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    HBV treatment
    2.
    发明授权
    HBV treatment 有权
    HBV治疗

    公开(公告)号：US09080174B2

    公开(公告)日：2015-07-14

    申请号：US13882124

    申请日：2011-10-27

    申请人： Michael Wayne Graham ,  Peter French ,  York YuanYuan Zhu ,  Yixiang Lu ,  TieJun Li ,  Yuncheng Sun ,  XiaoJun Tang ,  Li Shan

    发明人： Michael Wayne Graham ,  Peter French ,  York YuanYuan Zhu ,  Yixiang Lu ,  TieJun Li ,  Yuncheng Sun ,  XiaoJun Tang ,  Li Shan

    IPC分类号： C07H21/04 ,  C12N15/113

    CPC分类号： C12N15/1131 ,  C12N2310/14 ,  C12N2310/531

    摘要： RNA interference (RNAi) agents and the use of the RNAi agents for treating hepatitis B infection in individuals, as well as pharmaceutical compositions containing the RNAi agents are provided. The RNAi agents, or constructs for expressing them are utilized to inhibit expression of at least one Hepatitis B virus (HBV) gene, wherein each agent comprises an effector sequence complementary to or substantially complementary to a predicted sequence transcribed from a target region. In some embodiments of the present invention, the agents have more than one effector sequence; wherein the multiple effectors may target the same region of an HBV gene, different (possibly overlapping) regions of the same gene and/or different HBV genes.

    摘要翻译： 提供RNA干扰（RNAi）试剂和使用RNAi试剂治疗个体中的乙型肝炎感染，以及含有RNAi试剂的药物组合物。 用于表达它们的RNAi剂或构建体用于抑制至少一种乙型肝炎病毒（HBV）基因的表达，其中每种试剂包含与从靶区转录的预测序列互补或基本上互补的效应序列。 在本发明的一些实施方案中，所述试剂具有多于一个效应序列; 其中所述多个效应子可以靶向相同基因和/或不同HBV基因的HBV基因的相同区域，不同（可能重叠的）区域。

    Apparatus and method for processing bovine pericardium
    3.
    发明授权
    Apparatus and method for processing bovine pericardium 有权
    用于处理牛心包膜的装置和方法

    公开(公告)号：US07651387B2

    公开(公告)日：2010-01-26

    申请号：US12078328

    申请日：2008-03-28

    申请人： Peter French Meyer ,  Brian Geoffery Bennett

    发明人： Peter French Meyer ,  Brian Geoffery Bennett

    IPC分类号： A22C17/16

    CPC分类号： A61L27/3604 ,  A61L27/3691 ,  A61L2430/40

    摘要： An apparatus for use in processing “raw” pericardium. The apparatus includes a mold having a generally hemispheroid dome and a support base upon which the mold is mounted. The hemispheroid dome has a diameter suitable for stretching a pericardium over the dome. Also, a method for processing “raw” pericardium. The method involves stretching raw pericardium over a mold such that the pericardium conforms to the shape of the mold and the mold stretches the pericardium. This is followed by separating at least some of the fat layer off the pericardial tissue layer where the pericardium is mounted over the mold and finally removing fat from the total pericardium surface.

    摘要翻译： 用于处理“原始”心包的装置。 该装置包括具有大致半球形圆顶的模具和安装模具的支撑基座。 半球形圆顶具有适于在圆顶上拉伸心包的直径。 另外，一种处理“原始”心包膜的方法。 该方法涉及在模具上拉伸原始心包，使得心包与模具的形状一致，并且模具延伸心包。 然后将至少一些脂肪层从心包组织层离开，心包被安装在模具上，最后从总心包表面除去脂肪。

    Apparatus and method for processing bovine pericardium
    5.
    发明申请
    Apparatus and method for processing bovine pericardium 有权
    用于处理牛心包膜的装置和方法

    公开(公告)号：US20090247061A1

    公开(公告)日：2009-10-01

    申请号：US12078328

    申请日：2008-03-28

    申请人： Peter French Meyer ,  Brian Geoffery Bennett

    发明人： Peter French Meyer ,  Brian Geoffery Bennett

    IPC分类号： A22C17/00

    CPC分类号： A61L27/3604 ,  A61L27/3691 ,  A61L2430/40

    摘要： An apparatus for use in processing “raw” pericardium. The apparatus includes a mold having a generally hemispheroid dome and a support base upon which the mold is mounted. The hemispheroid dome has a diameter suitable for stretching a pericardium over the dome. Also, a method for processing “raw” pericardium. The method involves stretching raw pericardium over a mold such that the pericardium conforms to the shape of the mold and the mold stretches the pericardium. This is followed by separating at least some of the fat layer off the pericardial tissue layer where the pericardium is mounted over the mold and finally removing fat from the total pericardium surface.

    摘要翻译： 用于处理“原始”心包的装置。 该装置包括具有大致半球形圆顶的模具和安装模具的支撑基座。 半球形圆顶具有适于在圆顶上拉伸心包的直径。 另外，一种处理“原始”心包膜的方法。 该方法涉及在模具上拉伸原始心包，使得心包与模具的形状一致，并且模具延伸心包。 然后将至少一些脂肪层从心包组织层离开，心包被安装在模具上，最后从总心包表面除去脂肪。