公开(公告)号：US08710008B2

公开(公告)日：2014-04-29

申请号：US13141465

申请日：2009-12-22

申请人： Oyvind Jacobsen ,  Jo Klaveness ,  Pal Rongved ,  Mahmood Amiry-Moghaddam ,  Ole Petter Ottersen

发明人： Oyvind Jacobsen ,  Jo Klaveness ,  Pal Rongved ,  Mahmood Amiry-Moghaddam ,  Ole Petter Ottersen

IPC分类号： A61K38/00 ,  C07K14/00 ,  A61P25/00 ,  A61K38/16 ,  C07K14/705

CPC分类号： A61K38/00 ,  A61K38/16 ,  C07K14/00 ,  C07K14/705

摘要： A peptide comprising a unit of formula (I) and having a molecular weight of less than 2000 wherein each X is independently an organic group, e.g. a C1-6 alkyl or C1-6 alkenyl group, preferably —CH2—CH═CH2, or the two X groups taken together can form a covalent or non-covalent link between the two O groups, preferably a C1-10 saturated or unsaturated carbon chain optionally interrupted by one or more heteroatoms selected from O, S, N, P, or Si, especially a C3-10 carbon chain or one X represents an azido group and the other an C2-6-alkynyl group; both Z's are the same and are O or S; each Y is independently C, CH, CH2, N or NH; R1 is H or C1-6 alkyl; R2 is H or C1-6 alkyl; R5 is a C1-6 alkyl group, preferably isopropyl; or a salt, ester or prodrug thereof.

摘要翻译： 一种包含式（I）单元并且分子量小于2000的肽，其中每个X独立地是有机基团，例如， C 1-6烷基或C 1-6烯基，优选-CH 2 -CH 2 CH 2或两个X基团可以在两个O基之间形成共价或非共价键，优选为C1-10饱和或不饱和的 碳链，任选地被一个或多个选自O，S，N，P或Si的杂原子中断，特别是C3-10碳链或一个X代表叠氮基，另一个是C 2-6炔基; 两个Z都是相同的，是O或S; 每个Y独立地为C，CH，CH 2，N或NH; R1是H或C1-6烷基; R2是H或C1-6烷基; R5是C1-6烷基，优选是异丙基; 或其盐，酯或前药。

公开(公告)号：US20120245094A1

公开(公告)日：2012-09-27

申请号：US13141465

申请日：2008-12-22

申请人： Oyvind Jacobsen ,  Jo Klaveness ,  Pal Rongved ,  Mahmood Amiry-Moghaddam ,  Ole Petter Ottersen

发明人： Oyvind Jacobsen ,  Jo Klaveness ,  Pal Rongved ,  Mahmood Amiry-Moghaddam ,  Ole Petter Ottersen

IPC分类号： C07K7/06 ,  A61P25/00 ,  A61K38/08

CPC分类号： A61K38/00 ,  A61K38/16 ,  C07K14/00 ,  C07K14/705

摘要： A peptide comprising a unit of formula (I) and having a molecular weight of less than 2000 wherein each X is independently an organic group, e.g. a C1-6 alkyl or C1-6 alkenyl group, preferably —CH2—CH═CH2, or the two X groups taken together can form a covalent or non-covalent link between the two O groups, preferably a C1-10 saturated or unsaturated carbon chain optionally interrupted by one or more heteroatoms selected from O, S, N, P, or Si, especially a C3-10 carbon chain or one X represents an azido group and the other an C2-6-alkynyl group; both Z's are the same and are O or S; each Y is independently C, CH, CH2, N or NH; R1 is H or C1-6 alkyl; R2 is H or C1-6 alkyl; R5 is a C1-6 alkyl group, preferably isopropyl; or a salt, ester or prodrug thereof.

摘要翻译： 一种包含式（I）单元并且分子量小于2000的肽，其中每个X独立地是有机基团，例如， C 1-6烷基或C 1-6烯基，优选-CH 2 -CH 2 CH 2或两个X基团可以在两个O基之间形成共价或非共价键，优选为C1-10饱和或不饱和的 碳链，任选地被一个或多个选自O，S，N，P或Si的杂原子中断，特别是C3-10碳链或一个X代表叠氮基，另一个是C 2-6炔基; 两个Z都是相同的，是O或S; 每个Y独立地为C，CH，CH 2，N或NH; R1是H或C1-6烷基; R2是H或C1-6烷基; R5是C1-6烷基，优选是异丙基; 或其盐，酯或前药。