公开(公告)号：US08105630B2

公开(公告)日：2012-01-31

申请号：US10554921

申请日：2004-04-28

申请人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Toshio Inagi ,  Hirofumi Takeuchi ,  Tsutomu Kajino ,  Yoshiaki Fukushima ,  Haruo Takahashi

发明人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Toshio Inagi ,  Hirofumi Takeuchi ,  Tsutomu Kajino ,  Yoshiaki Fukushima ,  Haruo Takahashi

IPC分类号： A61K31/50 ,  A61K9/00

CPC分类号： A61K31/50 ,  A61K9/1611 ,  A61K9/1694 ,  A61K9/2077 ,  Y10S977/906

摘要： A composition containing an extremely poorly water-soluble drug and obtained by treating, with a supercritical fluid or subcritical fluid of carbon dioxide, a mixture comprising a porous silica material and the extremely poorly water-soluble drug; and its production process. The porous silica material has an average pore diameter in a range of from 1 to 20 nm, pores having diameters within ±40% of the average pore size account for at least 60% of a total pore volume of the porous silica material, and in X-ray diffractometry, the porous silica material has at least one peak at a position of diffraction angle (2θ) corresponding to a d value of at least 1 nm.The composition according to the present invention, which contains the extremely poorly water-soluble drug, is excellent in the dissolution of the extremely poorly water-soluble drug.

摘要翻译： 通过用超临界流体或二临界流体二氧化碳处理包含多孔二氧化硅材料和极难水溶性药物的混合物获得的组合物，其含有极差水溶性药物， 及其生产工艺。 多孔二氧化硅材料的平均孔径在1至20nm的范围内，直径在平均孔径的±40％范围内的孔占多孔二氧化硅材料的总孔体积的至少60％，并且在 X射线衍射法，多孔二氧化硅材料在与至少1nm的ad值相对应的衍射角（2θ）处具有至少一个峰。 含有极差水溶性药物的本发明组合物，极难溶于水的药物溶解性优异。

公开(公告)号：US06582720B1

公开(公告)日：2003-06-24

申请号：US09600885

申请日：2000-09-07

申请人： Toshio Inagi ,  Hiroyuki Shirai ,  Norikazu Yamaguchi ,  Takeshi Nishino

发明人： Toshio Inagi ,  Hiroyuki Shirai ,  Norikazu Yamaguchi ,  Takeshi Nishino

IPC分类号： A61F1300

CPC分类号： A61K9/0065 ,  A61K9/5026

摘要： The present invention provides a gastric and/or duodenal adhesive pharmaceutical composition obtained by coating a composition, which comprises a medicament acting at the stomach and/or duodenum and one or more of ingredients selected from water insoluble polymers, polyglycerin fatty acid esters, lipids and waxes, with a polymer having adhesive capacity onto the surface of the mucosa of a digestive tract under acid conditions and separates from the mucosa of the digestive tract in neutral or alkaline conditions. This composition adheres only to the mucosa of the stomach and/or duodenum and releases the medicament over long hours so that sufficient effects are available by a small amount of the medicament.

摘要翻译： 本发明提供通过包衣组合物获得的胃和/或十二指肠粘合剂药物组合物，所述组合物包含在胃和/或十二指肠作用的药物和一种或多种选自水不溶性聚合物，聚甘油脂肪酸酯，脂质和 蜡，具有粘合能力的聚合物在酸性条件下在消化道粘膜的表面上，并在中性或碱性条件下与消化道粘膜分离。 该组合物仅粘附到胃和/或十二指肠的粘膜上并在长时间内释放药物，以便通过少量药物获得足够的效果。

公开(公告)号：US4309414A

公开(公告)日：1982-01-05

申请号：US87574

申请日：1979-10-23

申请人： Toshio Inagi ,  Toyojiro Muramatsu ,  Hidetaka Nagai

发明人： Toshio Inagi ,  Toyojiro Muramatsu ,  Hidetaka Nagai

IPC分类号： A61K31/405 ,  A61K45/08 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38 ,  A61K31/40 ,  A61K31/78

CPC分类号： A61K47/38 ,  A61K31/405 ,  A61K47/18 ,  A61K47/32 ,  A61K9/0014

摘要： An antiinflammatory analgesic gelled ointment is disclosed which comprises indomethacin, a medium consisting of a glycol, alcohol and water, a gelling agent selected from cellulose and a carboxyvinyl polymer which has been neutralized with an amine, and water sufficiently enough to make up the balance. Such gelled ointment has an excellent antiinflammatory activity.

摘要翻译： 公开了一种消炎止痛凝胶软膏，其包含吲哚美辛，由二醇，醇和水组成的培养基，选自纤维素和已用胺中和的羧基乙烯基聚合物的胶凝剂，以及足够足以构成平衡的水。 这种凝胶软膏具有优异的抗炎活性。

公开(公告)号：US20120328675A1

公开(公告)日：2012-12-27

申请号：US13582689

申请日：2011-03-03

申请人： Tsutomu Awamura ,  Hisanobu Nishikawa ,  Kazuhiko Kokaji ,  Akihiro Ishise ,  Takayuki Arai ,  Seiji Miura ,  Toshio Inagi

发明人： Tsutomu Awamura ,  Hisanobu Nishikawa ,  Kazuhiko Kokaji ,  Akihiro Ishise ,  Takayuki Arai ,  Seiji Miura ,  Toshio Inagi

IPC分类号： A61K9/00 ,  A61P1/12 ,  A61K31/426 ,  A61P29/00 ,  A61K31/47 ,  A61P3/06 ,  A61K31/451 ,  A61K31/192

CPC分类号： A61K31/045 ,  A61K9/006

摘要： Provided is a film preparation in which an unpleasant taste derived from a medicament is masked. The film preparation includes coating layers containing no terpene formed on both sides of a medicament-containing layer containing a medicament having an unpleasant taste and a terpene.

摘要翻译： 提供了一种其中掩盖衍生自药物的不愉快味道的膜制剂。 膜制剂包括不含萜烯的包衣层，其含有含有不愉快味道的药物和萜烯的药物含有层的两侧。

公开(公告)号：US20110034859A1

公开(公告)日：2011-02-10

申请号：US12988047

申请日：2009-04-17

申请人： Kenichi Suzuki ,  Makoto Kanebako ,  Toshio Inagi

发明人： Kenichi Suzuki ,  Makoto Kanebako ,  Toshio Inagi

IPC分类号： A61N1/30 ,  A61K33/00

CPC分类号： A61K45/06 ,  A61K9/0009 ,  A61K9/0041 ,  A61K31/555 ,  A61K31/675 ,  A61K33/24 ,  A61N1/044 ,  A61N1/0448 ,  A61K2300/00

摘要： Provided is to enhance the therapeutic effect of an iontophoretic preparation for treatment of breast cancer or mastitis.An iontophoretic preparation for treatment of breast cancer and/or mastitis containing, as an active ingredient, a nonsteroidal anti-inflammatory analgesic agent and/or an anticancer agent, wherein an electrolyte is topically administered through the nipple part into the mammary gland; subsequently, a donor is applied to the nipple part; and the active ingredient is topically administered through the nipple part into the mammary gland by application of current.

摘要翻译： 提供用于治疗乳腺癌或乳腺炎的离子电渗疗法的治疗效果。 一种用于治疗乳腺癌和/或乳腺炎的离子电渗疗法制剂，其包含作为活性成分的非甾体抗炎止痛剂和/或抗癌剂，其中电解质通过乳头部分局部施用到乳腺中; 随后，将供体施加到乳头部分; 并且活性成分通过施加电流通过乳头部分局部施用到乳腺中。

公开(公告)号：US20060293327A1

公开(公告)日：2006-12-28

申请号：US10554921

申请日：2004-04-28

申请人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Toshio Inagi ,  Hirofumi Takeuichi ,  Tsutomu Kajino ,  Yoshiaki Fukushima ,  Haruo Takahashi

发明人： Hiroshi Miura ,  Makoto Kanebako ,  Masayuki Kanishi ,  Toshio Inagi ,  Hirofumi Takeuichi ,  Tsutomu Kajino ,  Yoshiaki Fukushima ,  Haruo Takahashi

IPC分类号： A61K31/50 ,  A61K9/00

CPC分类号： A61K31/50 ,  A61K9/1611 ,  A61K9/1694 ,  A61K9/2077 ,  Y10S977/906

摘要： A composition containing an extremely poorly water-soluble drug and obtained by treating, with a supercritical fluid or subcritical fluid of carbon dioxide, a mixture comprising a porous silica material and the extremely poorly water-soluble drug; and its production process. The porous silica material has an average pore diameter in a range of from 1 to 20 nm, pores having diameters within ±40% of the average pore size account for at least 60% of a total pore volume of the porous silica material, and in X-ray diffractometry, the porous silica material has at least one peak at a position of diffraction angle (2θ) corresponding to a d value of at least 1 nm. The composition according to the present invention, which contains the extremely poorly water-soluble drug, is excellent in the dissolution of the extremely poorly water-soluble drug.

摘要翻译： 通过用超临界流体或二临界流体二氧化碳处理包含多孔二氧化硅材料和极难水溶性药物的混合物获得的组合物，其含有极差的水溶性药物， 及其生产工艺。 多孔二氧化硅材料的平均孔径在1至20nm的范围内，直径在平均孔径的±40％范围内的孔占多孔二氧化硅材料的总孔体积的至少60％，并且在 X射线衍射法，多孔二氧化硅材料在衍射角（2θ）的至少1nm的ad值处具有至少一个峰。 含有极差水溶性药物的本发明组合物，极难溶于水的药物溶解性优异。

公开(公告)号：US4525347A

公开(公告)日：1985-06-25

申请号：US468491

申请日：1983-02-22

申请人： Toshio Inagi ,  Toyojiro Muramatsu ,  Hidetaka Nagai

发明人： Toshio Inagi ,  Toyojiro Muramatsu ,  Hidetaka Nagai

IPC分类号： A61K31/405 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38 ,  A61K31/40 ,  A61K31/78

CPC分类号： A61K31/405 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38 ,  A61K9/0014

摘要： An antiinflammatory analgesic ointment comprising: (a) an antiinflammatory amount of indomethacin; (b) a medium consisting of a hydroxy compound in the range of from 15 to 85% by weight, water in the range of 30 to 55% by weight and a gelating agent being present in an amount sufficient to effect gelation of said ointment and selected from the group consisting of a cellulose compound and a carboxyvinyl polymer which has been neutralized with aqueous ammonia or an amine; (c) an adjuvant being present in the range of from 0.5 to 5% by weight and selected from the group consisting of a C.sub.1 -C.sub.5 alcohol ester of a C.sub.4 -C.sub.14 monocarboxylic acid and a C.sub.1 -C.sub.3 alcohol diester of a C.sub.4 -C.sub.10 dicarboxylic acid; and (d) water in an amount sufficient to make up the balance of the ointment, said ointment being adjusted in its pH from an acidic to slightly basic level sufficient to solubilize said indomethacin in the composition but not too basic a pH level to cause decomposition of said indomethacin.

摘要翻译： 一种抗炎止痛软膏，其包含：（a）抗炎剂量的吲哚美辛; （b）由15至85重量％的羟基化合物，30至55重量％的水和80至55重量％的水，和足以使所述软膏发生凝胶化的量的凝胶剂， 选自纤维素化合物和已经用氨水或胺中和的羧基乙烯基聚合物; （c）佐剂以0.5-5重量％的范围存在，并且选自C 4 -C 14单羧酸的C 1 -C 5醇酯和C 4 -C 10的C 1 -C 3醇二酯 二羧酸 和（d）足以构成软膏平衡的量的水，所述软膏的pH值从酸性至碱性水平调节至足以将所述吲哚美辛溶解于组合物中，但不过多碱性的pH值导致分解 的所述吲哚美辛。

公开(公告)号：US08442629B2

公开(公告)日：2013-05-14

申请号：US12988047

申请日：2009-04-17

申请人： Kenichi Suzuki ,  Makoto Kanebako ,  Toshio Inagi

发明人： Kenichi Suzuki ,  Makoto Kanebako ,  Toshio Inagi

IPC分类号： A61N1/30 ,  A61K33/00

CPC分类号： A61K45/06 ,  A61K9/0009 ,  A61K9/0041 ,  A61K31/555 ,  A61K31/675 ,  A61K33/24 ,  A61N1/044 ,  A61N1/0448 ,  A61K2300/00

摘要： Provided is to enhance the therapeutic effect of an iontophoretic preparation for treatment of breast cancer or mastitis.An iontophoretic preparation for treatment of breast cancer and/or mastitis containing, as an active ingredient, a nonsteroidal anti-inflammatory analgesic agent and/or an anticancer agent, wherein an electrolyte is topically administered through the nipple part into the mammary gland; subsequently, a donor is applied to the nipple part; and the active ingredient is topically administered through the nipple part into the mammary gland by application of current.

摘要翻译： 提供用于治疗乳腺癌或乳腺炎的离子电渗疗法的治疗效果。 一种用于治疗乳腺癌和/或乳腺炎的离子电渗疗法制剂，其包含作为活性成分的非甾体抗炎止痛剂和/或抗癌剂，其中电解质通过乳头部分局部施用到乳腺中; 随后，将供体施加到乳头部分; 并且活性成分通过施加电流通过乳头部分局部施用到乳腺中。

公开(公告)号：US08362027B2

公开(公告)日：2013-01-29

申请号：US13204803

申请日：2011-08-08

申请人： Toshio Inagi ,  Makoto Kanebako ,  Hiroshi Terada ,  Kimiko Makino ,  Masakazu Toi

发明人： Toshio Inagi ,  Makoto Kanebako ,  Hiroshi Terada ,  Kimiko Makino ,  Masakazu Toi

IPC分类号： A61K31/675 ,  A61K31/405 ,  A61K31/513 ,  C07D209/26 ,  C07D239/553 ,  C07F9/6584

CPC分类号： A61K9/0009 ,  A61K31/405 ,  A61N1/30

摘要： The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing them efficiently to arrive into the mammary gland. The present invention provides an iontophoretic preparation for treating breast cancer and/or mastitis which contains a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent as an active ingredient and has a donor to be applied on a nipple part for topical administration of the active ingredient from the nipple part to the mammary gland by application of electric potential.

摘要翻译： 本发明提供通过局部施用非甾体抗炎止痛剂和/或抗癌剂并使其有效地进入乳腺来治疗乳腺癌和/或乳腺炎的方法。 本发明提供了一种用于治疗乳腺癌和/或乳腺炎的离子电渗疗法，其包含非甾体抗炎止痛剂和/或抗癌剂作为活性成分，并且具有施用于乳头部分的供体，用于局部施用 通过施加电位从乳头部分到乳腺的活性成分。

公开(公告)号：US07553865B2

公开(公告)日：2009-06-30

申请号：US10521958

申请日：2003-07-22

申请人： Hiroyuki Shirai ,  Tatsuya Nakai ,  Masami Serizawa ,  Yasuo Shinoda ,  Toshio Inagi

发明人： Hiroyuki Shirai ,  Tatsuya Nakai ,  Masami Serizawa ,  Yasuo Shinoda ,  Toshio Inagi

IPC分类号： A61K31/40 ,  A01N43/38 ,  C07D209/26

CPC分类号： A61K9/06 ,  A61K9/0014 ,  A61K31/405 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/32 ,  A61K47/38 ,  A61K47/44

摘要： An object of the present invention is to provide an indomethacin external preparation that has an excellent use feeling and excellent absorbability and causes no phase separation into an oil layer and an aqueous layer, thus exhibiting satisfactory stability of preparation with time. Provided is an indomethacin external preparation containing: 0.1 to 3 wt % of indomethacin; 25 to 50 wt % of alcohol; 0.01 to 5 wt % of gelling agent; 5 to 30 wt % of oil component; 20 to 50 wt % of water; and 0.01 to 10 wt % of one or more components selected from the group consisting of glyceryl monostearate, sorbitan monostearate, stearyl alcohol, and polyethylene glycol monostearate.

摘要翻译： 本发明的目的是提供具有优异的使用感和优异的吸收性的吲哚美辛外用制剂，并且不会使相分离成油层和水层，从而表现出令人满意的制备时间稳定性。 本发明提供消炎痛外用制剂，含有0.1〜3重量％的吲哚美辛; 25〜50重量％的醇; 0.01〜5重量％的胶凝剂; 5〜30重量％的油成分; 20〜50重量％的水; 和0.01〜10重量％的选自单硬脂酸甘油酯，脱水山梨糖醇单硬脂酸酯，硬脂醇和聚乙二醇单硬脂酸酯的一种或多种成分。