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公开(公告)号：US5656157A
公开(公告)日：1997-08-12
申请号：US284060
申请日：1994-08-02
CPC分类号： B01D3/343 , B01D1/14 , F26B17/107
摘要： In apparatus for separating the components of a mixture, the mixture is admitted to a first inlet which communicates with a working region which may be defined by a cylindrical tube. A fluid under pressure is admitted to a chamber through a second inlet. The chamber also communicates with the working region. The fluid forms a spiralling flow which draws the mixture into the working region in the form of a vortex. In the apparatus, the chamber communicates with the working region by way of a throat, and the mixture is conveyed from the working region along an outlet.
摘要翻译： 在用于分离混合物的组分的装置中，混合物被允许进入与可由圆柱形管限定的工作区域连通的第一入口。 压力下的流体通过第二入口进入腔室。 该室还与工作区域进行通信。 流体形成螺旋流，其以混合物的形式将混合物吸入工作区域。 在该装置中，室通过喉部与工作区域连通，并且混合物沿着出口从工作区域输送。
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公开(公告)号：US07552517B2
公开(公告)日：2009-06-30
申请号：US11581721
申请日：2006-10-16
申请人： James Patrick McKee
发明人： James Patrick McKee
IPC分类号： A44B21/00
CPC分类号： F16G3/00 , B65G15/00 , Y10S24/35 , Y10T24/3969 , Y10T24/44009 , Y10T24/44043 , Y10T24/45005 , Y10T24/45079
摘要： An apparatus and method are provided for clamping a belt with a quick clamping action. The apparatus and method employ an impact force applied to a clamping device that causes a clamping portion of the clamping device to be driven into clamping engagement with the belt received in a housing for the clamping device. In one form, the clamping device has a clamp actuator that includes an impact receiving end preferably disposed outside the housing and a clamp member in the housing that is driven into clamping engagement with the belt by the actuator. The preferred belt clamp has the actuator and clamp member configured so that during belt pulling operations, the clamp also self-locks onto the belt to increase the clamping force applied thereto. In another aspect, the housing preferably has wall portions of varying thickness to provide increased strength where needed while keeping the weight thereof to a minimum.
摘要翻译： 提供了一种用于以快速夹紧动作夹紧皮带的装置和方法。 该装置和方法采用施加到夹紧装置上的冲击力，该冲击力使夹紧装置的夹紧部分被驱动成与容纳在用于夹紧装置的壳体中的皮带夹紧接合。 在一种形式中，夹紧装置具有夹紧致动器，其包括优选地设置在壳体外部的冲击接收端和壳体中的夹紧构件，该夹紧构件通过致动器被驱动与带夹紧接合。 优选的皮带夹具具有致动器和夹紧构件，其构造成使得在皮带牵引操作期间，夹具还自动锁定到皮带上以增加施加到其上的夹紧力。 另一方面，壳体优选地具有不同厚度的壁部分，以在需要时提供增加的强度，同时将其重量保持在最小。
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3.发明申请Substrates and inhibitors of antiplasmin cleaving enzyme and methods of use 审中-公开抗肿瘤酶切割酶的底物和抑制剂及其使用方法公开(公告)号：US20080057491A1
公开(公告)日：2008-03-06
申请号：US11811002
申请日：2007-06-06
CPC分类号： C07K14/8121 , A61K38/00
摘要： The present invention is directed toward inhibitors of antiplasmin cleaving enzyme for use in various therapies related to fibrin and α2-antiplasmin, and to substrates of APCE, which may be used, for example, in screening methods for identifying such inhibitors. The present invention is further directed to methods of treating or inhibiting atherosclerosis and thrombus disorders by altering the rations of types of plasma α2-antiplasmin.
摘要翻译： 本发明涉及用于与纤维蛋白和α2 - 对映体相关的各种疗法的抗血浆酶切割酶的抑制剂，以及APCE的底物，其可用于例如筛选方法 鉴定这种抑制剂。 本发明还涉及通过改变血浆α2 - 阿米卡星类型的比例来治疗或抑制动脉粥样硬化和血栓紊乱的方法。
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4.发明申请公开(公告)号：US20080314051A1
公开(公告)日：2008-12-25
申请号：US12031402
申请日：2008-02-14
IPC分类号： F17C13/00
CPC分类号： F28D7/08 , F28D2021/0033 , F28F1/14 , F28F13/12
摘要： An apparatus and method for cryogenic processing comprising a chamber having a specially optimized configuration and geometry and having internal insert array of pathways and supporting elements to facilitate advanced materials processing. The pathways and supporting components can be configured by bending and positioning in different planes with bending the pathways with optimal radii and in different planes. The pathways bending radii can be within an optimal range for the size of the chamber and the angles between the pathway bending planes can be within an optimal range. The angles between the supporting components positioning planes and the pathway bending planes can be in an optimal range. The invention can also include structural supporting components that are attached at the pathway small movement points and the length of attachment can vary from about approximately zero to the full length of the supporting component. A space can be provided between pathway and supporting components or between the array and the chamber walls allowing their independent movement and product exchange
摘要翻译： 一种用于低温处理的装置和方法，包括具有特别优化的构造和几何形状的室，并具有用于促进先进材料处理的路径和支撑元件的内部插入阵列。 路径和支撑部件可以通过弯曲和定位在不同的平面中，通过弯曲具有最佳半径的路径并在不同的平面中来配置。 通道弯曲半径可以在腔室尺寸的最佳范围内，并且通道弯曲面之间的角度可以在最佳范围内。 支撑部件定位平面和路径弯曲面之间的角度可以在最佳范围内。 本发明还可以包括在路径小移动点处附接的结构支撑部件，并且连接长度可以从支撑部件的大约零到全长变化。 可以在通道和支撑部件之间或阵列与室壁之间提供空间，从而允许它们独立的移动和产品交换
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公开(公告)号：US20080118933A1
公开(公告)日：2008-05-22
申请号：US11986058
申请日：2007-11-20
CPC分类号： C12Q1/37 , A61K38/00 , C07K14/745 , C07K14/8121 , C12N9/6421 , C12P21/06 , G01N2500/00
摘要： Human α2-antiplasmin (α2AP) is the major inhibitor of the proteolytic enzyme plasmin that digests fibrin. Two forms of α2AP circulate in human plasma: a 464-residue protein, which we have termed “pro”-form, or α2APpro and an N-terminally-shortened 452-residue “activated”-form, or α2APact. The latter becomes crosslinked to fibrin by activated factor XIII about 5-fold more rapidly than α2APpro and makes fibrin resistant to digestion by plasmin. A new human plasma proteinase has been identified herein that cleaves the Pro12-Asn13 bond of α2APpro to yield α2APact. This enzyme is identified herein as Antiplasmin Cleaving Enzyme (APCE). Novel inhibitors of circulating APCE can diminish α2AP inhibitory capacity within forming fibrin or blood clots thereby making fibrin deposits or blood clots more susceptible to removal by plasmin. Patients who are susceptible to atherosclerotic plaque formation or are susceptible to developing thrombi that compromise organ function will benefit by therapies providing such inhibitors on a long term basis.
摘要翻译： 人α2 - 对映体蛋白（α2 AP）是消化纤维蛋白的蛋白水解酶纤溶酶的主要抑制剂。 两种形式的α2 AP在人血浆中循环：464残基的蛋白质，我们称之为“亲”型或α2亚基 / SUB>和N-末端缩短的452残基“活化”形式或α2亚类作用。 后者通过活化因子XIII与α2 P肽相比快速交联5倍，并使纤维蛋白对纤溶酶消化具有抗性。 本文已经鉴定了一种新的人血浆蛋白酶，其切割了α2 -ATP pro pro的Pro12-Asn13键，以产生α2亚基 。 该酶在本文中被鉴定为抗血小板裂解酶（APCE）。 循环APCE的新型抑制剂可以降低形成纤维蛋白或血凝块中的α2 AP抑制能力，从而使纤维蛋白沉积物或血块更容易被纤溶酶去除。 易受动脉粥样硬化斑块形成或容易发生危及器官功能的血栓的患者将通过长期提供这种抑制剂的疗法而受益。
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公开(公告)号：US20080086849A1
公开(公告)日：2008-04-17
申请号：US11581721
申请日：2006-10-16
申请人： James Patrick McKee
发明人： James Patrick McKee
IPC分类号： F16G11/00
CPC分类号： F16G3/00 , B65G15/00 , Y10S24/35 , Y10T24/3969 , Y10T24/44009 , Y10T24/44043 , Y10T24/45005 , Y10T24/45079
摘要： An apparatus and method are provided for clamping a belt with a quick clamping action. The apparatus and method employ an impact force applied to a clamping device that causes a clamping portion of the clamping device to be driven into clamping engagement with the belt received in a housing for the clamping device. In one form, the clamping device has a clamp actuator that includes an impact receiving end preferably disposed outside the housing and a clamp member in the housing that is driven into clamping engagement with the belt by the actuator. The preferred belt clamp has the actuator and clamp member configured so that during belt pulling operations, the clamp also self-locks onto the belt to increase the clamping force applied thereto. In another aspect, the housing preferably has wall portions of varying thickness to provide increased strength where needed while keeping the weight thereof to a minimum.
摘要翻译： 提供了一种用于以快速夹紧动作夹紧皮带的装置和方法。 该装置和方法采用施加到夹紧装置上的冲击力，该冲击力使夹紧装置的夹紧部分被驱动成与容纳在用于夹紧装置的壳体中的皮带夹紧接合。 在一种形式中，夹紧装置具有夹紧致动器，其包括优选地设置在壳体外部的冲击接收端和壳体中的夹紧构件，该夹紧构件通过致动器被驱动与带夹紧接合。 优选的皮带夹具具有致动器和夹紧构件，其构造成使得在皮带牵引操作期间，夹具还自动锁定到皮带上以增加施加到其上的夹紧力。 另一方面，壳体优选地具有不同厚度的壁部分，以在需要时提供增加的强度，同时将其重量保持在最小。
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