公开(公告)号：US5762929A

公开(公告)日：1998-06-09

申请号：US508952

申请日：1995-07-31

申请人： Masao Kinoshita ,  Yasuo Iwasaki ,  Ken Ikeda ,  Toshiya Shiojima ,  Nozomu Tagaya ,  Tomoko Kobayashi

发明人： Masao Kinoshita ,  Yasuo Iwasaki ,  Ken Ikeda ,  Toshiya Shiojima ,  Nozomu Tagaya ,  Tomoko Kobayashi

IPC分类号： A61K38/00 ,  A61K38/44 ,  A61P21/00 ,  C12N9/02 ,  C12N9/96 ,  A61K38/54

CPC分类号： C12N9/0089 ,  C12N9/96 ,  A61K38/00

摘要： The present invention relates to an novel anti-motoneuron-disease agent, comprising superoxide dismutase conjugated with lecithin through chemical crosslinking represented in the following generic formula (PC-SOD) as an effective ingredient: SOD--�C(O)--(CH.sub.2).sub.n --C(O)--X!.sub.m wherein SOD represents superoxide dismutase and X represents a residue of lysolecithin having a hydroxy group at position 2 of glycerol whose hydrogen atom of the hydroxyl group at position 2 is removed. A pharmaceutical agent of the present invention may improve symptoms of motoneuron diseases such as amyotrophic lateral sclerosis etc. by oral or parenteral administration. The present invention also relates to a novel treatment method for motoneuron disease by administrating PC-SOD and novel use of PC-SOD as a medical composition for preparing an agent for treating motoneuron disease.

摘要翻译： 本发明涉及一种新型抗运动神经元疾病药物，其包含通过以下通式（PC-SOD）表示的化学交联作为有效成分与卵磷脂缀合的超氧化物歧化酶：SOD- [C（O） - （CH 2） nC（O）-X] m，其中SOD表示超氧化物歧化酶，X表示除去位置2的羟基的甘油的位置2具有羟基的溶血卵磷脂的残基。 本发明的药剂可以通过口服或肠胃外给药改善运动神经元疾病如肌萎缩性侧索硬化等的症状。 本发明还涉及通过施用PC-SOD的运动神经元疾病的新颖治疗方法和PC-SOD的新型用作制备治疗运动神经元疾病的药物的医药组合物。