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公开(公告)号：US20140255304A1
公开(公告)日：2014-09-11
申请号：US14354404
申请日：2012-10-26
申请人： Nitsch Roger , Christoph Hock , Maria Grazia Barenco Montrasio , Fabio Montrasio , Jan Grimm , Jean-Luc Baeriswyl , Paul Weinreb , Janaky Coomaraswamy , Omar Quintero-Monzon
发明人： Nitsch Roger , Christoph Hock , Maria Grazia Barenco Montrasio , Fabio Montrasio , Jan Grimm , Jean-Luc Baeriswyl , Paul Weinreb , Janaky Coomaraswamy , Omar Quintero-Monzon
IPC分类号： C07K16/18 , A61K47/48 , A61K39/395 , A61K51/10
CPC分类号： C07K16/18 , A61K39/3955 , A61K49/16 , A61K51/1018 , A61K2039/505 , A61K2039/54 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92 , G01N33/6896 , G01N2333/47 , G01N2800/2814
摘要： Provided are novel TDP-43-specific binding molecules including polypeptides such as human antibodies, as well as fragments, derivatives and variants thereof. Also provided are methods related to these TDP-43 specific binding molecules. Assays, kits, and solid supports related to TDP-43-specific binding molecules, including polypeptides such as, human antibodies are also disclosed. The TDP-43-specific binding molecule, antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for TDP-43 targeted immunotherapy and diagnosis, respectively.
摘要翻译： 提供了新的TDP-43特异性结合分子，包括多肽，例如人抗体，以及其片段，衍生物和变体。 还提供了与这些TDP-43特异性结合分子相关的方法。 还公开了与TDP-43特异性结合分子相关的测定，试剂盒和固体支持物，包括多肽，例如人抗体。 TDP-43特异性结合分子，抗体，免疫球蛋白链以及其结合片段，衍生物和变体可分别用于TDP-43靶向免疫治疗和诊断的药物和诊断组合物中。
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公开(公告)号：US09580493B2
公开(公告)日：2017-02-28
申请号：US14128497
申请日：2012-06-22
申请人： Andreas Weihofen , Jan Grimm , Christoph Hock , Roger Nitsch , Lihe Su , Paul Weinreb
发明人： Andreas Weihofen , Jan Grimm , Christoph Hock , Roger Nitsch , Lihe Su , Paul Weinreb
IPC分类号： A61K39/395 , C12P21/08 , C07K16/18 , G01N33/68
CPC分类号： C07K16/18 , A61K47/6849 , C07K2317/34 , C07K2317/565 , G01N33/6896 , G01N2333/47 , G01N2800/28 , G01N2800/2828 , G01N2800/2835
摘要： Provided are anti-human α-synuclein-specific binding molecules, e.g., antibodies or antigen-binding fragments, variants or derivatives thereof, as methods related thereto. Further provided are anti-human α-synuclein binding molecules which bind to specific N-terminal and C-terminal epitopes on human α-synuclein. The binding molecules described herein can be used in pharmaceutical and diagnostic compositions for α-synuclein targeted immunotherapy and diagnosis, respectively.
摘要翻译： 提供抗人α-突触核蛋白特异性结合分子，例如抗体或抗原结合片段，其变体或衍生物，作为与其相关的方法。 还提供了结合人α-突触核蛋白上的特异性N末端和C-末端表位的抗人α-突触核蛋白结合分子。 本文所述的结合分子可分别用于α-突触核蛋白靶向免疫治疗和诊断的药物和诊断组合物中。
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公开(公告)号：US20140369940A1
公开(公告)日：2014-12-18
申请号：US14128497
申请日：2012-06-22
申请人： Andreas Weihofen , Jan Grimm , Cristoph Hock , Roger Nitsch , Lihe Su , Paul Weinreb
发明人： Andreas Weihofen , Jan Grimm , Cristoph Hock , Roger Nitsch , Lihe Su , Paul Weinreb
CPC分类号： C07K16/18 , A61K47/6849 , C07K2317/34 , C07K2317/565 , G01N33/6896 , G01N2333/47 , G01N2800/28 , G01N2800/2828 , G01N2800/2835
摘要： Provided are anti-human α-synuclein-specific binding molecules, e.g., antibodies or antigen-binding fragments, variants or derivatives thereof, as methods related thereto. Further provided are anti-human α-synuclein binding molecules which bind to specific N-terminal and C-terminal epitopes on human α-synuclein. The binding molecules described herein can be used in pharmaceutical and diagnostic compositions for α-synuclein targeted immunotherapy and diagnosis, respectively.
摘要翻译： 提供抗人α-突触核蛋白特异性结合分子，例如抗体或抗原结合片段，其变体或衍生物，作为与其相关的方法。 还提供了结合人α-突触核蛋白上的特异性N末端和C-末端表位的抗人α-突触核蛋白结合分子。 本文所述的结合分子可分别用于α-突触核蛋白靶向免疫治疗和诊断的药物和诊断组合物中。
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公开(公告)号：US20050255102A1
公开(公告)日：2005-11-17
申请号：US10507662
申请日：2003-03-13
申请人： Shelia Violette , Paul Weinreb , Kenneth Simon , Dean Sheppard , Diane Leone
发明人： Shelia Violette , Paul Weinreb , Kenneth Simon , Dean Sheppard , Diane Leone
IPC分类号： C12N15/09 , A61K39/395 , A61K47/48 , A61K51/10 , A61P1/16 , A61P11/00 , A61P13/12 , A61P17/02 , A61P17/06 , A61P35/00 , C07K7/08 , C07K14/00 , C07K16/18 , C07K16/28 , C12N20060101 , C12N5/10 , C12N5/12 , C12Q1/02 , G01N33/574 , G01N33/68
CPC分类号： C07K16/2839 , A61K47/48507 , A61K47/48561 , A61K47/48623 , A61K47/68 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6865 , A61K51/1027 , A61K51/1066 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/205
摘要： Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % Qmediated diseases.
摘要翻译： 特异性结合M.96的单克隆抗体。 还包括使用这些抗体治疗具有或具有006介导的疾病的风险的哺乳动物或诊断％Q介导的疾病的方法。
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公开(公告)号：US20050119181A1
公开(公告)日：2005-06-02
申请号：US10956724
申请日：2004-10-01
申请人： R. Pepinsky , Alphonse Galdes , Ellen Garber , Darren Baker , Jeffery Porter , Frederick Taylor , Kevin Williams , Russell Petter , Kathryn Strauch , Paul Weinreb , Dingyi Wen , Chenhui Zeng
发明人： R. Pepinsky , Alphonse Galdes , Ellen Garber , Darren Baker , Jeffery Porter , Frederick Taylor , Kevin Williams , Russell Petter , Kathryn Strauch , Paul Weinreb , Dingyi Wen , Chenhui Zeng
CPC分类号： C07K14/46 , A61K38/1709 , C07K2319/00
摘要： Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.
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