公开(公告)号：US06582720B1

公开(公告)日：2003-06-24

申请号：US09600885

申请日：2000-09-07

申请人： Toshio Inagi ,  Hiroyuki Shirai ,  Norikazu Yamaguchi ,  Takeshi Nishino

发明人： Toshio Inagi ,  Hiroyuki Shirai ,  Norikazu Yamaguchi ,  Takeshi Nishino

IPC分类号： A61F1300

CPC分类号： A61K9/0065 ,  A61K9/5026

摘要： The present invention provides a gastric and/or duodenal adhesive pharmaceutical composition obtained by coating a composition, which comprises a medicament acting at the stomach and/or duodenum and one or more of ingredients selected from water insoluble polymers, polyglycerin fatty acid esters, lipids and waxes, with a polymer having adhesive capacity onto the surface of the mucosa of a digestive tract under acid conditions and separates from the mucosa of the digestive tract in neutral or alkaline conditions. This composition adheres only to the mucosa of the stomach and/or duodenum and releases the medicament over long hours so that sufficient effects are available by a small amount of the medicament.

摘要翻译： 本发明提供通过包衣组合物获得的胃和/或十二指肠粘合剂药物组合物，所述组合物包含在胃和/或十二指肠作用的药物和一种或多种选自水不溶性聚合物，聚甘油脂肪酸酯，脂质和 蜡，具有粘合能力的聚合物在酸性条件下在消化道粘膜的表面上，并在中性或碱性条件下与消化道粘膜分离。 该组合物仅粘附到胃和/或十二指肠的粘膜上并在长时间内释放药物，以便通过少量药物获得足够的效果。