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    Phenyl substituted maleimides as medicaments for blocking degenerative tissue damages by inhibiting MPT
    1.
    发明授权
    Phenyl substituted maleimides as medicaments for blocking degenerative tissue damages by inhibiting MPT 有权
    苯基取代的马来酰亚胺作为通过抑制MPT阻断退行性组织损伤的药物

    公开(公告)号：US07915304B2

    公开(公告)日：2011-03-29

    申请号：US12444407

    申请日：2007-09-21

    申请人： PierGiuseppe Pellicci ,  Marco Giorgio ,  Saverio Minucci ,  Paolo Bernardi ,  Gilles Pain ,  Stephen Martin Courtney ,  Christopher John Yarnold ,  Joachim Kraemer

    发明人： PierGiuseppe Pellicci ,  Marco Giorgio ,  Saverio Minucci ,  Paolo Bernardi ,  Gilles Pain ,  Stephen Martin Courtney ,  Christopher John Yarnold ,  Joachim Kraemer

    IPC分类号： A01N43/36 ,  A61K31/40

    CPC分类号： A61K31/4025 ,  C07D207/444 ,  C07D207/448 ,  C07D207/452 ,  Y10S514/866

    摘要： The invention discloses the use of a compound of formula (I), wherein R1, R2, R3, and R4 each independently represents: hydrogen; halo; hydroxy; (C1-C6) alkyl optionally substituted by hydroxy or (C1-C4) alkoxy; (C1-C6) haloalkyl; (C1-C6) alkoxy; and (C1-C6) haloalkoxy; for the preparation of a medicament for the prevention and/or treatment of diseases resulting from opening of the MPTP which are characterized by degenerative tissue damages, in particular, diabetes and diabetic complications, neurological diseases and stroke, heart infarction, inherited dystrophies and hepatitis, more particularly, diabetic vascular diseases, such as diabetic retinopathy, and neurodegenerative disorders, such as multiple sclerosis. Further objects are a group of selected individual compounds of formula (I) for use as medicaments and a further group of selected individual compounds of formula (I) as novel compounds.

    摘要翻译： 本发明公开了式（I）化合物的用途，其中R 1，R 2，R 3和R 4各自独立地表示：氢; 光环; 羟基; 任选被羟基或（C 1 -C 4）烷氧基取代的（C 1 -C 6）烷基; （C 1 -C 6）卤代烷基; （C 1 -C 6）烷氧基; 和（C 1 -C 6）卤代烷氧基; 用于制备用于预防和/或治疗MPTP开放引起的疾病的药物，其特征在于退行性组织损伤，特别是糖尿病和糖尿病并发症，神经系统疾病和中风，心脏梗死，遗传性营养不良和肝炎， 更具体地，糖尿病性血管疾病，例如糖尿病性视网膜病变，和神经变性疾病如多发性硬化。 另外的目的是用作药物的一组选定的式（I）化合物和另一组选择的式（I）化合物作为新化合物。

    USE OF METHIONINE SULFOXIMINE TO TREAT DISEASES CAUSED BY AN INFLAMMATORY CYTOKINE RESPONSE
    4.
    发明申请
    USE OF METHIONINE SULFOXIMINE TO TREAT DISEASES CAUSED BY AN INFLAMMATORY CYTOKINE RESPONSE 有权
    使用甲硫氨酸治疗由炎症细胞因子反应引起的疾病

    公开(公告)号：US20160081958A1

    公开(公告)日：2016-03-24

    申请号：US14833543

    申请日：2015-08-24

    申请人： William Brusilow ,  Paolo Bernardi

    发明人： William Brusilow ,  Paolo Bernardi

    IPC分类号： A61K31/198

    CPC分类号： A61K31/198 ,  A61K9/0019

    摘要： Methods for treating or preventing an inflammatory response comprising administering a diastereomer or diastereomeric mixture of methionine sulfoximine (MSO). The MSO may be L-methionine S-sulfoximine (LSMSO), L-methionine R-sulfoximine (LRMSO), or diastereomeric mixture of LSMSO and LRMSO. Methods include those for treating liver failure associated with an inflammatory response.

    摘要翻译： 用于治疗或预防炎性反应的方法，包括施用甲硫氨酸亚砜亚胺（MSO）的非对映体或非对映体混合物。 MSO可以是L-甲硫氨酸S-亚磺酰亚胺（LSMSO），L-甲硫氨酸R-亚磺酰亚胺（LRMSO）或LSMSO和LRMSO的非对映体混合物。 方法包括用于治疗与炎症反应相关的肝衰竭的方法。

    METHOD OF PRODUCING PANELS OF WOOD OR SIMILAR
    5.
    发明申请
    METHOD OF PRODUCING PANELS OF WOOD OR SIMILAR 审中-公开
    生产木材或类似面板的方法

    公开(公告)号：US20100006222A1

    公开(公告)日：2010-01-14

    申请号：US12499551

    申请日：2009-07-08

    申请人： Paolo BERNARDI

    发明人： Paolo BERNARDI

    IPC分类号： B29C65/02 ,  B29C65/52

    CPC分类号： B32B37/1207 ,  B32B37/06 ,  B32B37/1284 ,  B32B37/146 ,  B32B37/18 ,  B32B2305/024 ,  B32B2317/16 ,  B32B2607/00

    摘要： A panel of wood or similar, having a filling structure between two parallel, substantially flat sheets of wood or similar, is produced by heating the sheets and/or the filling structure; applying glue or similar to the heated sheets and/or filling structure; and assembling the sheets and the filling structure.

    摘要翻译： 通过加热片材和/或填充结构产生具有在两个平行的基本平坦的木材或类似木材之间的填充结构的木材或类似物的面板; 对加热的片材和/或填充结构施加胶水或类似物品; 并组装片材和填充结构。

    OPERATING HEAD
    7.
    发明申请
    OPERATING HEAD 有权
    操作头

    公开(公告)号：US20090324355A1

    公开(公告)日：2009-12-31

    申请号：US12487462

    申请日：2009-06-18

    申请人： Paolo BERNARDI

    发明人： Paolo BERNARDI

    IPC分类号： B23C1/00

    CPC分类号： B23Q5/043 ,  B23Q16/102 ,  Y10T409/30448 ,  Y10T409/307672 ,  Y10T409/308232 ,  Y10T409/308456 ,  Y10T409/309296 ,  Y10T409/309352

    摘要： In an operating head, a tool assembly is provided with an inlet shaft engaged on an electrospindle and pivotally engaged through a corresponding containing casing, which is oriented about a longitudinal axis of the electrospindle by means of an electric motor coaxially mounted to the axis and provided with a rotor coupled in an angularly fixed manner to the casing itself.

    摘要翻译： 在操作头中，工具组件设置有接合在电主轴上的入口轴，并且枢转地接合穿过相应的容纳壳体，所述对应的容纳壳体通过同轴地安装到轴线的电动机绕电动主轴的纵向轴线定向并提供 其中转子以角度固定的方式联接到壳体本身。

    USE OF METHIONINE SULFOXIMINE TO TREAT ACUTE LIVER FAILURE AND OTHER DISEASES CAUSED BY AN INFLAMMATORY CYTOKINE RESPONSE
    8.
    发明申请
    USE OF METHIONINE SULFOXIMINE TO TREAT ACUTE LIVER FAILURE AND OTHER DISEASES CAUSED BY AN INFLAMMATORY CYTOKINE RESPONSE 有权
    使用甲硫氨酸治疗由炎症细胞因子反应引起的急性肝衰竭及其他疾病

    公开(公告)号：US20140121277A1

    公开(公告)日：2014-05-01

    申请号：US14021653

    申请日：2013-09-09

    申请人： William Brusilow ,  Paolo Bernardi

    发明人： William Brusilow ,  Paolo Bernardi

    IPC分类号： A61K31/198

    CPC分类号： A61K31/198 ,  A61K9/0019

    摘要： Methods for treating or preventing an inflammatory response comprising administering an enantiomer or racemic mixture of methionine sulfoximine (MSO). The MSO may be L-methionine S-sulfoximine (LSMSO), L-methionine R-sulfoximine (LRMSO), or racemic mixture of LSMSO and LRMSO. Methods include those for treating liver failure associated with an inflammatory response.

    摘要翻译： 用于治疗或预防炎症反应的方法，包括给予甲硫氨酸亚砜亚胺（MSO）的对映异构体或外消旋混合物。 MSO可以是L-甲硫氨酸S-亚砜亚胺（LSMSO），L-甲硫氨酸R-亚磺酰亚胺（LRMSO）或LSMSO和LRMSO的外消旋混合物。 方法包括用于治疗与炎症反应相关的肝衰竭的方法。

    Operating head
    9.
    发明授权
    Operating head 有权
    操作头

    公开(公告)号：US08414232B2

    公开(公告)日：2013-04-09

    申请号：US12487462

    申请日：2009-06-18

    申请人： Paolo Bernardi

    发明人： Paolo Bernardi

    IPC分类号： B23C1/12

    CPC分类号： B23Q5/043 ,  B23Q16/102 ,  Y10T409/30448 ,  Y10T409/307672 ,  Y10T409/308232 ,  Y10T409/308456 ,  Y10T409/309296 ,  Y10T409/309352

    摘要： In an operating head, a tool assembly is provided with an inlet shaft engaged on an electrospindle and pivotally engaged through a corresponding containing casing, which is oriented about a longitudinal axis of the electrospindle by means of an electric motor coaxially mounted to the axis and provided with a rotor coupled in an angularly fixed manner to the casing itself.

    摘要翻译： 在操作头中，工具组件设置有接合在电主轴上的入口轴，并且枢转地接合穿过相应的容纳壳体，所述对应的容纳壳体通过同轴地安装到轴线的电动机绕电动主轴的纵向轴线定向并提供 其中转子以角度固定的方式联接到壳体本身。

    Use of methionine sulfoximine to treat diseases caused by an inflammatory cytokine response
    10.
    发明授权
    Use of methionine sulfoximine to treat diseases caused by an inflammatory cytokine response 有权
    使用甲硫氨酸亚砜亚胺治疗由炎性细胞因子反应引起的疾病

    公开(公告)号：US09561203B2

    公开(公告)日：2017-02-07

    申请号：US14833543

    申请日：2015-08-24

    申请人： William Brusilow ,  Paolo Bernardi

    发明人： William Brusilow ,  Paolo Bernardi

    IPC分类号： A61K31/198

    CPC分类号： A61K31/198 ,  A61K9/0019

    摘要： Methods for treating or preventing an inflammatory response comprising administering a diastereomer or diastereomeric mixture of methionine sulfoximine (MSO). The MSO may be L-methionine S-sulfoximine (LSMSO), L-methionine R-sulfoximine (LRMSO), or diastereomeric mixture of LSMSO and LRMSO. Methods include those for treating liver failure associated with an inflammatory response.

    摘要翻译： 用于治疗或预防炎性反应的方法，包括施用甲硫氨酸亚砜亚胺（MSO）的非对映体或非对映体混合物。 MSO可以是L-甲硫氨酸S-亚磺酰亚胺（LSMSO），L-甲硫氨酸R-亚磺酰亚胺（LRMSO）或LSMSO和LRMSO的非对映体混合物。 方法包括用于治疗与炎症反应相关的肝衰竭的方法。