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公开(公告)号：US20210061897A1
公开(公告)日：2021-03-04
申请号：US16997365
申请日：2020-08-19
Applicant: Genzyme Corporation , Optein, Inc.
Inventor： Steven R. Ledbetter , Celia Patricia Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ) and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
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公开(公告)号：US09481726B2
公开(公告)日：2016-11-01
申请号：US14682975
申请日：2015-04-09
Applicant: Genzyme Corporation , Optein, Inc.
Inventor： Steven R. Ledbetter , Celia Patricia Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
IPC: A61K39/395 , C07K16/22 , A61K39/00
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralize TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
Abstract translation: 本发明涉及抗体分子，特别是结合转化生长因子β（TGFβ）的抗体分子及其用途。 更具体地，本发明涉及结合并优选中和TGFβ1，TGFβ2和TGFβ3，所谓的“泛特异性”抗体分子的抗体分子，以及这种抗体分子的用途。 本发明中优选的实施方案是抗体分子，无论是全抗体（例如IgG，如IgG1或IgG4）还是抗体片段（例如scFv，Fab，dAb）。
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公开(公告)号：US10174108B2
公开(公告)日：2019-01-08
申请号：US15278819
申请日：2016-09-28
Applicant: Genzyme Corporation , Optein, Inc.
Inventor： Steven R. Ledbetter , Celia Patricia Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind. Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralize TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
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公开(公告)号：US20170066821A1
公开(公告)日：2017-03-09
申请号：US15278819
申请日：2016-09-28
Applicant: Genzyme Corporation , Optein, Inc.
Inventor： Steven R. Ledbetter , Celia Patricia Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
IPC: C07K16/22
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind. Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
Abstract translation: 本发明涉及抗体分子，特别是结合的抗体分子。 转化生长因子β（TGFβ）及其用途。 更具体地，本发明涉及结合并优选中和TGFβ1，TGFβ2和TGFβ3，所谓的“泛特异性”抗体分子的抗体分子，以及这种抗体分子的用途。 本发明中优选的实施方案是抗体分子，无论是全抗体（例如IgG，如IgG1或IgG4）还是抗体片段（例如scFv，Fab，dAb）。
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Patent Agency Ranking
公开(公告)号：US20230078449A1
公开(公告)日：2023-03-16
申请号：US17932950
申请日：2022-09-16
Applicant: Genzyme Corporation , Optein, Inc.
Inventor： Steven R. Ledbetter , Celia Patricia Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ) and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
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公开(公告)号：US10781252B2
公开(公告)日：2020-09-22
申请号：US16197802
申请日：2018-11-21
Applicant: Genzyme Corporation , Optein, Inc.
Inventor： Steven R. Ledbetter , Celia Patricia Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
IPC: C07K16/22 , A61P13/12 , A61K39/00 , A61K39/395
Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
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公开(公告)号：US20190177406A1
公开(公告)日：2019-06-13
申请号：US16197802
申请日：2018-11-21
Applicant: Genzyme Corporation , Optein, Inc.
Inventor： Steven R. Ledbetter , Celia Patricia Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
IPC: C07K16/22
Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
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公开(公告)号：US20150284456A1
公开(公告)日：2015-10-08
申请号：US14682975
申请日：2015-04-09
Applicant: Genzyme Corporation , Optein, Inc.
Inventor： Steven R. Ledbetter , Celia Patricia Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
IPC: C07K16/22
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
Abstract translation: 本发明涉及结合转化生长因子β（TGFβb）的抗体分子，特别是抗体分子及其应用。 更具体地说，本发明涉及结合并优选中和TGF-β1，TGF-β2和TGFβb3，所谓“泛特异性”抗体分子的抗体分子，以及这种抗体分子的用途。 本发明中优选的实施方案是抗体分子，无论是全抗体（例如IgG，如IgG1或IgG4）还是抗体片段（例如scFv，Fab，dAb）。
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公开(公告)号：US09090685B2
公开(公告)日：2015-07-28
申请号：US14059241
申请日：2013-10-21
Applicant: Genzyme Corporation , Optein, Inc.
Inventor： Steven R. Ledbetter , Celia Patricia Hart , Robert G. Holgate , Lutz U. Jermutus , Catriona L. Buchanan , Alexander R. Duncan , Donna K. Finch
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2317/92
Abstract: The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGFβ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralize TGFβ1, TGFβ2 and TGFβ3, so-called “pan-specific” antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
Abstract translation: 本发明涉及结合转化生长因子β（TGFβb）的抗体分子，特别是抗体分子及其应用。 更具体地说，本发明涉及结合并优选中和TGF-β1，TGF-β2和TGFβb3，所谓“泛特异性”抗体分子的抗体分子，以及这种抗体分子的用途。 本发明中优选的实施方案是抗体分子，无论是全抗体（例如IgG，如IgG1或IgG4）还是抗体片段（例如scFv，Fab，dAb）。
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