公开(公告)号：US20090214605A1

公开(公告)日：2009-08-27

申请号：US11887857

申请日：2006-04-05

Applicant: Jean-Christophe Leroux ,  Marie-Christine Jones ,  Pankaj Kumar Tewari

Inventor： Jean-Christophe Leroux ,  Marie-Christine Jones ,  Pankaj Kumar Tewari

IPC: A61K8/02 ,  A61K9/00 ,  A61K47/30 ,  A61K47/32 ,  A61K38/16 ,  A61K38/02 ,  A61K39/395 ,  A61K31/7052 ,  A61K31/715 ,  A61P43/00 ,  A61Q90/00

CPC classification number: C08F220/32 ,  A61K9/1075 ,  A61K9/5146 ,  A61K49/0082 ,  A61K49/0093

Abstract: The present invention describes the preparation of reverse polymeric micelles (RPM) through hydrophobically-modified star-shaped polyols. More specifically, RPM are obtained from polymeric structures where the polyol constitutes the hydrophilic domain while the hydrophobic shell is obtained either through the modification of existing chemical functions (e.g. esterification) or through copolymerization with hydrocarbon (alkyl)acrylate derivatives. Hydrophilic guests can be accommodated in the micelle core opening new avenues for the use of such carriers as delivery agents for polar active compounds.

Abstract translation: 本发明描述了通过疏水改性的星形多元醇制备反向聚合胶束（RPM）。 更具体地，RPM是从聚合物结构获得的，其中多元醇构成亲水结构域，而通过改变现有化学功能（例如酯化）或通过与烃（烷基）丙烯酸酯衍生物的共聚获得疏水壳。 亲水性客人可以容纳在胶束芯中，用于使用这种载体作为极性活性化合物的递送剂的新途径。