公开(公告)号：US20140051676A1

公开(公告)日：2014-02-20

申请号：US14054221

申请日：2013-10-15

Applicant: Oliver BARKER ,  Jonathan Mark BENTLY ,  Mark Gary BOCK ,  Thomas CAIN ,  Praful CHOVATIA ,  Jennifer Ruth DOD ,  Florence EUSTACHE ,  Laura GLEAVE ,  Jonathan HARGRAVE ,  Alexander HEIFETZ ,  Richard LAW ,  Ali RAOOF ,  David WILLOWS

Inventor： Oliver BARKER ,  Jonathan Mark BENTLY ,  Mark Gary BOCK ,  Thomas CAIN ,  Praful CHOVATIA ,  Jennifer Ruth DOD ,  Florence EUSTACHE ,  Laura GLEAVE ,  Jonathan HARGRAVE ,  Alexander HEIFETZ ,  Richard LAW ,  Ali RAOOF ,  David WILLOWS

IPC: C07D413/04 ,  A61K31/53 ,  A61K45/06 ,  C07D451/02 ,  C07D491/107 ,  C07D487/04 ,  C07D498/08 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D413/14 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/5386 ,  A61K45/06 ,  C07D413/04 ,  C07D417/14 ,  C07D451/02 ,  C07D487/04 ,  C07D491/10 ,  C07D491/107 ,  C07D498/08

Abstract: The invention relates to new derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of chronic pain.

公开(公告)号：US20150025057A1

公开(公告)日：2015-01-22

申请号：US14509705

申请日：2014-10-08

Applicant: Oliver BARKER ,  Jonathan Mark BENTLY ,  Mark Gary BOCK ,  Thomas CAIN ,  Praful CHOVATIA ,  Jennifer Ruth DOD ,  Florence EUSTACHE ,  Laura GLEAVE ,  Jonathan HARGRAVE ,  Alexander HEIFETZ ,  Richard LAW ,  Ali RAOOF ,  David WILLOWS

Inventor： Oliver BARKER ,  Jonathan Mark BENTLY ,  Mark Gary BOCK ,  Thomas CAIN ,  Praful CHOVATIA ,  Jennifer Ruth DOD ,  Florence EUSTACHE ,  Laura GLEAVE ,  Jonathan HARGRAVE ,  Alexander HEIFETZ ,  Richard LAW ,  Ali RAOOF ,  David WILLOWS

IPC: C07D413/14 ,  A61K45/06 ,  C07D413/04 ,  A61K31/5386 ,  A61K31/5377 ,  C07D451/02 ,  C07D491/107 ,  C07D498/08 ,  A61K31/53 ,  C07D417/14

CPC classification number: C07D413/14 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/5386 ,  A61K45/06 ,  C07D413/04 ,  C07D417/14 ,  C07D451/02 ,  C07D487/04 ,  C07D491/10 ,  C07D491/107 ,  C07D498/08

Abstract: The invention relates to new derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of chronic pain.

Abstract translation: 本发明涉及式（I）的新衍生物，其中取代基如说明书中所定义; 制备此类衍生物的方法; 包含这些衍生物的药物组合物; 这种衍生物作为药物; 用于治疗慢性疼痛的衍生物。

公开(公告)号：US08895733B2

公开(公告)日：2014-11-25

申请号：US14054221

申请日：2013-10-15

Applicant: Oliver Barker ,  Jonathan Mark Bentley ,  Mark G. Bock ,  Thomas Cain ,  Praful Chovatia ,  Jennifer Ruth Dod ,  Florence Eustache ,  Laura Gleave ,  Jonathan Hargrave ,  Alexander Heifetz ,  Richard Law ,  Ali Raoof ,  David Willows

Inventor： Oliver Barker ,  Jonathan Mark Bentley ,  Mark G. Bock ,  Thomas Cain ,  Praful Chovatia ,  Jennifer Ruth Dod ,  Florence Eustache ,  Laura Gleave ,  Jonathan Hargrave ,  Alexander Heifetz ,  Richard Law ,  Ali Raoof ,  David Willows

IPC: C07D413/04 ,  C07D413/14 ,  A61K31/53 ,  A61P29/00 ,  A61K45/06 ,  C07D498/08 ,  C07D491/10 ,  C07D451/02 ,  C07D491/107 ,  C07D417/14 ,  C07D487/04

CPC classification number: C07D413/14 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/5386 ,  A61K45/06 ,  C07D413/04 ,  C07D417/14 ,  C07D451/02 ,  C07D487/04 ,  C07D491/10 ,  C07D491/107 ,  C07D498/08

Abstract: The invention relates to new derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of chronic pain.

Abstract translation: 本发明涉及式（I）的新衍生物，其中取代基如说明书中所定义; 制备此类衍生物的方法; 包含这些衍生物的药物组合物; 这种衍生物作为药物; 用于治疗慢性疼痛的衍生物。