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    Pharmaceutical composition for nasal delivery
    1.
    发明授权
    Pharmaceutical composition for nasal delivery 有权

    公开(公告)号：US11883392B2

    公开(公告)日：2024-01-30

    申请号：US17172635

    申请日：2021-02-10

    申请人： Orexo AB

    发明人： Jonas Sävmarker ,  Robert Rönn ,  Andreas Fischer

    IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K31/485

    CPC分类号： A61K31/485 ,  A61K9/0043 ,  A61K9/1652 ,  A61K9/1682

    摘要： According to the invention, there is provided a solid pharmaceutical composition formulation for nasal delivery of an opioid antagonist, comprising a pharmacologically-effective amount of an opioid antagonist and a pharmaceutically-acceptable carrier. The compositions are preferably in the form of a powder produced by spray-drying, which are subsequently loaded into single use nasal applicators. Preferred pharmaceutically-acceptable carriers in this regard include disaccharides (e.g. lactose or trehalose) and dextrins (e.g. cyclodextrins or maltodextrins), preferably spray-dried together in combination. Compositions may further comprise an alkyl saccharide, preferably a sucrose ester, such as sucrose monolaurate. The compositions and applicators may be employed in the treatment of opioid overdose in subjects.

    NEW PHARMACEUTICAL DEVICE FOR USE IN INTRANASAL ADMINISTRATION
    2.
    发明公开
    NEW PHARMACEUTICAL DEVICE FOR USE IN INTRANASAL ADMINISTRATION 审中-公开

    公开(公告)号：US20230310349A1

    公开(公告)日：2023-10-05

    申请号：US18323115

    申请日：2023-05-24

    申请人： OREXO AB

    发明人： Jonas SÄVMARKER ,  Robert RÖNN

    IPC分类号： A61K31/137 ,  A61K47/36 ,  A61K9/00 ,  A61K47/26

    CPC分类号： A61K31/137 ,  A61K47/36 ,  A61K9/0043 ,  A61K9/0075 ,  A61K47/26

    摘要： Disclosed is a needle-free applicator that is suitable for administering a solid, amorphous, mono-particulate powder composition into a body cavity of a human patient, which cavity includes a mucosal surface, wherein the applicator comprises:



    (i) an opaque reservoir comprising said powder composition;
    (ii) an optional actuating means for generating a force upon actuation of the device by a user; and
    (iii)a dispensing means through which, following said actuation, said powder composition may be dispensed,
    wherein said powder composition comprises a pharmacologically-effective dosage amount of an adrenergic receptor modulator, or a pharmaceutically-acceptable salt thereof, encapsulated in an amorphous state along with a pharmaceutically-acceptable carrier material; and
    which powder composition is less than about 4% chemically degraded after storage for:
    (a) at least about 3 months at 40° C. and 75% relative humidity; and/or
    (b) at least about 18 months at below about 30° C.; and/or
    (c) at least about 18 hours at above about 1 million lux of UV light.

    Method of controlling depression in subjects treated for opioid dependence
    3.
    发明授权
    Method of controlling depression in subjects treated for opioid dependence 有权

    公开(公告)号：US11617746B1

    公开(公告)日：2023-04-04

    申请号：US17363877

    申请日：2021-06-30

    申请人： OREXO AB

    发明人： Michael John Sumner

    IPC分类号： A61K31/485 ,  A61P25/36 ,  A61P25/24 ,  A61K9/00

    摘要： The present disclosure is directed to a method of combatting opioid dependence in a subject experiencing a depressive episode. The method comprises treating the subject with an opioid agonist whilst managing their depression or depressive disorder using a step-wise interactive process, particularly where the process involves virtual cognitive behavioral therapy comprising a program for self-treatment. The self-treatment program could be embodied as a mobile medical application.

    Alfentanil composition for the treatment of acute pain
    5.
    发明授权
    Alfentanil composition for the treatment of acute pain 有权
    阿芬太尼组合物用于治疗急性疼痛

    公开(公告)号：US09345698B2

    公开(公告)日：2016-05-24

    申请号：US14331507

    申请日：2014-07-15

    申请人： Orexo AB

    发明人： Anders Pettersson ,  Barbro Johansson ,  Emil Schwan

    IPC分类号： A61K31/454 ,  A61K9/16 ,  A61K9/20 ,  A61K9/00

    CPC分类号： A61K31/454 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/1623 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2077

    摘要： There is provided pharmaceutical compositions for the treatment of pain e.g. short-term pain, which compositions comprise a mixture comprising: (a) microparticles of alfentanil, or a pharmaceutically acceptable salt thereof, which microparticles are presented on the surfaces of larger carrier particles; (b) a water-soluble weak base; and (c) a compound which is a weak acid, which acid is presented in intimate mixture with the microparticles of alfentanil or salt thereof. The composition may further comprise a disintegrant. The acid is preferably citric acid.

    摘要翻译： 提供了用于治疗疼痛的药物组合物。 短期疼痛，所述组合物包含混合物，所述混合物包含：（a）微球呈现在较大载体颗粒表面上的阿芬太尼微粒或其药学上可接受的盐; （b）水溶性弱碱; 和（c）作为弱酸的化合物，该酸与阿芬太尼或其盐的微粒紧密混合存在。 组合物还可以包含崩解剂。 酸优选为柠檬酸。

    ABUSE-RESISTANT PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF OPIOID DEPENDENCE
    6.
    发明申请
    ABUSE-RESISTANT PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF OPIOID DEPENDENCE 有权

    公开(公告)号：US20210008061A1

    公开(公告)日：2021-01-14

    申请号：US17032882

    申请日：2020-09-25

    申请人： Orexo AB

    发明人： Andreas Fischer

    IPC分类号： A61K31/485 ,  A61K9/14 ,  A61K9/20 ,  A61K9/00 ,  A61K31/4748

    摘要： There is provided pharmaceutical compositions for the treatment of e.g. opioid dependency comprising microparticles of a pharmacologically-effective amount of buprenorphine, or a pharmaceutically-acceptable salt thereof, in associative admixture with particles comprising a weak acid, or particles comprising weakly-acidic buffer forming materials. The composition may further comprise a disintegrant and/or particles of a pharmacologically-effective amount of naloxone, or a pharmaceutically-acceptable salt thereof. The compositions are useful in the treatment of opioid dependency/addiction and/or pain.

    NEW ALFENTANIL COMPOSITION FOR THE TREATMENT OF ACUTE PAIN
    7.
    发明申请
    NEW ALFENTANIL COMPOSITION FOR THE TREATMENT OF ACUTE PAIN 审中-公开

    公开(公告)号：US20180214437A1

    公开(公告)日：2018-08-02

    申请号：US15701300

    申请日：2017-09-11

    申请人： Orexo AB

    发明人： Anders Pettersson ,  Barbro Johansson ,  Emil Schwan

    IPC分类号： A61K31/454 ,  A61K9/20 ,  A61K9/00 ,  A61K9/16

    摘要： There is provided pharmaceutical compositions for the treatment of pain e.g. short-term pain, which compositions comprise a mixture comprising: (a) microparticles of alfentanil, or a pharmaceutically acceptable salt thereof, which microparticles are presented on the surfaces of larger carrier particles; (b) a water-soluble weak base; and (c) a compound which is a weak acid, which acid is presented in intimate mixture with the microparticles of alfentanil or salt thereof. The composition may further comprise a disintegrant. The acid is preferably citric acid.

    ABUSE-RESISTANT PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF OPIOID DEPENDENCE
    9.
    发明申请
    ABUSE-RESISTANT PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF OPIOID DEPENDENCE 有权
    用于治疗依从性的抗药物药物组合物

    公开(公告)号：US20150297583A1

    公开(公告)日：2015-10-22

    申请号：US14577823

    申请日：2014-12-19

    申请人： Orexo AB

    发明人： Andreas Fischer

    IPC分类号： A61K31/4748 ,  A61K9/20 ,  A61K31/485

    CPC分类号： A61K31/485 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/14 ,  A61K9/20 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/2095 ,  A61K31/4748

    摘要： There is provided pharmaceutical compositions for the treatment of e.g. opioid dependency comprising microparticles of a pharmacologically-effective amount of buprenorphine, or a pharmaceutically-acceptable salt thereof, in associative admixture with particles comprising a weak acid, or particles comprising weakly-acidic buffer forming materials. The composition may further comprise a disintegrant and/or particles of a pharmacologically-effective amount of naloxone, or a pharmaceutically-acceptable salt thereof. The compositions are useful in the treatment of opioid dependency/addiction and/or pain.

    摘要翻译： 提供了用于治疗例如药物的药物组合物。 包含药理学有效量的丁丙诺啡或其药学上可接受的盐的微粒与包含弱酸的微粒或包含弱酸性缓冲液形成材料的颗粒的缔合混合物中的阿片样物质依赖性。 组合物还可以包含崩解剂和/或药理学有效量的纳洛酮或其药学上可接受的盐的颗粒。 该组合物可用于治疗阿片依赖性/成瘾和/或疼痛。