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公开(公告)号：US20050209255A1
公开(公告)日：2005-09-22
申请号：US11046664
申请日：2005-01-26
申请人： Juan-Miguel Jimenez , Sanjay Patel , David Kay , Ronald Knegtel , Oliver Philps
发明人： Juan-Miguel Jimenez , Sanjay Patel , David Kay , Ronald Knegtel , Oliver Philps
IPC分类号： A61K31/519 , C07D403/12 , C07D471/04 , C07D487/04 , C07D487/12 , C07D487/14
CPC分类号： C07D403/12 , C07D471/04 , C07D487/04 , C07D487/12
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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2.发明授权公开(公告)号：US07855214B2
公开(公告)日：2010-12-21
申请号：US11046664
申请日：2005-01-26
申请人： Juan-Miguel Jimenez , Sanjay Patel , David Kay , Ronald Knegtel , Oliver Philps
发明人： Juan-Miguel Jimenez , Sanjay Patel , David Kay , Ronald Knegtel , Oliver Philps
IPC分类号： C07D487/22 , C07D487/14 , A61K31/519 , A61P35/00 , A61P29/00
CPC分类号： C07D403/12 , C07D471/04 , C07D487/04 , C07D487/12
摘要： The present invention relates to compounds useful as inhibitors of Tec family protein kinases. These compounds have the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, G, Cy1, and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作Tec家族蛋白激酶抑制剂的化合物。 这些化合物具有通式I或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，G，Cy 1和X如本文所定义。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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3.发明申请PROCESS FOR SYNTHESIZING ASPARTIC AND GLUTAMIC ACID DERIVATIVES ESPECIALLY USEFUL AS INTERMEDIATES IN THE MANUFACTURE OF A CASPASE INHIBITOR 审中-公开合成ASPARTIC和GLUTAMIC ACID衍生物的方法特别适用于CASPASE抑制剂制造中的中间体公开(公告)号：US20080227976A1
公开(公告)日：2008-09-18
申请号：US12030833
申请日：2008-02-13
申请人： Michael Mortimore , Oliver Philps , John Studley
发明人： Michael Mortimore , Oliver Philps , John Studley
IPC分类号： C07D243/10 , C07C229/28 , C07D209/42
CPC分类号： C07C271/20 , C07C269/06 , C07F7/1892
摘要： The invention relates to novel diazoketone derivatives. The invention also relates to processes for homologation of these diazoketone derivatives. The processes are useful for preparing compounds that are caspase inhibitors.
摘要翻译： 本发明涉及新的重氮酮衍生物。 本发明还涉及这些重氮酮衍生物的同系化方法。 该方法可用于制备作为半胱天冬酶抑制剂的化合物。
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4.发明授权Process for synthesizing aspartic and glutamic acid derivatives especially useful as intermediates in the manufacture of a caspase inhibitor 失效用于合成天冬氨酸和谷氨酸衍生物的方法，其特别可用作制备半胱天冬酶抑制剂的中间体公开(公告)号：US07335792B2
公开(公告)日：2008-02-26
申请号：US10268440
申请日：2002-10-09
申请人： Michael Mortimore , Oliver Philps , John Studley
发明人： Michael Mortimore , Oliver Philps , John Studley
IPC分类号： C07C249/00 , C07C247/00
CPC分类号： C07C271/20 , C07C269/06 , C07F7/1892
摘要： The invention relates to novel diazoketone derivatives. The invention also relates to processes for homologation of these diazoketone derivatives. The processes are useful for preparing compounds that are caspase inhibitors.
摘要翻译： 本发明涉及新的重氮酮衍生物。 本发明还涉及这些重氮酮衍生物的同系化方法。 该方法可用于制备作为半胱天冬酶抑制剂的化合物。
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