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1.发明申请Antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen and uses thereof 有权抗T细胞免疫球蛋白结构域和粘蛋白结构域1（TIM-1）抗原的抗体及其用途公开(公告)号：US20050084449A1
公开(公告)日：2005-04-21
申请号：US10805177
申请日：2004-03-19
申请人： Gregory Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
发明人： Gregory Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
CPC分类号： C07K16/2803 , A61K51/1039 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/50 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N2333/70503
摘要： The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译： 本文描述的发明涉及针对抗原TIM-1的抗体和这种抗体的用途。 特别地，提供针对抗原TIM-1的完全人单克隆抗体。 分离的多核苷酸序列编码和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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2.发明授权Antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen and uses thereof 有权抗T细胞免疫球蛋白结构域和粘蛋白结构域1（TIM-1）抗原的抗体及其用途公开(公告)号：US09580503B2
公开(公告)日：2017-02-28
申请号：US13305898
申请日：2011-11-29
申请人： Gregory M. Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Fai Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
发明人： Gregory M. Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Fai Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/2803 , A61K51/1039 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/50 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N2333/70503
摘要： The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译： 本文描述的发明涉及针对抗原TIM-1的抗体和这种抗体的用途。 特别地，提供针对抗原TIM-1的完全人单克隆抗体。 分离的多核苷酸序列编码和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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3.发明申请ANTIBODIES AGAINST T CELL IMMUNOGLOBULIN DOMAIN AND MUCIN DOMAIN 1 (TIM-1) ANTIGEN AND USES THEREOF 有权针对T细胞免疫球蛋白域和MUCIN域1（TIM-1）抗原的抗体及其用途公开(公告)号：US20120251555A1
公开(公告)日：2012-10-04
申请号：US13305898
申请日：2011-11-29
申请人： Gregory M. Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Fai Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
发明人： Gregory M. Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Fai Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
IPC分类号： C07K16/28 , C12N5/10 , A61P35/00 , A61K39/395 , G01N33/574 , G01N21/64 , C12N5/16 , C12N5/09
CPC分类号： C07K16/2803 , A61K51/1039 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/50 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N2333/70503
摘要： The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译： 本文描述的发明涉及针对抗原TIM-1的抗体和这种抗体的用途。 特别地，提供针对抗原TIM-1的完全人单克隆抗体。 分离的多核苷酸序列编码和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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4.发明授权Antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen and uses thereof 有权抗T细胞免疫球蛋白结构域和粘蛋白结构域1（TIM-1）抗原的抗体及其用途公开(公告)号：US08067544B2
公开(公告)日：2011-11-29
申请号：US10805177
申请日：2004-03-19
申请人： Gregory M. Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Fai Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
发明人： Gregory M. Landes , Francine Chen , Binyam Bezabeh , Ian Foltz , Kam Fai Tse , Michael Jeffers , Mehdi Mesri , Gary Starling , Peter Mezes , Nikolia Khramtsov
IPC分类号： C07K16/00
CPC分类号： C07K16/2803 , A61K51/1039 , A61K2039/505 , C07K16/28 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/50 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N2333/70503
摘要： The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
摘要翻译： 本文描述的发明涉及针对抗原TIM-1的抗体和这种抗体的用途。 特别地，提供针对抗原TIM-1的完全人单克隆抗体。 分离的多核苷酸序列编码和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区（FR）和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是FR1至FR4 或CDR1至CDR3。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
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