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    Malignant and non-malignant disease treatment with Ras antagonists
    1.
    发明授权
    Malignant and non-malignant disease treatment with Ras antagonists 有权
    恶性和非恶性疾病治疗与Ras拮抗剂

    公开(公告)号：US09309203B2

    公开(公告)日：2016-04-12

    申请号：US14350303

    申请日：2012-10-05

    申请人： PISCES THERAPEUTICS, LLC

    发明人： James H. Wikel ,  Michael J. Brownstein

    IPC分类号： C07D233/20 ,  A61K31/41 ,  C07D239/06 ,  C07D257/04 ,  C07D285/06 ,  C07D333/38 ,  C07D333/40

    CPC分类号： C07D239/06 ,  C07D233/20 ,  C07D257/04 ,  C07D285/06 ,  C07D333/38 ,  C07D333/40

    摘要： The present disclosure describes new inhibitors or antagonists of Ras useful for the treatment of conditions resulting from Ras-induced or mediated cellular processes, including cellular proliferation, differentiation, apoptosis, senescence, and survival. These cellular processes may be associated with a non-malignant or malignant disease, disorder, or pathological condition. The present disclosure also describes a method for inhibiting such Ras-induced or mediated cellular processes. The method entails administering a Ras antagonist in an amount effective to inhibit such cellular processes.

    摘要翻译： 本公开描述了用于治疗由Ras诱导或介导的细胞过程（包括细胞增殖，分化，凋亡，衰老和存活）引起的病症的新的抑制剂或拮抗剂。 这些细胞过程可能与非恶性或恶性疾病，病症或病理状况相关。 本公开还描述了抑制这种Ras诱导或介导的细胞过程的方法。 该方法需要以有效抑制这种细胞过程的量施用Ras拮抗剂。

    MALIGNANT AND NON-MALIGNANT DISEASE TREATMENT WITH RAS ANTAGONISTS
    2.
    发明申请
    MALIGNANT AND NON-MALIGNANT DISEASE TREATMENT WITH RAS ANTAGONISTS 有权
    恶性和非恶性疾病治疗与RAS ANTAGONISTS

    公开(公告)号：US20160207891A1

    公开(公告)日：2016-07-21

    申请号：US15080995

    申请日：2016-03-25

    申请人： PISCES THERAPEUTICS, LLC

    发明人： James H. Wikel ,  Michael J. Brownstein

    IPC分类号： C07D257/04 ,  C07D239/06 ,  C07D233/20

    CPC分类号： C07D257/04 ,  A61K31/41 ,  C07D233/20 ,  C07D239/06 ,  C07D285/06

    摘要： The present disclosure describes new inhibitors or antagonists of Ras useful for the treatment of conditions resulting from Ras-induced or mediated cellular processes, including cellular proliferation, differentiation, apoptosis, senescence, and survival. These cellular processes may be associated with a non-malignant or malignant disease, disorder, or pathological condition. The present disclosure also describes a method for inhibiting such Ras-induced or mediated cellular processes. The method entails administering a Ras antagonist in an amount effective to inhibit such cellular processes.

    摘要翻译： 本公开描述了用于治疗由Ras诱导或介导的细胞过程（包括细胞增殖，分化，凋亡，衰老和存活）引起的病症的新的抑制剂或拮抗剂。 这些细胞过程可能与非恶性或恶性疾病，病症或病理状况相关。 本公开还描述了抑制这种Ras诱导或介导的细胞过程的方法。 该方法需要以有效抑制这种细胞过程的量施用Ras拮抗剂。