公开(公告)号：US08696952B2

公开(公告)日：2014-04-15

申请号：US11587251

申请日：2005-04-25

申请人： Eugenia Kumacheva ,  Shengqing Xu ,  Zhihong Nie ,  Min Seok Seo ,  Patrick Cameron Lewis ,  Hong Zhang

发明人： Eugenia Kumacheva ,  Shengqing Xu ,  Zhihong Nie ,  Min Seok Seo ,  Patrick Cameron Lewis ,  Hong Zhang

IPC分类号： B01J19/00 ,  C08F2/00

CPC分类号： C08J3/16 ,  A61K9/1641 ,  A61K9/1694 ,  A61K9/5031 ,  A61K9/5036 ,  B01F3/0807 ,  B01F5/0647 ,  B01F13/0062 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/0093 ,  B01J2219/00936 ,  B01J2219/00984 ,  B82Y10/00 ,  B82Y30/00 ,  Y10T436/2575

摘要： The present invention provides a method and apparatus for producing polymeric particles with pre-designed size, shape, morphology and composition, and more particularly the present invention uses a microfluidic polymerization reactor for producing same. The present invention disclosed herein provides a process for producing polymer particles with pre-selected shapes. The method includes injecting a first fluid comprising a polymerizable constituent with a controlled flow rate into a microfluidic channel and injecting a second fluid with a controlled flow rate into the microfluidic channel in which the second fluid mixes with the first fluid, the second fluid being immiscible with the first fluid so that the first fluid forms into droplets in the microfluidic channel. The microfluidic channel has pre-selected dimensions to give droplets of pre-selected size, morphology and shape. The microfluidic channel is sufficiently long so that the droplets have a sufficiently long residence time in the channel so that they polymerize or otherwise harden into droplets of pre-selected size and shape.

摘要翻译： 本发明提供了一种用于制备具有预先设计的尺寸，形状，形态和组成的聚合物颗粒的方法和装置，更具体地，本发明使用微流体聚合反应器来生产聚合物颗粒。 本文公开的本发明提供了一种用于制备具有预选形状的聚合物颗粒的方法。 该方法包括将包含可控流速的可聚合组分的第一流体注入微流体通道并将具有受控流速的第二流体注射到第二流体与第一流体混合的微流体通道中，第二流体是不混溶的 第一流体使得第一流体在微流体通道中形成液滴。 微流体通道具有预选的尺寸以产生预选尺寸，形态和形状的液滴。 微流体通道足够长，使得液滴在通道中具有足够长的停留时间，使得它们聚合或以其它方式硬化成预选尺寸和形状的液滴。

公开(公告)号：US20110129941A1

公开(公告)日：2011-06-02

申请号：US11587251

申请日：2005-04-25

申请人： Eugenia Kumacheva ,  Shengqing Xu ,  Zhihong Nie ,  Min Seok Seo ,  Patrick Cameron Lewis ,  Hong Zhang

发明人： Eugenia Kumacheva ,  Shengqing Xu ,  Zhihong Nie ,  Min Seok Seo ,  Patrick Cameron Lewis ,  Hong Zhang

IPC分类号： B01J19/00

CPC分类号： C08J3/16 ,  A61K9/1641 ,  A61K9/1694 ,  A61K9/5031 ,  A61K9/5036 ,  B01F3/0807 ,  B01F5/0647 ,  B01F13/0062 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/0093 ,  B01J2219/00936 ,  B01J2219/00984 ,  B82Y10/00 ,  B82Y30/00 ,  Y10T436/2575

摘要： The present invention provides a method and apparatus for producing polymeric particles with pre-designed size, shape, morphology and composition, and more particularly the present invention uses a microfluidic polymerization reactor for producing same. The present invention disclosed herein provides a process for producing polymer particles with pre-selected shapes. The method includes injecting a first fluid comprising a polymerizable constituent with a controlled flow rate into a microfluidic channel and injecting a second fluid with a controlled flow rate into the microfluidic channel in which the second fluid mixes with the first fluid, the second fluid being immiscible with the first fluid so that the first fluid forms into droplets in the microfluidic channel. The microfluidic channel has pre-selected dimensions to give droplets of pre-selected size, morphology and shape. The microfluidic channel is sufficiently long so that the droplets have a sufficiently long residence time in the channel so that they polymerize or otherwise harden into droplets of pre-selected size and shape.

摘要翻译： 本发明提供了一种用于制备具有预先设计的尺寸，形状，形态和组成的聚合物颗粒的方法和装置，更具体地，本发明使用微流体聚合反应器来生产聚合物颗粒。 本文公开的本发明提供了一种用于制备具有预选形状的聚合物颗粒的方法。 该方法包括将包含可控流速的可聚合组分的第一流体注入微流体通道并将具有受控流速的第二流体注射到第二流体与第一流体混合的微流体通道中，第二流体是不混溶的 第一流体使得第一流体在微流体通道中形成液滴。 微流体通道具有预选的尺寸以产生预选尺寸，形态和形状的液滴。 微流体通道足够长，使得液滴在通道中具有足够长的停留时间，使得它们聚合或以其它方式硬化成预选尺寸和形状的液滴。