公开(公告)号：US20160143900A1

公开(公告)日：2016-05-26

申请号：US14900666

申请日：2014-06-24

申请人： Harold C. SMITH ,  Ryan P. BENNETT ,  OYAGEN, INC.

发明人： Harold C. SMITH ,  Ryan P. BENNETT

IPC分类号： A61K31/4745 ,  G01N33/68 ,  A61K45/06

CPC分类号： A61K31/4745 ,  A61K45/06 ,  G01N33/6845 ,  G01N2333/15 ,  G01N2333/163 ,  G01N2500/02 ,  G01N2500/10

摘要： The present invention relates to the use of camptothecin derivatives as anti-HIV agents that disrupt self-association of the viral infectivity factor (Vif) found in HIV and other retroviruses. The present invention also relates to methods of identifying agents that disrupt VIf self-association and methods of using these agents, including methods of treating or preventing HIV infection.

摘要翻译： 本发明涉及喜树碱衍生物作为抗HIV试剂的用途，其破坏HIV和其他逆转录病毒中发现的病毒感染因子（Vif）的自身结合。 本发明还涉及鉴定破坏VIf自身结合的药剂的方法以及使用这些药物的方法，包括治疗或预防HIV感染的方法。

公开(公告)号：US11617753B2

公开(公告)日：2023-04-04

申请号：US16348867

申请日：2017-11-06

申请人： OYAGEN, INC. ,  The United States of America, as represented by the Secretary of Health and Human Services

发明人： Harold C. Smith ,  Ryan P. Bennett ,  Peter Jahrling

IPC分类号： A61K31/52 ,  A61K31/7064

摘要： Disclosed herein are methods for treating an Ebola virus and inhibiting the transmission and propagation thereof.

公开(公告)号：US20220378815A1

公开(公告)日：2022-12-01

申请号：US17880464

申请日：2022-08-03

申请人： OYAGEN, INC.

发明人： Harold C. Smith ,  Ryan P. Bennett

IPC分类号： A61K31/7064 ,  A61K31/706 ,  A61K9/00 ,  A61P31/14

摘要： Disclosed herein are methods, formulations, and kits for treating coronavirus infections, including Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infections and SARS-CoV-2 infections. Further disclosed are stop-gap methods for controlling the spread of coronavirus infections and the emergence of drug resistant strains of coronavirus.

公开(公告)号：US20230233591A1

公开(公告)日：2023-07-27

申请号：US17918970

申请日：2021-04-14

申请人： OYAGEN, INC.

发明人： Harold C. Smith ,  Ryan P. Bennett

IPC分类号： A61K31/7064 ,  A61P31/12

CPC分类号： A61K31/7064 ,  A61P31/12

摘要： Disclosed herein are methods, compositions and kits for treating and inhibiting Poxviridae virus infections, for example, Vaccinia virus infections. Further disclosed are stop-gap methods for controlling the spread of Poxviridae virus infections.

公开(公告)号：US20210236497A1

公开(公告)日：2021-08-05

申请号：US16851047

申请日：2020-04-16

申请人： OYAGEN, INC.

发明人： Harold C. SMITH ,  Ryan P. BENNETT

IPC分类号： A61K31/519 ,  A61P31/14

摘要： Disclosed herein are methods, formulations, and kits for treating coronavirus infections, including Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infections. Further disclosed are stop-gap methods for controlling the spread of coronavirus infections and the emergence of drug resistant strains of coronavirus.

公开(公告)号：US11779585B2

公开(公告)日：2023-10-10

申请号：US17880464

申请日：2022-08-03

申请人： OYAGEN, INC.

发明人： Harold C. Smith ,  Ryan P. Bennett

IPC分类号： A01N43/04 ,  A61K31/70 ,  A61K31/519 ,  A61P31/14 ,  A61K31/706 ,  A61K31/7064 ,  A61K9/20 ,  A61K9/00 ,  A61K9/48

CPC分类号： A61K31/519 ,  A61K31/706 ,  A61K31/7064 ,  A61P31/14 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/20 ,  A61K9/4808

摘要： Disclosed herein are methods, formulations, and kits for treating coronavirus infections, including Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infections and SARS-CoV-2 infections. Further disclosed are stop-gap methods for controlling the spread of coronavirus infections and the emergence of drug resistant strains of coronavirus.

公开(公告)号：US20230285434A1

公开(公告)日：2023-09-14

申请号：US17918964

申请日：2021-04-14

申请人： OYAGEN, INC.

发明人： Harold C. Smith ,  Ryan P. Bennett

IPC分类号： A61K31/7064 ,  A61P31/14

CPC分类号： A61K31/7064 ,  A61P31/14

摘要： Disclosed herein are methods, compositions and kits for treating and inhibiting Arenaviridae virus infections and their associated diseases, such as Lassa fever caused by the Lassa virus (LASV).

公开(公告)号：US11738025B2

公开(公告)日：2023-08-29

申请号：US16851047

申请日：2020-04-16

申请人： OYAGEN, INC.

发明人： Harold C. Smith ,  Ryan P. Bennett

IPC分类号： A61P31/14 ,  A61K31/7052 ,  A61K31/7056 ,  A61K31/519 ,  A61K31/706 ,  A61K31/7064 ,  A61K9/20 ,  A61K9/00 ,  A61K9/48

CPC分类号： A61K31/519 ,  A61K31/706 ,  A61K31/7064 ,  A61P31/14 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0053 ,  A61K9/20 ,  A61K9/4808

摘要： Disclosed herein are methods, formulations, and kits for treating coronavirus infections, including Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infections. Further disclosed are stop-gap methods for controlling the spread of coronavirus infections and the emergence of drug resistant strains of coronavirus.

公开(公告)号：US20220000860A1

公开(公告)日：2022-01-06

申请号：US17474895

申请日：2021-09-14

申请人： OYAGEN, INC.

发明人： Harold C. SMITH ,  Ryan P. BENNETT

IPC分类号： A61K31/4745 ,  A61K45/06

摘要： Disclosed herein are compounds useful for treating and/or preventing HIV infections and the transmission of HIV from an infected subject.

公开(公告)号：US11116762B2

公开(公告)日：2021-09-14

申请号：US16476094

申请日：2018-01-02

申请人： OYAGEN, INC.

发明人： Harold C. Smith ,  Ryan P. Bennett

IPC分类号： A61K31/4745 ,  A61K45/06 ,  A61P31/18

摘要： Disclosed herein are compounds useful for treating and/or preventing HIV infections and the transmission of HIV from an infected subject.