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公开(公告)号:US08957064B2
公开(公告)日:2015-02-17
申请号:US13201277
申请日:2010-02-02
申请人: Matthias Vennemann , Thomas Bär , Thomas Maier , Swen Hölder , Gerrit Beneke , Florian Dehmel , Armin Zülch , Andreas Strub , Stuart Ince , Hartmut Rehwinkel , Ningshu Liu , Ulf Bömer , Barbara Beckers
发明人: Matthias Vennemann , Thomas Bär , Thomas Maier , Swen Hölder , Gerrit Beneke , Florian Dehmel , Armin Zülch , Andreas Strub , Thomas Beckers , Stuart Ince , Hartmut Rehwinkel , Ningshu Liu , Ulf Bömer
IPC分类号: A61K31/495 , A61K31/519 , A61K31/505 , C07D401/12 , C07D487/04 , A61K45/06 , C07D471/04
CPC分类号: A61K31/519 , A61K31/495 , A61K31/505 , A61K45/06 , C07D401/12 , C07D471/04 , C07D487/04
摘要: Compounds of formula (I) or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6, R7, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
摘要翻译: 式(I)化合物或所述化合物的N-氧化物,盐,互变异构体或立体异构体,或所述N-氧化物,互变异构体或立体异构体的盐,其中环B和与其稠合的嘧啶,R4 R5,R6,R7,m和n具有在描述和权利要求中给出的含义,它们是Pi3K / Akt途径的有效抑制剂,其生产方法及其作为药物的用途。
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公开(公告)号:US09206185B2
公开(公告)日:2015-12-08
申请号:US14007427
申请日:2012-04-05
申请人: Lars Bärfacker , William Scott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Hans Briem , Ulf Bömer
发明人: Lars Bärfacker , William Scott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Hans Briem , Ulf Bömer
IPC分类号: C07D487/04 , A61K31/5025 , A61K45/06
CPC分类号: C07D487/04 , A61K31/5025 , A61K45/06
摘要: The application relates to imidazopyridazines of formula (I) which are useful as Akt inhibitors suitable for the treatment of cancer, and processes for their production and the use thereof.
摘要翻译: 本申请涉及可用作适于治疗癌症的Akt抑制剂及其制备方法及其用途的式(I)咪唑并哒嗪。
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公开(公告)号:US20130184273A1
公开(公告)日:2013-07-18
申请号:US13808461
申请日:2011-07-11
申请人: Stuart Ince , Hartmut Rehwinkel , Andrea Hägebarth , Oliver Politz , Roland Neuhaus , Ulf Bömer
发明人: Stuart Ince , Hartmut Rehwinkel , Andrea Hägebarth , Oliver Politz , Roland Neuhaus , Ulf Bömer
IPC分类号: A61K31/5377 , A61K31/519 , A61K45/06 , C07D487/04
CPC分类号: A61K31/5377 , A61K31/519 , A61K45/06 , C07D487/04
摘要: Compounds of formula (I), which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
摘要翻译: 作为Pi3K / Akt途径的有效抑制剂的式(I)化合物处理其生产和用作药物。
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公开(公告)号:US20140113901A1
公开(公告)日:2014-04-24
申请号:US14007427
申请日:2011-04-07
申请人: Lars Bärfacker , William Sott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Hans Briem , Ulf Bömer
发明人: Lars Bärfacker , William Sott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Hans Briem , Ulf Bömer
IPC分类号: C07D487/04 , A61K45/06 , A61K31/5025
CPC分类号: C07D487/04 , A61K31/5025 , A61K45/06
摘要: Imidazopyridazines of formula (I) a process for their production and the use thereof.
摘要翻译: 式(I)的咪唑并哒嗪其制备方法及其用途。
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公开(公告)号:US20130210825A1
公开(公告)日:2013-08-15
申请号:US13812555
申请日:2011-07-27
IPC分类号: C07D487/04
CPC分类号: C07D487/04
摘要: The invention relates to imidazo[1,2-b]pyridazines of general formula (I) a process for their manufacuture and their use for the treatment of benign and malignant neoplasia.
摘要翻译: 本发明涉及通式(I)的咪唑并[1,2-b]哒嗪其制备方法及其用于治疗良性和恶性肿瘤的方法。
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公开(公告)号:US08987273B2
公开(公告)日:2015-03-24
申请号:US13812555
申请日:2011-07-27
IPC分类号: A61K31/501 , C07D237/26 , C07D487/04
CPC分类号: C07D487/04
摘要: The invention relates to imidazo[1,2-b]pyridazines of general formula (I) a process for their manufacture and their use for the treatment of benign and malignant neoplasia.
摘要翻译: 本发明涉及通式(I)的咪唑并[1,2-b]哒嗪,其制备及其用于治疗良性和恶性肿瘤的方法。
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7.SUBSTITUTED PYRIMIDO[1,2-B]INDAZOLES AND THEIR USE AS MODULATORS OF THE PI3K/AKT PATHWAY 有权
标题翻译: 取代的PYRIMIDO [1,2-B]吲哚并作为PI3K / AKT途径的调节剂使用公开(公告)号:US20130310405A1
公开(公告)日:2013-11-21
申请号:US13994517
申请日:2011-12-13
IPC分类号: C07D487/04 , A61K45/06 , A61K31/519
CPC分类号: C07D487/04 , A61K31/519 , A61K45/06
摘要: Compounds of Formula (I), which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals. The compounds of formula (I) a: useful for the treatment of cancer.
摘要翻译: 作为Pi3K / Akt途径的有效抑制剂的式(I)化合物可用于生产和用作药物。 式(I)的化合物a:可用于治疗癌症。
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8.Substituted pyrimido[1,2-b]indazoles and their use as modulators of the Pi3K/Akt pathway 有权
标题翻译: 取代的嘧啶并[1,2-b]吲唑及其作为Pi3K / Akt途径的调节剂的用途公开(公告)号:US08987286B2
公开(公告)日:2015-03-24
申请号:US13994517
申请日:2011-12-13
IPC分类号: C07D487/04 , A61K31/519 , A61K45/06
CPC分类号: C07D487/04 , A61K31/519 , A61K45/06
摘要: Compounds of Formula (I), which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals. The compounds of formula (I) a: useful for the treatment of cancer.
摘要翻译: 作为Pi3K / Akt途径的有效抑制剂的式(I)化合物可用于生产和用作药物。 式(I)的化合物a:可用于治疗癌症。
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9.Benzyl amines, a process for their production and their use as anti-inflammatory agents 有权
标题翻译: 苄胺,其生产方法及其用作抗炎剂公开(公告)号:US08461346B2
公开(公告)日:2013-06-11
申请号:US13465746
申请日:2012-05-07
申请人: Markus Berger , Jan Dahmen , Hartmut Rehwinkel , Stefan Jaroch , Heike Schaecke
发明人: Markus Berger , Jan Dahmen , Hartmut Rehwinkel , Stefan Jaroch , Heike Schaecke
IPC分类号: C07D215/38
CPC分类号: C07C215/16 , C07B2200/07 , C07C215/28 , C07C217/70 , C07C317/28 , C07D215/38 , C07D233/84 , C07D401/12 , C07D405/12 , C07D405/14
摘要: The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
摘要翻译: 本发明涉及式I化合物,其制备方法及其作为抗炎剂的用途。
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公开(公告)号:US20120252770A1
公开(公告)日:2012-10-04
申请号:US13429177
申请日:2012-03-23
申请人: Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrencher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
发明人: Markus Berger , Jan Dahmén , Karl Edman , Anders Eriksson , Balint Gabos , Thomas Hansson , Martin Hemmerling , Krister Henriksson , Svetlana Ivanova , Matti Lepistö , Darren McKerrencher , Magnus Munck af Rosenschöld , Stinabritt Nilsson , Hartmut Rehwinkel , Camilla Taflin
IPC分类号: A61K31/416 , A61K31/5377 , A61K31/501 , A61K31/506 , A61K31/437 , A61K31/4439 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/422 , A61K31/4196 , A61K31/4184 , C07D413/10 , C07D401/04 , C07D471/04 , C07D401/12 , C07D417/12 , C07D413/12 , A61K31/4192 , C07D231/56 , A61P29/00 , A61P11/06 , A61P11/00 , C07D405/12 , C07D403/12 , C07D409/12 , C07D417/14 , A61K31/56
CPC分类号: C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要: Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
摘要翻译: 式(I)化合物:本发明涉及新的吲唑基酯或酰胺衍生物,包含这些衍生物的药物组合物,制备这种新型衍生物的方法以及使用这些衍生物作为药物
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