公开(公告)号：US20140255304A1

公开(公告)日：2014-09-11

申请号：US14354404

申请日：2012-10-26

申请人： Nitsch Roger ,  Christoph Hock ,  Maria Grazia Barenco Montrasio ,  Fabio Montrasio ,  Jan Grimm ,  Jean-Luc Baeriswyl ,  Paul Weinreb ,  Janaky Coomaraswamy ,  Omar Quintero-Monzon

发明人： Nitsch Roger ,  Christoph Hock ,  Maria Grazia Barenco Montrasio ,  Fabio Montrasio ,  Jan Grimm ,  Jean-Luc Baeriswyl ,  Paul Weinreb ,  Janaky Coomaraswamy ,  Omar Quintero-Monzon

IPC分类号： C07K16/18 ,  A61K47/48 ,  A61K39/395 ,  A61K51/10

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K49/16 ,  A61K51/1018 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/47 ,  G01N2800/2814

摘要： Provided are novel TDP-43-specific binding molecules including polypeptides such as human antibodies, as well as fragments, derivatives and variants thereof. Also provided are methods related to these TDP-43 specific binding molecules. Assays, kits, and solid supports related to TDP-43-specific binding molecules, including polypeptides such as, human antibodies are also disclosed. The TDP-43-specific binding molecule, antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for TDP-43 targeted immunotherapy and diagnosis, respectively.

摘要翻译： 提供了新的TDP-43特异性结合分子，包括多肽，例如人抗体，以及其片段，衍生物和变体。 还提供了与这些TDP-43特异性结合分子相关的方法。 还公开了与TDP-43特异性结合分子相关的测定，试剂盒和固体支持物，包括多肽，例如人抗体。 TDP-43特异性结合分子，抗体，免疫球蛋白链以及其结合片段，衍生物和变体可分别用于TDP-43靶向免疫治疗和诊断的药物和诊断组合物中。