公开(公告)号：US20250008960A1

公开(公告)日：2025-01-09

申请号：US18802256

申请日：2024-08-13

Applicant: CORTEVA AGRISCIENCE LLC

Inventor： RONALD J. HEEMSTRA ,  RONALD ROSS, JR. ,  KYLE A. DEKORVER ,  KAITLYN GRAY ,  DANIEL I. KNUEPPEL ,  PETER VEDNOR ,  TIMOTHY P. MARTIN ,  JOSEPH D. ECKELBARGER ,  JOHN F. DAEUBLE, SR. ,  RICKY HUNTER ,  DAVID A. DEMETER ,  TONY K. TRULLINGER ,  ERICH W. BAUM ,  ZOLTAN L. BENKO ,  NAKYEN CHOY ,  GARY D. CROUSE ,  FANGZHENG LI ,  JEFFREY NISSEN ,  MONICA B. OLSON ,  MICHELLE RIENER ,  THOMAS C. SPARKS ,  FRANK J. WESSELS ,  MAURICE C. YAP

IPC: A01N53/00 ,  A01N37/22 ,  A01N37/34 ,  A01N41/10 ,  A01N43/40 ,  A01N43/60 ,  A01N43/653 ,  A01N43/707 ,  A01N43/82 ,  A01N43/90 ,  C07C233/63 ,  C07C233/65 ,  C07C237/22 ,  C07C237/42 ,  C07C255/29 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07C271/28 ,  C07C271/66 ,  C07C311/08 ,  C07C311/46 ,  C07C317/14 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07D205/04 ,  C07D207/10 ,  C07D207/273 ,  C07D207/452 ,  C07D209/49 ,  C07D213/56 ,  C07D213/75 ,  C07D213/81 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07D215/38 ,  C07D231/12 ,  C07D231/56 ,  C07D233/36 ,  C07D233/80 ,  C07D235/30 ,  C07D241/20 ,  C07D249/08 ,  C07D253/07 ,  C07D261/12 ,  C07D263/26 ,  C07D277/30 ,  C07D277/36 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07D307/33 ,  C07D307/52 ,  C07D309/14 ,  C07D331/04 ,  C07D333/36 ,  C07D333/48 ,  C07D333/60 ,  C07D487/04

Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US12151999B2

公开(公告)日：2024-11-26

申请号：US18606722

申请日：2024-03-15

Applicant: Hangzhou PhecdaMed Co., Ltd.

Inventor： Hongguang Xia ,  Mengyang Fan ,  Xufeng Cen ,  Xiaoyan Xu ,  Ronghai Wu ,  Dong Liu ,  Zhen Tian

IPC: C07C311/21 ,  A61K31/18 ,  A61K31/337 ,  A61K31/381 ,  A61K31/402 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/433 ,  A61K31/44 ,  C07D207/06 ,  C07D231/18 ,  C07D249/04 ,  C07D249/12 ,  C07D257/04 ,  C07D261/10 ,  C07D285/06 ,  C07D305/08 ,  C07D333/34 ,  C07D333/62

Abstract: The present application discloses small molecule compounds having a naphthylamine structure and an application thereof. In the present application, the structure of a compound having a structure as shown in general formula (I) is as shown in the drawing. The compound and the pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof that are provided by the present application or the pharmaceutical composition provided by the present application can selectively induce autophagy in damaged mitochondria without affecting or only weakly affecting normal mitochondria, and further have superior metabolic stability and pharmacokinetic properties, lower toxicity, and better druggability.

公开(公告)号：US20240360075A1

公开(公告)日：2024-10-31

申请号：US18640931

申请日：2024-04-19

Applicant: ALCON INC.

Inventor： Heeren M. Gordhan ,  Mitchell A. deLong ,  Jill M. Sturdivant ,  David Archer Ellis ,  Cynthia L. Lichorowic

IPC: C07C233/60 ,  A61K9/00 ,  A61K31/16 ,  A61K31/165 ,  A61K31/167 ,  A61K31/175 ,  A61K31/192 ,  A61K31/27 ,  A61K31/277 ,  A61K31/337 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/382 ,  A61K31/397 ,  A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/4465 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/69 ,  A61K47/12 ,  A61K47/18 ,  A61K47/38 ,  C07C231/02 ,  C07C233/58 ,  C07C233/59 ,  C07C233/62 ,  C07C233/63 ,  C07C235/14 ,  C07C235/56 ,  C07C237/24 ,  C07C271/20 ,  C07C271/24 ,  C07C279/22 ,  C07C315/04 ,  C07C317/30 ,  C07D205/04 ,  C07D207/09 ,  C07D209/54 ,  C07D211/58 ,  C07D213/75 ,  C07D213/79 ,  C07D231/40 ,  C07D239/42 ,  C07D263/04 ,  C07D263/56 ,  C07D265/36 ,  C07D275/03 ,  C07D277/46 ,  C07D295/088 ,  C07D295/135 ,  C07D295/32 ,  C07D305/06 ,  C07D305/08 ,  C07D305/14 ,  C07D307/22 ,  C07D307/94 ,  C07D309/14 ,  C07D311/58 ,  C07D335/02 ,  C07F5/02

CPC classification number: C07C233/60 ,  A61K9/0048 ,  A61K31/16 ,  A61K31/165 ,  A61K31/167 ,  A61K31/175 ,  A61K31/192 ,  A61K31/27 ,  A61K31/277 ,  A61K31/337 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/382 ,  A61K31/397 ,  A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/4465 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/69 ,  A61K47/12 ,  A61K47/183 ,  A61K47/186 ,  A61K47/38 ,  C07C231/02 ,  C07C233/58 ,  C07C233/59 ,  C07C233/62 ,  C07C233/63 ,  C07C235/14 ,  C07C235/56 ,  C07C237/24 ,  C07C271/20 ,  C07C271/24 ,  C07C279/22 ,  C07C315/04 ,  C07C317/30 ,  C07D205/04 ,  C07D207/09 ,  C07D209/54 ,  C07D211/58 ,  C07D213/75 ,  C07D213/79 ,  C07D231/40 ,  C07D239/42 ,  C07D263/04 ,  C07D263/56 ,  C07D265/36 ,  C07D275/03 ,  C07D277/46 ,  C07D295/088 ,  C07D295/135 ,  C07D295/32 ,  C07D305/06 ,  C07D305/08 ,  C07D305/14 ,  C07D307/22 ,  C07D307/94 ,  C07D309/14 ,  C07D311/58 ,  C07D335/02 ,  C07F5/025 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/18 ,  C07C2602/38 ,  C07C2602/42 ,  C07C2602/50

Abstract: Described herein are modified monoterpene TRPM8 activating compounds. In particular, provided herein are compounds that affect the function of ion channels in a cell, and are useful as therapeutic agents or with therapeutic agents. The compounds provided herein are useful in the treatment of a variety of diseases and conditions including inflammatory eye diseases such as uveitis, cardiovascular diseases, inflammatory diseases, and diseases characterized by abnormal growth, such as cancers.

公开(公告)号：US20240245691A1

公开(公告)日：2024-07-25

申请号：US18557183

申请日：2022-04-26

Applicant: Sitryx Therapeutics Limited

Inventor： Matthew Colin Thor FYFE ,  Michael Liam COOKE ,  David COUSIN ,  Saleh AHMED ,  Alessandro MAZZACANI

IPC: A61K31/5375 ,  A61K31/18 ,  A61K31/192 ,  A61K31/337 ,  A61K31/38 ,  A61K31/41 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/445 ,  A61K45/06 ,  A61P29/00 ,  C07C233/13 ,  C07C233/14 ,  C07C311/04 ,  C07D211/46 ,  C07D211/96 ,  C07D213/26 ,  C07D257/04 ,  C07D295/088 ,  C07D305/08 ,  C07D401/12 ,  C07D409/12

CPC classification number: A61K31/5375 ,  A61K31/18 ,  A61K31/192 ,  A61K31/337 ,  A61K31/38 ,  A61K31/41 ,  A61K31/4418 ,  A61K31/444 ,  A61K31/445 ,  A61K45/06 ,  A61P29/00 ,  C07C233/13 ,  C07C233/14 ,  C07C311/04 ,  C07D211/46 ,  C07D211/96 ,  C07D213/26 ,  C07D257/04 ,  C07D295/088 ,  C07D305/08 ,  C07D401/12 ,  C07D409/12

Abstract: The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response:






wherein RA, RZ, RC, RD, RF and RG are as defined herein.

公开(公告)号：US11814360B2

公开(公告)日：2023-11-14

申请号：US16753591

申请日：2018-10-04

Applicant: Novomer, Inc.

Inventor： Oleg Kulikov ,  Sadesh H. Sookraj ,  Utpal Mahendra Vakil ,  Matthew Goodrich

IPC: C07D305/12 ,  C07D305/08 ,  C07D305/14 ,  C07D307/20 ,  C07D407/12 ,  C08G18/09 ,  C08L75/04 ,  C07C263/12 ,  C08G18/44 ,  C08G18/48 ,  C07C263/00 ,  C07C265/00

CPC classification number: C07D305/12 ,  C07C263/00 ,  C07C263/12 ,  C07C265/00 ,  C07D305/08 ,  C07D305/14 ,  C07D307/20 ,  C07D407/12 ,  C08G18/09 ,  C08G18/44 ,  C08G18/48 ,  C08L75/04

Abstract: The present invention is directed to processes for producing isocyanates and isocyanate derivatives from epoxide and carbon monoxide reagents. In preferred embodiments, the processes include a step for providing carbonylation of an epoxide reagent with a carbon monoxide reagent to produce a beta-lactone intermediate. In certain preferred embodiments, further carbonylation of a beta-lactone intermediate produces a succinic anhydride intermediate. The processes of the present invention include steps for rearranging beta-lactone intermediates and/or succinic anhydride intermediates to produce isocyanate products and/or isocyanate derivatives. In certain preferred embodiments, the isocyanate products may be copolymerized with polyol oligomers to provide polyurethane products.

公开(公告)号：US20220289673A1

公开(公告)日：2022-09-15

申请号：US17631114

申请日：2020-07-29

Applicant: Vanderbilt University

Inventor： William P. Tansey ,  Stephen W. Fesik ,  Shaun R. Stauffer ,  Alex G. Waterson ,  Changho Han ,  Joseph R. Alvarado ,  Jonathan D. MacDonald ,  Selena Chacon Simon ,  Sameer S. Nikhar ,  Alexey Kuznetsov

IPC: C07C311/21 ,  C07C311/29 ,  C07C311/39 ,  C07C311/43 ,  C07C317/34 ,  C07C317/38 ,  C07C317/48 ,  C07C323/49 ,  C07C381/00 ,  C07D205/04 ,  C07D207/08 ,  C07D207/12 ,  C07D211/48 ,  C07D207/27 ,  C07D213/40 ,  C07D213/56 ,  C07D213/64 ,  C07D215/36 ,  C07D233/36 ,  C07D239/26 ,  C07D249/14 ,  C07D265/30 ,  C07D241/04 ,  C07D305/08 ,  C07D307/14 ,  C07D307/18 ,  C07D307/22 ,  C07D307/52 ,  C07D307/79 ,  C07D309/04 ,  C07D309/10 ,  C07D309/14 ,  C07D309/22 ,  C07D333/20 ,  C07D333/24

Abstract: Substituted N-phenyl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

公开(公告)号：US11420935B2

公开(公告)日：2022-08-23

申请号：US16849728

申请日：2020-04-15

Applicant: Vivace Therapeutics, Inc.

Inventor： Andrei W. Konradi ,  Tracy Tzu-Ling Tang Lin

IPC: C07C235/66 ,  C07C311/51 ,  C07D217/24 ,  C07D217/26 ,  C07D401/12 ,  C07D213/40 ,  C07C255/24 ,  C07D333/70 ,  C07D305/08 ,  C07D305/06 ,  C07D241/12 ,  C07D233/64 ,  C07D257/04 ,  C07D213/73 ,  C07D213/61

Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating deseases, such as cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

公开(公告)号：US20220194912A1

公开(公告)日：2022-06-23

申请号：US17560026

申请日：2021-12-22

Applicant: Momentive Performance Materials Inc.

Inventor： Xu QIN ,  Benjamin FALK ,  Mana TAMAMI ,  Yuriy GALABURA ,  Amar PAWAR ,  Roland WAGNER

IPC: C07D303/04 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q19/00 ,  A61Q17/04 ,  C07C55/02 ,  C07D305/08 ,  C07C211/09 ,  C07C59/01 ,  C07C31/20 ,  A61K8/86 ,  C08G59/32 ,  C08G59/42 ,  C08G59/50 ,  C08G59/62

Abstract: The present disclosure relates to gel compositions comprising the reaction product of at least one epoxidized molecule and at least one crosslinker, which has the benefit of compatibility with personal care components and the resulting personal care formulations. The present disclosure also relates to methods of preparing gel compositions.

公开(公告)号：US20220055985A1

公开(公告)日：2022-02-24

申请号：US17463011

申请日：2021-08-31

Applicant: The Liver Company Inc.

Inventor： Julie FARAND ,  Joshua A. KAPLAN ,  Gregory NOTTE ,  Casey Lockwood OLEN ,  Michael SANGI ,  David SPERANDIO

IPC: C07C323/25 ,  C07C323/30 ,  C07C323/31 ,  C07D205/04 ,  C07D207/48 ,  C07D213/89 ,  C07D231/18 ,  C07D235/00 ,  C07D239/26 ,  C07D257/04 ,  C07D275/02 ,  C07D277/36 ,  C07D295/116 ,  C07D305/08 ,  C07D309/08 ,  C07D335/02 ,  C07D451/02 ,  C07D493/08 ,  C07F9/50 ,  C07C313/06 ,  A61K31/18 ,  C07C311/08 ,  C07C311/21 ,  C07C311/39 ,  C07C311/29 ,  C07C311/46 ,  C07C311/14 ,  C07C311/13

Abstract: Provided is a compound of Formula (I): wherein the variable groups are defined herein.

公开(公告)号：US20210214323A1

公开(公告)日：2021-07-15

申请号：US17187061

申请日：2021-02-26

Applicant: FORMA Therapeutics, Inc.

Inventor： Kenneth W. Bair ,  David R. Lancia, JR. ,  Hongbin LI ,  James Loch ,  Wei Lu ,  Matthew W. Martin ,  David S. Millan ,  Shawn E.R. Schiller ,  Mark J. Tebbe

IPC: C07D295/192 ,  A61K45/06 ,  C07D215/14 ,  C07D231/56 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D257/04 ,  C07D487/04 ,  C07D263/57 ,  C07D491/048 ,  C07D271/12 ,  C07D495/04 ,  C07D209/18 ,  C07D277/62 ,  C07D277/66 ,  C07D513/04 ,  C07D213/56 ,  C07D305/08 ,  A61K31/4965 ,  A61P35/00 ,  A61K31/495 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/5025 ,  A61K31/506 ,  C07D209/08 ,  C07D213/65 ,  C07D213/69 ,  C07D217/16 ,  C07D231/12 ,  C07D235/08 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04

Abstract: The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below: