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1.发明授权Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them 有权Diosmetin化合物，其制备方法和含有它们的药物组合物公开(公告)号：US08138223B2
公开(公告)日：2012-03-20
申请号：US12383888
申请日：2009-03-30
申请人： Michel Wierzbicki , Marie-Françoise Boussard , Tony Verbeuren , Patricia Sansilvestri-Morel , Alain Rupin , Jérôme Paysant , François Lefoulon
发明人： Michel Wierzbicki , Marie-Françoise Boussard , Tony Verbeuren , Patricia Sansilvestri-Morel , Alain Rupin , Jérôme Paysant , François Lefoulon
IPC分类号： A01N43/16
CPC分类号： C07D311/30 , C07D407/12 , C07H15/203 , C07H17/07
摘要： Compounds of formula (I): wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): Medicinal products containing the same which are useful in the prevention and/or treatment of venous diseases and other conditions.
摘要翻译： 式（I）化合物：其中可以相同或不同的R 1，R 2和R 3各自表示氢原子或式（A）的基团：含有其的药物，其可用于预防和/或 治疗静脉疾病等病症。
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2.发明申请Diosmetin compounds, a process for their preparation and pharmaceutical composition containing them 有权Diosmetin化合物，其制备方法和含有它们的药物组合物公开(公告)号：US20090247621A1
公开(公告)日：2009-10-01
申请号：US12383888
申请日：2009-03-30
申请人： Michel Wierzbicki , Marie-Francoise Boussard , Tony Verbeuren , Patricia Sansilvestri-Morel , Alain Rupin , Jerome Paysant , Francois Lefoulon
发明人： Michel Wierzbicki , Marie-Francoise Boussard , Tony Verbeuren , Patricia Sansilvestri-Morel , Alain Rupin , Jerome Paysant , Francois Lefoulon
IPC分类号： A61K31/352 , C07D311/02 , A61P9/00 , A61P3/00
CPC分类号： C07D311/30 , C07D407/12 , C07H15/203 , C07H17/07
摘要： Compounds of formula (I): wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): Medicinal products containing the same which are useful in the prevention and/or treatment of venous diseases and other conditions.
摘要翻译： 式（I）化合物：其中可以相同或不同的R 1，R 2和R 3各自表示氢原子或式（A）的基团：含有其的药物，其可用于预防和/或 治疗静脉疾病等病症。
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3.发明申请Use Of Diosmetin Compounds In The Treatment And Prevention Of Thrombotic Pathologies 审中-公开Diosmetin化合物在治疗和预防血栓病理学中的应用公开(公告)号：US20080176934A1
公开(公告)日：2008-07-24
申请号：US11885372
申请日：2006-02-28
申请人： Tony Verbeuren , Alain Rupin , Patricia Sansilvestri-Morel , Marie-Odile Vallez , Marie-Francoise Boussard , Michel Wierzbicki
发明人： Tony Verbeuren , Alain Rupin , Patricia Sansilvestri-Morel , Marie-Odile Vallez , Marie-Francoise Boussard , Michel Wierzbicki
IPC分类号： A61K31/352 , A61P9/00
CPC分类号： A61K31/352
摘要： Use of diosmetin compounds in obtaining pharmaceutical compositions intended for the prevention and/or treatment of thrombotic pathologies and pathologies with a risk of thrombosis.
摘要翻译： 在获得用于预防和/或治疗具有血栓形成风险的血栓形成病理和病理学的药物组合物中的用途。
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4.发明授权Diosmetin compounds, a process for their preparation and pharmaceutical compositions containing them 有权Diosmetin化合物，其制备方法和含有它们的药物组合物公开(公告)号：US08404742B2
公开(公告)日：2013-03-26
申请号：US13372811
申请日：2012-02-14
申请人： Michel Wierzbicki , Marie-Francoise Boussard , Tony Verbeuren , Patricia Sansilvestri-Morel , Alain Rupin , Jérôme Paysant , François Lefoulon
发明人： Michel Wierzbicki , Marie-Francoise Boussard , Tony Verbeuren , Patricia Sansilvestri-Morel , Alain Rupin , Jérôme Paysant , François Lefoulon
CPC分类号： C07D311/30 , C07D407/12 , C07H15/203 , C07H17/07
摘要： Compounds of formula (I): wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): Medicinal products containing the same which are useful in the prevention and/or treatment of venous diseases and other conditions.
摘要翻译： 式（I）化合物：其中可以相同或不同的R 1，R 2和R 3各自表示氢原子或式（A）的基团：含有其的药物，其可用于预防和/或 治疗静脉疾病等病症。
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5.发明申请DIOSMETIN COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权二异氰酸酯化合物，其制备方法和含有它们的药物组合物公开(公告)号：US20120208777A1
公开(公告)日：2012-08-16
申请号：US13372811
申请日：2012-02-14
申请人： Michel WIERZBICKI , Marie-Françoise BOUSSARD , Tony VERBEUREN , Patricia SANSILVESTRI-MOREL , Alain RUPIN , Jérôme PAYSANT , François LEFOULON
发明人： Michel WIERZBICKI , Marie-Françoise BOUSSARD , Tony VERBEUREN , Patricia SANSILVESTRI-MOREL , Alain RUPIN , Jérôme PAYSANT , François LEFOULON
IPC分类号： A61K31/353 , A61P7/02 , A61P7/00 , A61P25/00 , A61P9/10 , A61P17/02 , A61P9/14 , A61P1/04 , A61K31/7048 , A61P3/00
CPC分类号： C07D311/30 , C07D407/12 , C07H15/203 , C07H17/07
摘要： Compounds of formula (I): wherein R1, R2 and R3, which may be the same or different, each represent a hydrogen atom or the group of formula (A): Medicinal products containing the same which are useful in the prevention and/or treatment of venous diseases and other conditions.
摘要翻译： 式（I）化合物：其中可以相同或不同的R 1，R 2和R 3各自表示氢原子或式（A）的基团：含有其的药物，其可用于预防和/或 治疗静脉疾病等病症。
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6.发明申请Association between an anti-atherothrombotic and an angiotensin-converting enzyme inhibitor 审中-公开抗动脉粥样硬化血栓形成与血管紧张素转换酶抑制剂之间的联系公开(公告)号：US20090075976A1
公开(公告)日：2009-03-19
申请号：US12231981
申请日：2008-09-08
申请人： Tony Verbeuren , Patricia Sansilvestri-Morel , Alain Rupin , Marie-Odile Vallez , Marie-Dominique Fratacci , Laurence Lerond , Gilbert Lavielle
发明人： Tony Verbeuren , Patricia Sansilvestri-Morel , Alain Rupin , Marie-Odile Vallez , Marie-Dominique Fratacci , Laurence Lerond , Gilbert Lavielle
CPC分类号： C07D209/42 , A61K31/18 , A61K31/404 , A61K45/06 , C07C311/20 , A61K2300/00
摘要： The present invention relates to the association of an anti-atherothrombotic and an angiotensin-converting enzyme inhibitor (ACEI), and also to pharmaceutical compositions containing them, and to methods of treating vascular complications associated with diabetes, with atherothrombotic diseases, with hyperlipidaemia, with hypertension, with chronic venous diseases, with inflammation, with metabolic syndrome associated with obesity, or with cancer, with such association.
摘要翻译： 本发明涉及抗动脉粥样硬化血栓形成和血管紧张素转化酶抑制剂（ACEI）的联合，以及含有它们的药物组合物的联合，以及治疗与糖尿病相关的血管并发症的方法，具有动脉粥样硬化血栓形成疾病与高脂血症， 高血压，伴有慢性静脉疾病，炎症，与肥胖相关的代谢综合征或与癌症有关联。
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