公开(公告)号：US20220110943A1

公开(公告)日：2022-04-14

申请号：US17267693

申请日：2019-08-09

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  IRBM S.P.A. ,  PROMIDIS S.R.L. ,  ISTITUTO NAZIONALE Dl GENETICA MOLECOLARE - INGM

Inventor： Raffaele DE FRANCESCO ,  Lorena DONNICI ,  Luca GUIDOTTI ,  Matteo IANNACONE ,  Romano DI FABIO ,  Vincenzo SUMMA ,  Adolfo PRANDI ,  Pietro RANDAZZO ,  Davide GORNATI ,  Alessandro GRILLO ,  Luca FERRANTE ,  Leda Ivanova BENCHEVA ,  Marilenia DE MATTEO ,  Marco FERRARA

IPC: A61K31/554 ,  C07D515/14 ,  C07D515/08 ,  A61K31/407 ,  C07D519/00 ,  C07D513/14 ,  A61P31/20

Abstract: The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing the compounds.

公开(公告)号：US20210276967A1

公开(公告)日：2021-09-09

申请号：US17261223

申请日：2019-07-19

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  IRBM S.P.A. ,  PROMIDIS S.R.L. ,  ISTITUTO NAZIONALE DI GENETICA MOLECOLARE - INGM

Inventor： Raffaele DE FRANCESCO ,  Adolfo PRANDI ,  Pietro RANDAZZO ,  Lorena DONNICI ,  Luca GUIDOTTI ,  Matteo IANNACONE ,  Romano DI FABIO ,  Vincenzo SUMMA ,  Leda Ivanova BENCHEVA ,  Marilenia DE MATTEO ,  Luca FERRANTE

IPC: C07D305/08 ,  A61K45/06 ,  C07D207/48 ,  C07D213/42 ,  C07D205/04 ,  C07D213/73 ,  C07D211/96 ,  C07C311/16

Abstract: The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing said compounds.