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    Compositions and methods of synthesizing arachidin-3 from resveratrol
    1.
    发明授权
    Compositions and methods of synthesizing arachidin-3 from resveratrol 有权

    公开(公告)号：US09981895B1

    公开(公告)日：2018-05-29

    申请号：US15083707

    申请日：2016-03-29

    申请人： Parnative, Inc.

    发明人： Benjamin Clayton ,  Jeremy Bandy

    IPC分类号： C07C39/23 ,  C07C37/68 ,  C07C37/20 ,  A61K31/05 ,  A61K9/00 ,  A23L1/30

    CPC分类号： C07C39/23 ,  A23L1/3002 ,  A23V2002/00 ,  A61K9/0053 ,  A61K31/05 ,  C07C37/20 ,  C07C37/68 ,  C07C39/215

    摘要： Composition, methods of synthesizing trans-arachidin-3; and, methods of use as a dietary supplement, food additive, pharmaceutical, nutraceutical, cosmeceutical, and antioxidant. The methods of production entail organic syntheses using primary alkylamines or primary hydroxyalkyl amines, or carboxy amines (amino acids) with natural carboxylic acids (acetic acid) as catalysts to react isovaleraldehye with trans-resveratrol. The synthesis is carried out in organic solvent, which is composed of an azeotropic mixture comprising toluene with pyridine, n-butanol, n-propanol, 2-propanol, 2-methyl-1-propanol, or other alcohols that form an azeotrope with toluene. The final product is purified and analyzed for the amount of trans-arachidin-3, such as via HPLC, IR, column chromatography, and high-performance counter-current chromatography. All solvent and catalysts used in the reaction are approved by the FDA as either food additives, secondary direct food additives, and/or indirect food additives, and thus this synthetic trans-arachidin-3 may be used in the food and cosmetic industry.

    Water dispersible diethylstilbestrol compositions
    4.
    发明授权
    Water dispersible diethylstilbestrol compositions 失效
    水分散的二乙酸酯组合物

    公开(公告)号：US3639637A

    公开(公告)日：1972-02-01

    申请号：US3639637D

    申请日：1968-04-23

    申请人： RICHARDSON MERRELL INC

    发明人： CAMPBELL JAMES A

    IPC分类号： A23K1/165 ,  C07C39/215 ,  A61K27/00 ,  A61K17/06

    CPC分类号： C07C39/215 ,  A23K20/168 ,  A23K20/184

    摘要： WATER-DISPERSIBLE DIETHYLSTILLBESTROL COMPOSITIONS COMPRISING FINELY-DIVIDED DIETHYLSTILLBESTROL AND 70 TO 95 PERCENT OF A WATER-DOSPERSIBLE, GEL FORMING MICRYSTALLINE CELLULOSE HYDROCLLOID AND PREFERABLY ALSO CONTAINING SMALL AMOUNTS OF A DISPERSING AGENT SUCH AS SODIUM CARBOXYMETHYLCELLULOSE AND OTHER SIMILAR HHYDROCOLLOIDS. THE DRY MIXTURE IS SIMPLY MIXED WITH WATER FOR FROM 5 TO 30 MINUTES TO OBTAIN A STABLE AQUEOUS SUSPENSION OF THE DIETHYLSTILBESTROL.