公开(公告)号：US07422574B2

公开(公告)日：2008-09-09

申请号：US10374853

申请日：2003-02-25

申请人： Elof Eriksson ,  Christian Baker ,  W. Robert Allison ,  Tom Johnson ,  Anthony Downing ,  David Porait ,  Denis Labombard ,  John Navickas ,  Patrick Guiney

发明人： Elof Eriksson ,  Christian Baker ,  W. Robert Allison ,  Tom Johnson ,  Anthony Downing ,  David Porait ,  Denis Labombard ,  John Navickas ,  Patrick Guiney

IPC分类号： A61M5/00

CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K48/00 ,  A61K48/0083 ,  A61M5/145 ,  A61M2037/0023 ,  A61M2037/003

摘要： An apparatus is provided to enable the direct gene transfer of genetic material into a target cell site (“microseeding”), as a means of obtaining long term expression of native or non-native polypeptides in a host. The apparatus includes a matrix of microneedles that oscillate at a predetermined frequency and receive the genetic material from a delivery system that is integrated with the apparatus.

摘要翻译： 提供了一种能够将遗传物质直接转移到靶细胞部位（“微插入”）的装置，作为在宿主中获得天然或非天然多肽的长期表达的手段。 该装置包括以预定频率振荡并从与装置集成的输送系统接收遗传物质的微针矩阵。

公开(公告)号：US20090168160A1

公开(公告)日：2009-07-02

申请号：US12335390

申请日：2008-12-15

申请人： Patrick Guiney ,  Douglas A. Tenney

发明人： Patrick Guiney ,  Douglas A. Tenney

IPC分类号： G02B21/26 ,  G02B21/00

CPC分类号： G02B21/26 ,  G02B21/367

摘要： Methods and systems for scanning a cytological specimen carried by a slide. Movement or positioning of a motorized stage of an automated screening system may be controlled manually by a user such that the user controls movement, e.g., controlling speed, position, and/or timing, of the motorized stage along a first scan line to controllably scan a first portion of the specimen along the scan line. The user may then index the motorized stage from the first scan line to the next scan line and manually control movement of the stage along the second scan line to controllably scan another portion of the specimen. Stage indexing may also be automatic such that the user does not control or initiate indexing.

摘要翻译： 用于扫描载玻片携带的细胞学标本的方法和系统。 自动化筛选系统的机动台的移动或定位可以由用户手动控制，使得用户控制电动台沿着第一扫描线的运动，例如控制速度，位置和/或定时，以可控地扫描 沿着扫描线的样品的第一部分。 然后用户可以将电动台从第一扫描线索引到下一扫描线，并且手动地控制台沿着第二扫描线的移动，以可控地扫描样本的另一部分。 阶段索引也可以是自动的，使得用户不控制或启动索引。

公开(公告)号：US20070148041A1

公开(公告)日：2007-06-28

申请号：US11613169

申请日：2006-12-19

申请人： Barry Hunt ,  Peter Doward ,  Steven Scampini ,  Patrick Guiney ,  Peter Albany

发明人： Barry Hunt ,  Peter Doward ,  Steven Scampini ,  Patrick Guiney ,  Peter Albany

IPC分类号： G01N33/00

CPC分类号： G01N1/312

摘要： A system for preparing biological specimen slides comprises a slide preparation apparatus for preparing the specimen slides; a processor configured to control the slide preparation apparatus; and a data retrieval device coupled to the processor and configured to retrieve information from a storage device associated with the slide preparation apparatus or a component used by the slide preparation apparatus, wherein the processor selectively enables operation of the slide preparation apparatus based on the retrieved information.

摘要翻译： 用于制备生物标本载玻片的系统包括：用于制备标本片的载玻片制备装置; 处理器，被配置为控制所述滑块准备装置; 以及数据检索装置，其耦合到所述处理器并且被配置为从与所述幻灯片准备装置相关联的存储装置或由所述幻灯片准备装置使用的部件检索信息，其中所述处理器基于所检索的信息选择性地使得所述幻灯片准备装置的操作 。

公开(公告)号：US07140738B2

公开(公告)日：2006-11-28

申请号：US10998028

申请日：2004-11-24

申请人： Patrick Guiney ,  Scott Wolpert

发明人： Patrick Guiney ,  Scott Wolpert

IPC分类号： G03B23/00

CPC分类号： G03B23/00

摘要： System and method for calibrating the orientation or arrangement of slides in a storage receptacle. A reflective marking is asymmetrically applied to a side or edge of a slide, forming reflective and non-reflective sections. Light is directed to the slide, and a sensor detects light that is reflected by the reflective sections and generates signal or data representing an orientation of the slide. A controller processes the signal or data to determine whether the slide is properly oriented on a tray in the storage receptacle, e.g., whether the slide is flat or at an angle, upside down, rotated. The marking can be reflective ink, paint or an adhesive. Reflective and non-reflective markings can also be formed by laser etching, polishing, or by frosting.

公开(公告)号：US20060180489A1

公开(公告)日：2006-08-17

申请号：US11050547

申请日：2005-02-02

申请人： Patrick Guiney ,  Mark Bangert ,  Bernie Lane ,  Mathew McCormack ,  Robert Sakal

发明人： Patrick Guiney ,  Mark Bangert ,  Bernie Lane ,  Mathew McCormack ,  Robert Sakal

IPC分类号： B65D85/48

CPC分类号： B01L9/52 ,  B01L2200/025 ,  B01L2300/043 ,  B01L2300/0822 ,  G02B21/34

摘要： Apparatus and methods for loading a tray containing a plurality of slides into an imaging system, and for verifying the alignment and orientation of the tray in the imaging system. A plurality of retainers secures the slides in recesses defined by the tray. An aligning projection on the tray interacts with an alignment component on the imaging system to verify the alignment and orientation of the tray in the imaging system and to disable the system if it cannot do so.

摘要翻译： 用于将包含多个载玻片的托盘装载到成像系统中并用于验证成像系统中托盘的对准和取向的装置和方法。 多个保持器将滑块固定在由托盘限定的凹部中。 托盘上的对准投影与成像系统上的对准部件相互作用，以验证成像系统中托盘的对准和取向，并且如果不能这样做则禁用系统。

公开(公告)号：US20050100483A1

公开(公告)日：2005-05-12

申请号：US10712280

申请日：2003-11-12

申请人： Patrick Guiney

发明人： Patrick Guiney

IPC分类号： B01D35/143 ,  B01L3/00 ,  B01L11/00

CPC分类号： B01D35/143 ,  B01D2201/4046 ,  B01D2201/54 ,  B01L3/50255 ,  B01L2300/022 ,  B01L2300/024 ,  B01L2300/0829

摘要： Apparatus, system and method for preparing a sample of a biological specimen utilizing a filter tray having a data storage device. The data storage device stores data relating to filter compatibility, expiration, and processing steps and parameters. The storage device can be attached to or positioned within the filter tray. The storage device can also be interfaced to a sample processing system.

摘要翻译： 利用具有数据存储装置的过滤盘来制备生物试样的样品的装置，系统和方法。 数据存储装置存储与过滤器兼容性，到期和处理步骤和参数有关的数据。 存储装置可以附接到或定位在过滤盘内。 存储装置也可以与样品处理系统连接。

公开(公告)号：US08020305B2

公开(公告)日：2011-09-20

申请号：US12535581

申请日：2009-08-04

申请人： Patrick Guiney ,  Raymond Jenoski

发明人： Patrick Guiney ,  Raymond Jenoski

IPC分类号： G02B21/00 ,  G02B21/34

CPC分类号： B43K23/001 ,  G02B21/34

摘要： A detachable microscope pen mount for marking a microscope slide includes an attachment collar configured to secure to an objective lens, a lever secured to the attachment collar, a pen holder secured to the lever, and a pen secured to the pen holder and having a pen tip, where activating the lever moves the pen tip into a field of view and lowers the pen tip onto the microscope slide. Also disclosed is a method of marking a microscope slide includes identifying an object of interest in a field of view, positioning the object of interest in a center of the field of view, inserting a pen having a pen tip along a trough into a center of the trough, lowering the pen tip onto the microscope slide, and marking the microscope slide by tracing the inside of the center of the trough. Another method of marking a microscope slide includes identifying an object of interest in a field of view, positioning the object of interest in a center of the field of view, inserting a pen having a pen tip along a trough until it reaches an outside surface of a tube in the trough, lowering the pen tip onto the microscope slide, and marking the microscope slide by tracing the outside of tube.

摘要翻译： 用于标记显微镜载玻片的可拆卸的显微镜笔安装座包括被配置为固定到物镜，固定到附接轴环的杆，固定到杠杆的笔架和固定到笔架并且具有笔的笔 尖端，其中激活杠杆将笔尖移动到视场中并将笔尖降低到显微镜载玻片上。 还公开了一种标记显微镜幻灯片的方法，包括在视场中识别感兴趣的对象，将感兴趣的对象定位在视场的中心，将具有笔尖的笔沿着槽插入到 槽，将笔尖降到显微镜载玻片上，并通过跟踪槽中心的内部来标记显微镜载玻片。 标记显微镜幻灯片的另一种方法包括在视野中识别感兴趣的物体，将感兴趣的物体定位在视场的中心，沿着槽插入具有笔尖的笔，直到其到达外部表面 在槽中的管，将笔尖降到显微镜载玻片上，并通过跟踪管外标记显微镜载玻片。

公开(公告)号：US20100031519A1

公开(公告)日：2010-02-11

申请号：US12535581

申请日：2009-08-04

申请人： Patrick Guiney ,  Raymond Jenoski

发明人： Patrick Guiney ,  Raymond Jenoski

IPC分类号： B43L11/00 ,  G02B21/00 ,  A47B96/06

CPC分类号： B43K23/001 ,  G02B21/34

摘要： A detachable microscope pen mount for marking a microscope slide includes an attachment collar configured to secure to an objective lens, a lever secured to the attachment collar, a pen holder secured to the lever, and a pen secured to the pen holder and having a pen tip, where activating the lever moves the pen tip into a field of view and lowers the pen tip onto the microscope slide. Also disclosed is a method of marking a microscope slide includes identifying an object of interest in a field of view, positioning the object of interest in a center of the field of view, inserting a pen having a pen tip along a trough into a center of the trough, lowering the pen tip onto the microscope slide, and marking the microscope slide by tracing the inside of the center of the trough. Another method of marking a microscope slide includes identifying an object of interest in a field of view, positioning the object of interest in a center of the field of view, inserting a pen having a pen tip along a trough until it reaches an outside surface of a tube in the trough, lowering the pen tip onto the microscope slide, and marking the microscope slide by tracing the outside of tube.

摘要翻译： 用于标记显微镜载玻片的可拆卸的显微镜笔安装座包括被配置为固定到物镜，固定到附接轴环的杆，固定到杠杆的笔架和固定到笔架并且具有笔的笔 尖端，其中激活杠杆将笔尖移动到视场中并将笔尖降低到显微镜载玻片上。 还公开了一种标记显微镜幻灯片的方法，包括在视场中识别感兴趣的对象，将感兴趣的对象定位在视场的中心，将具有笔尖的笔沿着槽插入到 槽，将笔尖降到显微镜载玻片上，并通过跟踪槽中心的内部来标记显微镜载玻片。 标记显微镜幻灯片的另一种方法包括在视野中识别感兴趣的物体，将感兴趣的物体定位在视场的中心，沿着槽插入具有笔尖的笔，直到其到达外部表面 在槽中的管，将笔尖降到显微镜载玻片上，并通过跟踪管外标记显微镜载玻片。

公开(公告)号：US08174763B2

公开(公告)日：2012-05-08

申请号：US12335390

申请日：2008-12-15

申请人： Patrick Guiney ,  Douglas A. Tenney

发明人： Patrick Guiney ,  Douglas A. Tenney

IPC分类号： G02B21/26

CPC分类号： G02B21/26 ,  G02B21/367

摘要： Methods and systems for scanning a cytological specimen carried by a slide. Movement or positioning of a motorized stage of an automated screening system may be controlled manually by a user such that the user controls movement, e.g., controlling speed, position, and/or timing, of the motorized stage along a first scan line to controllably scan a first portion of the specimen along the scan line. The user may then index the motorized stage from the first scan line to the next scan line and manually control movement of the stage along the second scan line to controllably scan another portion of the specimen. Stage indexing may also be automatic such that the user does not control or initiate indexing.

摘要翻译： 用于扫描载玻片携带的细胞学标本的方法和系统。 自动化筛选系统的机动台的移动或定位可以由用户手动控制，使得用户控制电动台沿着第一扫描线的运动，例如控制速度，位置和/或定时，以可控地扫描 沿着扫描线的样品的第一部分。 然后用户可以将电动台从第一扫描线索引到下一扫描线，并且手动地控制台沿着第二扫描线的移动，以可控地扫描样本的另一部分。 阶段索引也可以是自动的，使得用户不控制或启动索引。

公开(公告)号：US20060109432A1

公开(公告)日：2006-05-25

申请号：US10998028

申请日：2004-11-24

申请人： Patrick Guiney ,  Scott Wolpert

发明人： Patrick Guiney ,  Scott Wolpert

IPC分类号： G03B23/00

CPC分类号： G03B23/00

摘要： System and method for calibrating the orientation or arrangement of slides in a storage receptacle. A reflective marking is asymmetrically applied to a side or edge of a slide, forming reflective and non-reflective sections. Light is directed to the slide, and a sensor detects light that is reflected by the reflective sections and generates signal or data representing an orientation of the slide. A controller processes the signal or data to determine whether the slide is properly oriented on a tray in the storage receptacle, e.g., whether the slide is flat or at an angle, upside down, rotated. The marking can be reflective ink, paint or an adhesive. Reflective and non-reflective markings can also be formed by laser etching, polishing, or by frosting.

摘要翻译： 用于校准滑块在存储容器中的取向或排列的系统和方法。 反射标记不对称地施加到滑块的侧面或边缘，形成反射和非反射部分。 光被引导到幻灯片，并且传感器检测由反射部分反射的光，并产生表示幻灯片的取向的信号或数据。 控制器处理信号或数据以确定滑块是否适当地定位在存储容器中的托盘上，例如滑块是平坦的还是以一定角度，倒置旋转。 标记可以是反光油墨，油漆或粘合剂。 反射和非反射标记也可以通过激光蚀刻，抛光或结霜形成。