公开(公告)号：US4983385A

公开(公告)日：1991-01-08

申请号：US250543

申请日：1988-09-29

申请人： Kenji Hasegawa ,  Nakashima Nakashima ,  Toru Eguchi ,  Ota Masako

发明人： Kenji Hasegawa ,  Nakashima Nakashima ,  Toru Eguchi ,  Ota Masako

IPC分类号： A61K9/06 ,  A61K9/00 ,  A61K47/00 ,  A61K47/32

CPC分类号： A61K9/006 ,  Y10S514/944 ,  Y10S514/969

摘要： An ointment base which comprises:(a) a hydrogel formed by a water-soluble polymer and a material selected from the group consisting of water, a polyhydric alcohol and a mixture thereof;(b) a methacrylate copolymer selected from a group consisting of dimethylaminoethyl methacrylate/methyl methacrylate copolymer, ethyl methacrylate/chlorotrimethylammonium ethyl methacrylate copolymer or a mixture thereof; and(c) a solubilizer which dissolves the methacrylate copolymer but is incompatible with water and the polyhydric alcohol,a weight ratio of the methacrylate copolymer to the solubilizer being 1:2-1:25.

摘要翻译： 一种软膏基质，其包含：（a）由水溶性聚合物形成的水凝胶和选自水，多元醇及其混合物的材料; （b）甲基丙烯酸酯共聚物，其选自甲基丙烯酸二甲基氨基乙酯/甲基丙烯酸甲酯共​​聚物，甲基丙烯酸乙酯/氯代三甲基铵甲基丙烯酸乙酯共聚物或其混合物; 和（c）溶解甲基丙烯酸酯共聚物但与水和多元醇不相容的增溶剂，甲基丙烯酸酯共聚物与增溶剂的重量比为1:2-1:25。