公开(公告)号：US06207195B1

公开(公告)日：2001-03-27

申请号：US09095882

申请日：1998-06-11

申请人： Scott Walsh ,  Ronald Rubenstein ,  Pam Zeitlin ,  Kam W. Leong

发明人： Scott Walsh ,  Ronald Rubenstein ,  Pam Zeitlin ,  Kam W. Leong

IPC分类号： C12N1500

CPC分类号： A61K9/5169 ,  A61K31/192 ,  A61K45/06 ,  A61K47/62 ,  A61K47/6435 ,  A61K47/6929 ,  A61K48/00 ,  B82Y5/00 ,  Y10S977/884 ,  Y10S977/906 ,  Y10S977/915 ,  Y10S977/92 ,  Y10S977/923

摘要： 4-Phenylbutyrate exerts many beneficial biological effects. It appears to induce the transcription of certain promoters, as well as having a remedial effect on proteins which are aberrantly localized within the cell. In addition, it appears to cause cells to developmentally differentiate. The present invention provides nanosphere formulations of 4-phenylbutyrate and other drugs which remediate defective protein localization intracellularly. These formulations permit lower concentrations of drugs to be administered, providing both cost and safety benefits.

摘要翻译： 4-苯基丁酸酯具有许多有益的生物学效应。 似乎诱导某些启动子的转录，以及对细胞内异常定位的蛋白质具有补救作用。 此外，它似乎导致细胞发育分化。 本发明提供4-苯基丁酸酯和其它药物的纳米球配方，其可以修复细胞内的缺陷蛋白质定位。 这些制剂允许施用较低浓度的药物，既提供成本和安全性益处。