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24 条记录 (耗时 0.029 秒)

    4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxamide compounds
    6.
    发明授权
    4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxamide compounds 失效
    4-氧代-4,6,7,8-四氢 - 吡咯并[1,2-a]吡嗪-6-甲酰胺化合物

    公开(公告)号：US07498330B2

    公开(公告)日：2009-03-03

    申请号：US11079638

    申请日：2005-03-14

    申请人： Guillaume De Nanteuil ,  Philippe Gloanec ,  Jean-Gilles Parmentier ,  Alain Benoist ,  Alain Rupin ,  Marie-Odile Vallez ,  Tony Verbeuren

    发明人： Guillaume De Nanteuil ,  Philippe Gloanec ,  Jean-Gilles Parmentier ,  Alain Benoist ,  Alain Rupin ,  Marie-Odile Vallez ,  Tony Verbeuren

    IPC分类号： A01N43/66 ,  A61K31/53 ,  C07D241/36

    CPC分类号： C07D487/04

    摘要： Compound of formula (I): wherein: represents 1-oxidopyridyl substituted by the remainder of the molecule in any one of the positions 2, 3 and 4, m and n, which may be identical or different, each represent an integer of from 1 to 3, R1 represents hydrogen or alkyl, R2 and R3, which may be identical or different, each represent an atom or group selected from hydrogen, halogen, alkyl, hydroxy, acyloxy and alkoxy, or, together with the carbon atom carrying them, form a cycloalkane having from 3 to 6 carbon atoms, R4 and R5 each represent hydrogen, or are adjacent and, together with the carbon atoms carrying them, form a benzo ring, Ar represents aryl or heteroaryl. Medicinal products containing the same which are useful as thrombin inhibitors.

    摘要翻译： 式（I）的化合物：其中：表示由位置2,3和4中的任一个中的分子的其余部分取代的1-氧化吡啶基，m和n可以相同或不同，各自表示1的整数 至3，R 1表示氢或烷基，可以相同或不同的R 2和R 3各自表示选自氢，卤素，烷基，羟基，酰氧基和烷氧基的原子或基团，或者与携带它们的碳原子一起， 形成具有3至6个碳原子的环烷烃，R 4和R 5各自表示氢或邻近，并且与携带它们的碳原子一起形成苯并环，Ar表示芳基或杂芳基。 含有该药物的药物可用作凝血酶抑制剂。

    4-oxo-4,6,7,8-Tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxamide compounds
    7.
    发明申请
    4-oxo-4,6,7,8-Tetrahydro-pyrrolo[1,2-a]pyrazine-6-carboxamide compounds 审中-公开
    4-氧代-4,6,7,8-四氢 - 吡咯并[1,2-a]吡嗪-6-甲酰胺化合物

    公开(公告)号：US20090131668A1

    公开(公告)日：2009-05-21

    申请号：US12321607

    申请日：2009-01-22

    申请人： Guillaume De Nanteuil ,  Philippe Gloanec ,  Jean-Gilles Parmentier ,  Alain Benoist ,  Alain Rupin ,  Marie-Odile Vallez ,  Tony Verbeuren

    发明人： Guillaume De Nanteuil ,  Philippe Gloanec ,  Jean-Gilles Parmentier ,  Alain Benoist ,  Alain Rupin ,  Marie-Odile Vallez ,  Tony Verbeuren

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： Compound of formula (I): wherein: represents 1-oxidopyridyl substituted by the remainder of the molecule in any one of the positions 2, 3 and 4, m and n, which may be identical or different, each represent an integer of from 1 to 3, R1 represents hydrogen or alkyl, R2 and R3, which may be identical or different, each represent an atom or group selected from hydrogen, halogen, alkyl, hydroxy, acyloxy and alkoxy, or, together with the carbon atom carrying them, form a cycloalkane having from 3 to 6 carbon atoms, R4 and R5 each represent hydrogen, or are adjacent and, together with the carbon atoms carrying them, form a benzo ring, Ar represents aryl or heteroaryl. Medicinal products containing the same which are useful as thrombin inhibitors.

    摘要翻译： 式（I）的化合物：其中：表示由位置2,3和4中的任一个中的分子的其余部分取代的1-氧化吡啶基，m和n可以相同或不同，各自表示1的整数 至3，R 1表示氢或烷基，可以相同或不同的R 2和R 3各自表示选自氢，卤素，烷基，羟基，酰氧基和烷氧基的原子或基团，或者与携带它们的碳原子一起， 形成具有3至6个碳原子的环烷烃，R 4和R 5各自表示氢或邻近，并且与携带它们的碳原子一起形成苯并环，Ar表示芳基或杂芳基。 含有该药物的药物可用作凝血酶抑制剂。

    Benzothiophene, benzofuran and indole compounds
    10.
    发明授权
    Benzothiophene, benzofuran and indole compounds 失效
    苯并噻吩，苯并呋喃和吲哚化合物

    公开(公告)号：US6048875A

    公开(公告)日：2000-04-11

    申请号：US299271

    申请日：1999-04-26

    申请人： Guillaume De Manteuil ,  Christine Lila ,  Tony Verbeuren ,  Alain Rupin

    发明人： Guillaume De Manteuil ,  Christine Lila ,  Tony Verbeuren ,  Alain Rupin

    IPC分类号： C07D333/58 ,  A61K31/00 ,  A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/505 ,  A61K31/506 ,  A61P7/00 ,  A61P7/02 ,  A61P43/00 ,  C07D333/60 ,  C07D333/64 ,  C07D401/06 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D495/04 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D333/64 ,  C07D401/06 ,  C07D409/06 ,  C07D409/14

    摘要： A compound of formula (I): ##STR1## wherein: X represents oxygen, sulphur, or NR.sub.3 wherein R.sub.3 is as defined in the description,Y represents oxygen, sulphur, NR.sub.3, or may a single bond when X represents NR.sub.3,Z represents nitrogen, carbon, or CH,A represents a single bond, alkylene (optionally substituted), arylene, cycloalkylene, heterocycle, or --SO.sub.2 --R.sub.4 -- wherein R.sub.4 is as defined in the description,W represents hydroxy, alkoxy, aryloxy, arylalkoxy, cycloalkyloxy, heterocycle bonded to oxygen, amino, or hydroxyamino,Ra, Rb, Rc, Rd, which may be the same or different, each independently of the others are as defined in the description,R.sub.1 represents aryl substituted by one to five identical or different substituents, each independently of the others,R.sub.2 represents hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, heterocycle, heterocycloalkyl, or another group as defined in the description,isomers and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful in the treatment of thrombosis, pathologies for which the origin is thrombosis, or pathologies causing an increase in risk of thrombosis.

    摘要翻译： 式（I）的化合物：其中：X表示氧，硫或NR 3，其中R3如说明书中所定义，Y表示氧，硫，NR 3，或当X表示NR 3时可以是单键，Z表示氮，碳 或CH，A表示单键，亚烷基（任选取代的），亚芳基，亚环烷基，杂环或-SO 2 -R 4 - ，其中R 4如说明书中所定义，W表示羟基，烷氧基，芳氧基，芳基烷氧基，环烷氧基，杂环 与氧，氨基或羟基氨基键合的R a，R b，R c，R d各自独立地相同或不同，如说明书中所定义，R 1表示被1至5个相同或不同取代基取代的芳基， R 2代表氢，烷基，芳基，芳基烷基，环烷基，杂环，杂环烷基或说明书中定义的另一基团，其与药学上可接受的酸或碱的异构体和加成盐，以及药用产品 可用于治疗血栓形成，起源于血栓形成的病理学，或导致血栓形成风险增加的病理学。