公开(公告)号：US06455683B1

公开(公告)日：2002-09-24

申请号：US09531056

申请日：2000-03-20

申请人： Guchen Yang ,  Xiaorong Chen ,  Patricia M. Davis ,  Peter A. Kiener

发明人： Guchen Yang ,  Xiaorong Chen ,  Patricia M. Davis ,  Peter A. Kiener

IPC分类号： C07H2102

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/4726 ,  C07K14/7056 ,  C07K2319/00

摘要： Isolated novel cDNA sequences encoding a human C-type lectin and three homologues are provided. They are referred to herein as “CLAX” (C-type Lectin, Activation Expressed) proteins. The invention also includes methods of using the nucleic acid sequences, polypeptides encoded by the nucleic acid sequences disclosed herein, fusion proteins having all or a portion (e.g., an extracellular region) of the CLAX proteins, antibodies specific for the novel CLAXs, ligands and inhibitors for the novel CLAXs. The genes of CLAX are specifically expressed in lymphoid tissues and activated T lymphocytes but not resting T lymphocytes. The invention concerns the utility in pharmaceutical compositions for the prevention and treatment of infectious, inflammatory and allergic diseases.

摘要翻译： 提供了编码人C型凝集素和三个同系物的分离的新型cDNA序列。 它们在本文中称为“CLAX”（C型凝集素，激活表达的）蛋白质。 本发明还包括使用核酸序列的方法，由本文公开的核酸序列编码的多肽，具有CLAX蛋白的全部或部分（例如细胞外区域）的融合蛋白，对于新型CLAXs具有特异性的抗体，配体和 新型CLAXs的抑制剂。 CLAX的基因在淋巴组织和活化的T淋巴细胞中特异性表达，但不是休息的T淋巴细胞。 本发明涉及用于预防和治疗感染性，炎性和过敏性疾病的药物组合物中的应用。