公开(公告)号：US4319052A

公开(公告)日：1982-03-09

申请号：US822374

申请日：1977-08-05

申请人： Evgeny L. Styskin ,  Yakov A. Gurvich ,  Simona T. Kumok ,  Olga F. Starikova ,  Grigory I. Rutman ,  Jury I. Michurov ,  Vladimir A. Yanshevsky ,  Vladimir K. Gusev ,  Alexandr G. Liakumovich

发明人： Evgeny L. Styskin ,  Yakov A. Gurvich ,  Simona T. Kumok ,  Olga F. Starikova ,  Grigory I. Rutman ,  Jury I. Michurov ,  Vladimir A. Yanshevsky ,  Vladimir K. Gusev ,  Alexandr G. Liakumovich

IPC分类号： C07C37/00 ,  C07C37/11 ,  C07C37/20 ,  C07C39/14

CPC分类号： C07C37/115 ,  C07C37/20 ,  C07C2101/14

摘要： A method for preparing sterically hindered bis- or polyphenols of the formula: ##STR1## wherein R' is hydrogen, a C.sub.1 -C.sub.4 alkyl; R" and R"' the same or different and are each: ##STR2## wherein R is a tertiary C.sub.4 -C.sub.8 alkyl, R.sub.1 and R.sub.2 are the same or different and represent a C.sub.1 -C.sub.8 alkyl or a C.sub.6 -C.sub.8 cycloalkyl, or a C.sub.7 -C.sub.9 aralkyl, which comprises reacting the starting sterically hindered 2,4,6-trialkylphenols of the formula: ##STR3## wherein A is a C.sub.1 -C.sub.8 alkyl or a C.sub.6 -C.sub.8 cycloalkyl or a C.sub.7 -C.sub.9 aralkyl or a 3,5-dialkyl-2-hydroxybenzyl of the formula: ##STR4## B is a C.sub.1 -C.sub.8 alkyl, or a C.sub.6 -C.sub.8 cycloalkyl, or a C.sub.7 -C.sub.9 aralkyl, or a 3,5-dialkyl-4-hydroxybenzyl of the formula: ##STR5## wherein R.sub.1 and R are as identified above, with acetals, aldehydes or donors of C.sub.1 -C.sub.5 aldehydes in an acidic medium at a temperature within the range of from 60.degree. to 200.degree. C. in the presence of an acidic catalyst, followed by isolation of the desired product.The method according to the present invention makes it possible to prepare sterically hindered bis- or polyphenols in a single stage, whereby the process technology is substantially simplified as compared to those of the prior art. The method of the present invention precludes formation of waste water and atmospheric pollutants. The method ensures preparation of the desired products possessing high quality in high yield without any additional crystallization.

摘要翻译： 制备下式的空间位阻双酚或多酚的方法：其中R'是氢，C1-C4烷基; R“和R”相同或不同，各自为：其中R为叔C4-C8烷基，R1和R2相同或不同，表示C1-C8烷基或 C 6 -C 8环烷基或C 7 -C 9芳烷基，其包括使下式的起始空间位阻2,4,6-三烷基酚与其反应：其中A是C1-C8烷基或C6-C8环烷基或 C7-C9芳烷基或下式的3,5-二烷基-2-羟基苄基：B是C 1 -C 8烷基或C 6 -C 8环烷基或C 7 -C 9芳烷基， 下式的二烷基-4-羟基苄基：其中R1和R如上所定义，在酸性介质中在60至200℃的温度范围内与C1-C5醛的缩醛，醛或供体 在酸性催化剂存在下，然后分离所需产物。 根据本发明的方法使得可以在单个阶段中制备空间位阻双酚或多酚，由此与现有技术相比，工艺技术被大大简化。 本发明的方法排除了废水和大气污染物的形成。 该方法可确保以高产率制备具有高质量的所需产品，而无需任何额外的结晶。