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1.发明授权Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein 失效使用人髓磷脂碱性蛋白质的肽类似物治疗多发性硬化症的方法公开(公告)号：US06379670B1
公开(公告)日：2002-04-30
申请号：US09378244
申请日：1999-08-19
IPC分类号： A61K3900
CPC分类号： C07K14/4713 , A61K38/00
摘要： The present invention is directed toward peptide analogs of human myelin basic protein. The peptide analog is at least seven amino acids long and derived from residues 83 to 99 of human myelin basic protein. The analogs are altered from the native sequence at least at positions 91, 95, or 97. Additional alterations may be made at other positions. Pharmaceutical compositions containing these peptide analogs are provided. The peptide analogs are useful for treating multiple sclerosis.
摘要翻译： 本发明涉及人髓磷脂碱性蛋白的肽类似物。 肽类似物长至少七个氨基酸，并衍生自人髓磷脂碱性蛋白的残基83至99。 类似物至少在91,95或97位从天然序列改变。可以在其他位置进行其它改变。 提供含有这些肽类似物的药物组合物。 肽类似物可用于治疗多发性硬化。
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2.发明授权Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein 失效使用人髓磷脂碱性蛋白质的肽类似物治疗多发性硬化症的方法公开(公告)号：US06251396B1
公开(公告)日：2001-06-26
申请号：US09137759
申请日：1998-08-20
IPC分类号： A61K3900
CPC分类号： C07K14/4713 , A61K38/00
摘要： The present invention is directed toward peptide analogs of human myelin basic protein. The peptide analog is at least seven amino acids long and derived from residues 83 to 99 of human myelin basic protein. The analogs are altered from the native sequence at least at positions 91, 95, or 97. Additional alterations may be made at other positions. Pharmaceutical compositions containing these peptide analogs are provided. The peptide analogs are useful for treating multiple sclerosis.
摘要翻译： 本发明涉及人髓磷脂碱性蛋白的肽类似物。 肽类似物长至少七个氨基酸，并衍生自人髓磷脂碱性蛋白的残基83至99。 类似物至少在91,95或97位从天然序列改变。可以在其他位置进行其它改变。 提供含有这些肽类似物的药物组合物。 肽类似物可用于治疗多发性硬化。
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