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    Use of substituted 2,3-dihydroimidazo[1,2-C]quinazolines
    2.
    发明授权
    Use of substituted 2,3-dihydroimidazo[1,2-C]quinazolines 有权

    公开(公告)号：US10202385B2

    公开(公告)日：2019-02-12

    申请号：US14009751

    申请日：2012-03-29

    申请人： Ningshu Liu ,  Claudia Schneider

    发明人： Ningshu Liu ,  Claudia Schneider

    IPC分类号： A61K31/436 ,  A61K31/5377 ,  C07D487/04 ,  A61K31/517 ,  A61K45/06 ,  A61K31/635 ,  C12Q1/6886 ,  G01N33/574

    摘要： The present invention relates to: —use of a 2,3-dihydroimidazo[1,2-c]quinazoline compound, or of a pharmaceutical composition containing same, as a sole active agent, or of a combination of a) said compound or a pharmaceutical composition containing said compound and b) one or more further active agents, for the preparation of a medicament for the treatment or prophylaxis of cancer; —combinations of a) said compound and b) one or more further active agents; —a pharmaceutical composition comprising said compound as a sole active agent for the treatment of breast cancer; —a pharmaceutical composition comprising a combination of a) said compound and b) one or more further active agents; —use of biomarkers involved in the modification of Bel expression, HER family expression and/or activation, PIK3CA signaling and/or loss of PTEN for predicting the sensitivity and/or resistance of a cancer patient to said compound and providing a rationale-based synergistic combination as defined herein to increase sensitivity and/or to overcome resistance; and —a method of determining the level of a component of one or more of Bcl expression, HER family expression and/or activation, PIK3CA signaling and/or loss of PTEN.

    ALKOXY-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINES
    4.
    发明申请
    ALKOXY-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINES 有权
    烷基取代的2,3-二氢吲哚并[1,2-C]喹唑啉

    公开(公告)号：US20130330327A1

    公开(公告)日：2013-12-12

    申请号：US13885038

    申请日：2011-11-08

    申请人： William Johnston Scott ,  Manfred Möwes ,  Ningshu Liu ,  Ursula Mönning ,  Ulf Bomer

    发明人： William Johnston Scott ,  Manfred Möwes ,  Ningshu Liu ,  Ursula Mönning ,  Ulf Bomer

    IPC分类号： A61K31/541 ,  A61K39/395 ,  A61K31/519 ,  C07D487/04 ,  A61K31/5377

    CPC分类号： A61K31/541 ,  A61K31/519 ,  A61K31/5377 ,  A61K39/39558 ,  C07D487/04

    摘要： The present invention relates to alkoxy-substituted 2,3-dihydroimidazo[1,2-c]quinazoline compounds of general formula (I) in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

    摘要翻译： 本发明涉及通式（I）的烷氧基​​取代的2,3-二氢咪唑并[1,2-c]喹唑啉化合物，其中R 1，R 2和R 3如权利要求中所定义，与制备所述化合物的方法相关， 用于制备所述化合物的中间体，包含所述化合物的药物组合物和组合，以及所述化合物用于制备用于治疗或预防疾病，特别是高增殖和/或血管生成障碍的药物组合物的用途， 作为唯一的药剂或与其它活性成分组合。

    USE OF SUBSTITUTED 2, 3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINES FOR THE TREATMENT OF MYELOMA
    8.
    发明申请
    USE OF SUBSTITUTED 2, 3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINES FOR THE TREATMENT OF MYELOMA 审中-公开
    用于治疗MYELOMA的2,3-DIHYDROIMIDAZO [1,2-C]喹唑啉的应用

    公开(公告)号：US20110251191A1

    公开(公告)日：2011-10-13

    申请号：US13120548

    申请日：2009-09-11

    申请人： Ningshu Liu

    发明人： Ningshu Liu

    IPC分类号： A61K31/5377 ,  A61P35/00

    CPC分类号： A61K31/5377 ,  A61K31/519

    摘要： The present invention relates to the use of 2,3-dihydroimidazo[1,2-c]quinazoline compounds, and of pharmaceutical compositions containing such compounds, for the treatment or prophylaxis of multiple myeloma, as a sole agent or in combination with other one or more other active ingredients.

    摘要翻译： 本发明涉及2,3-二氢咪唑并[1,2-c]喹唑啉化合物和含有这些化合物的药物组合物的用途，用于治疗或预防多发性骨髓瘤作为唯一的药剂或与其它药物组合 或更多其他活性成分。