公开(公告)号：US20100099736A1

公开(公告)日：2010-04-22

申请号：US12444407

申请日：2007-09-21

申请人： PierGiuseppe Pellicci ,  Marco Giorgio ,  Saverio Minucci ,  Paolo Bernardi ,  Gilles Pain ,  Stephen Martin Courtney ,  Christopher John Yarnold ,  Joachim Kraemer

发明人： PierGiuseppe Pellicci ,  Marco Giorgio ,  Saverio Minucci ,  Paolo Bernardi ,  Gilles Pain ,  Stephen Martin Courtney ,  Christopher John Yarnold ,  Joachim Kraemer

IPC分类号： A61K31/4015 ,  A61P25/00 ,  A61P3/10

CPC分类号： A61K31/4025 ,  C07D207/444 ,  C07D207/448 ,  C07D207/452 ,  Y10S514/866

摘要： The invention discloses the use of a compound of formula (I), wherein R1, R2, R3, and R4 each independently represents: hydrogen; halo; hydroxy; (C1-C6) alkyl optionally substituted by hydroxy or (C1-C4) alkoxy; (C1-C6) haloalkyl; (C1-C6) alkoxy; and (C1-C6) haloalkoxy; for the preparation of a medicament for the prevention and/or treatment of diseases resulting from opening of the MPTP which are characterized by degenerative tissue damages, in particular, diabetes and diabetic complications, neurological diseases and stroke, heart infarction, inherited dystrophies and hepatitis, more particularly, diabetic vascular diseases, such as diabetic retinopathy, and neurodegenerative disorders, such as multiple sclerosis. Further objects are a group of selected individual compounds of formula (I) for use as medicaments and a further group of selected individual compounds of formula (I) as novel compounds.

摘要翻译： 本发明公开了式（I）化合物的用途，其中R 1，R 2，R 3和R 4各自独立地表示：氢; 光环; 羟基; 任选被羟基或（C 1 -C 4）烷氧基取代的（C 1 -C 6）烷基; （C 1 -C 6）卤代烷基; （C 1 -C 6）烷氧基; 和（C 1 -C 6）卤代烷氧基; 用于制备用于预防和/或治疗MPTP开放引起的疾病的药物，其特征在于退行性组织损伤，特别是糖尿病和糖尿病并发症，神经系统疾病和中风，心脏梗死，遗传性营养不良和肝炎， 更具体地，糖尿病性血管疾病，例如糖尿病性视网膜病变，和神经变性疾病如多发性硬化。 另外的目的是用作药物的一组选定的式（I）化合物和另一组选择的式（I）化合物作为新化合物。

公开(公告)号：US08553528B2

公开(公告)日：2013-10-08

申请号：US12919201

申请日：2008-10-17

申请人： Marco Giorgio Ghibaudo ,  Beatriz Garriga ,  Luis Zas ,  Jose Angel Perez

发明人： Marco Giorgio Ghibaudo ,  Beatriz Garriga ,  Luis Zas ,  Jose Angel Perez

IPC分类号： G01R31/08

CPC分类号： H04M11/062 ,  H04L12/5692

摘要： The present invention relates to an apparatus (100) for the connection of at least one electronic device (30) to a telecommunication network comprising a fixed telecommunication network (40) and a mobile telecommunication network (41). The apparatus (100) comprises connecting means (20) for connecting said at least one electronic device (30) and a first interface (21) able to exchange data/voice with a fixed telecommunication network (40). The apparatus (100) further comprises a second interface (22) able to exchange data/voice with a mobile telecommunication network (41), a connection manager (60) for establishing a communication between said connecting means (20) with said first interface (21) and/or said second interface (22), and control means (61) in signal communication with said connection manager (60) and able to generate a control signal to control said connection manager (61), so as to determine the exchange of data/voice between the electronic device (30) connected to the connecting means (20) and the fixed telecommunication network (40) and/or the mobile telecommunication network (41).

摘要翻译： 本发明涉及一种用于将至少一个电子设备（30）连接到包括固定电信网络（40）和移动电信网络（41）的电信网络的装置（100）。 所述设备（100）包括用于连接所述至少一个电子设备（30）和能够与固定电信网络（40）交换数据/语音的第一接口（21）的连接装置（20）。 所述设备（100）还包括能够与移动电信网络（41）交换数据/语音的第二接口（22），用于在所述连接装置（20）与所述第一接口（20）建立通信的连接管理器（60） 21）和/或所述第二接口（22）以及与所述连接管理器（60）信号通信并且能够产生控制信号以控制所述连接管理器（61）的控制装置（61），以便确定所述交换 在与连接装置（20）和固定电信网络（40）和/或移动电信网络（41）连接的电子设备（30）之间的数据/语音。

公开(公告)号：US07915304B2

公开(公告)日：2011-03-29

申请号：US12444407

申请日：2007-09-21

申请人： PierGiuseppe Pellicci ,  Marco Giorgio ,  Saverio Minucci ,  Paolo Bernardi ,  Gilles Pain ,  Stephen Martin Courtney ,  Christopher John Yarnold ,  Joachim Kraemer

发明人： PierGiuseppe Pellicci ,  Marco Giorgio ,  Saverio Minucci ,  Paolo Bernardi ,  Gilles Pain ,  Stephen Martin Courtney ,  Christopher John Yarnold ,  Joachim Kraemer

IPC分类号： A01N43/36 ,  A61K31/40

CPC分类号： A61K31/4025 ,  C07D207/444 ,  C07D207/448 ,  C07D207/452 ,  Y10S514/866

摘要： The invention discloses the use of a compound of formula (I), wherein R1, R2, R3, and R4 each independently represents: hydrogen; halo; hydroxy; (C1-C6) alkyl optionally substituted by hydroxy or (C1-C4) alkoxy; (C1-C6) haloalkyl; (C1-C6) alkoxy; and (C1-C6) haloalkoxy; for the preparation of a medicament for the prevention and/or treatment of diseases resulting from opening of the MPTP which are characterized by degenerative tissue damages, in particular, diabetes and diabetic complications, neurological diseases and stroke, heart infarction, inherited dystrophies and hepatitis, more particularly, diabetic vascular diseases, such as diabetic retinopathy, and neurodegenerative disorders, such as multiple sclerosis. Further objects are a group of selected individual compounds of formula (I) for use as medicaments and a further group of selected individual compounds of formula (I) as novel compounds.

摘要翻译： 本发明公开了式（I）化合物的用途，其中R 1，R 2，R 3和R 4各自独立地表示：氢; 光环; 羟基; 任选被羟基或（C 1 -C 4）烷氧基取代的（C 1 -C 6）烷基; （C 1 -C 6）卤代烷基; （C 1 -C 6）烷氧基; 和（C 1 -C 6）卤代烷氧基; 用于制备用于预防和/或治疗MPTP开放引起的疾病的药物，其特征在于退行性组织损伤，特别是糖尿病和糖尿病并发症，神经系统疾病和中风，心脏梗死，遗传性营养不良和肝炎， 更具体地，糖尿病性血管疾病，例如糖尿病性视网膜病变，和神经变性疾病如多发性硬化。 另外的目的是用作药物的一组选定的式（I）化合物和另一组选择的式（I）化合物作为新化合物。