocyclic heteroaryl ring having up to six ring atoms and containing one or more ring heteroatoms wherein each said heteroatom is nitrogen; R2 represents a group selected from C1-6 alkyl or aryl, which said group is substituted by one or more fluorine groups; n is 1, 2 or 3; and R1 represents an optionally substituted group selected from C1-6 alkyl, C5-7 cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-6 alkyl-aryl, C1-6 alkyl-heteroaryl, C1-6 alkyl-cycloalkyl or C1-6 alkyl-heterocycloalkyl. Processes for their preparation; pharmaceutical compositions containing them; and their use in the treatment of a disease condition mediated by one or more metalloproteinase enzymes.

    摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐，前药或溶剂化物，其中环B表示具有六个环原子的单环芳基环或具有至多六个环原子并含有一个或多个环的单环杂芳基环 其中每个所述杂原子是氮的杂原子; R2表示选自C1-6烷基或芳基的基团，所述基团被一个或多个氟基团取代; n为1,2或3; 并且R 1表示任选取代的基团，其选自C 1-6烷基，C 5-7环烷​​基，杂环烷基，芳基，杂芳基，C 1-6烷基 - 芳基，C 1-6烷基 - 杂芳基，C 1-6烷基 - 环烷基或C 1-6烷基 - 杂环烷基。 其准备过程; 含有它们的药物组合物; 以及它们用于治疗由一种或多种金属蛋白酶介导的疾病状况的用途。