公开(公告)号：US09981895B1

公开(公告)日：2018-05-29

申请号：US15083707

申请日：2016-03-29

申请人： Parnative, Inc.

发明人： Benjamin Clayton ,  Jeremy Bandy

IPC分类号： C07C39/23 ,  C07C37/68 ,  C07C37/20 ,  A61K31/05 ,  A61K9/00 ,  A23L1/30

CPC分类号： C07C39/23 ,  A23L1/3002 ,  A23V2002/00 ,  A61K9/0053 ,  A61K31/05 ,  C07C37/20 ,  C07C37/68 ,  C07C39/215

摘要： Composition, methods of synthesizing trans-arachidin-3; and, methods of use as a dietary supplement, food additive, pharmaceutical, nutraceutical, cosmeceutical, and antioxidant. The methods of production entail organic syntheses using primary alkylamines or primary hydroxyalkyl amines, or carboxy amines (amino acids) with natural carboxylic acids (acetic acid) as catalysts to react isovaleraldehye with trans-resveratrol. The synthesis is carried out in organic solvent, which is composed of an azeotropic mixture comprising toluene with pyridine, n-butanol, n-propanol, 2-propanol, 2-methyl-1-propanol, or other alcohols that form an azeotrope with toluene. The final product is purified and analyzed for the amount of trans-arachidin-3, such as via HPLC, IR, column chromatography, and high-performance counter-current chromatography. All solvent and catalysts used in the reaction are approved by the FDA as either food additives, secondary direct food additives, and/or indirect food additives, and thus this synthetic trans-arachidin-3 may be used in the food and cosmetic industry.