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1.发明授权Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein 失效使用人髓磷脂碱性蛋白质的肽类似物治疗多发性硬化症的方法公开(公告)号：US06379670B1
公开(公告)日：2002-04-30
申请号：US09378244
申请日：1999-08-19
IPC分类号： A61K3900
CPC分类号： C07K14/4713 , A61K38/00
摘要： The present invention is directed toward peptide analogs of human myelin basic protein. The peptide analog is at least seven amino acids long and derived from residues 83 to 99 of human myelin basic protein. The analogs are altered from the native sequence at least at positions 91, 95, or 97. Additional alterations may be made at other positions. Pharmaceutical compositions containing these peptide analogs are provided. The peptide analogs are useful for treating multiple sclerosis.
摘要翻译： 本发明涉及人髓磷脂碱性蛋白的肽类似物。 肽类似物长至少七个氨基酸，并衍生自人髓磷脂碱性蛋白的残基83至99。 类似物至少在91,95或97位从天然序列改变。可以在其他位置进行其它改变。 提供含有这些肽类似物的药物组合物。 肽类似物可用于治疗多发性硬化。
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2.发明授权Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein 失效使用人髓磷脂碱性蛋白质的肽类似物治疗多发性硬化症的方法公开(公告)号：US06251396B1
公开(公告)日：2001-06-26
申请号：US09137759
申请日：1998-08-20
IPC分类号： A61K3900
CPC分类号： C07K14/4713 , A61K38/00
摘要： The present invention is directed toward peptide analogs of human myelin basic protein. The peptide analog is at least seven amino acids long and derived from residues 83 to 99 of human myelin basic protein. The analogs are altered from the native sequence at least at positions 91, 95, or 97. Additional alterations may be made at other positions. Pharmaceutical compositions containing these peptide analogs are provided. The peptide analogs are useful for treating multiple sclerosis.
摘要翻译： 本发明涉及人髓磷脂碱性蛋白的肽类似物。 肽类似物长至少七个氨基酸，并衍生自人髓磷脂碱性蛋白的残基83至99。 类似物至少在91,95或97位从天然序列改变。可以在其他位置进行其它改变。 提供含有这些肽类似物的药物组合物。 肽类似物可用于治疗多发性硬化。
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公开(公告)号：US4610976A
公开(公告)日：1986-09-09
申请号：US527292
申请日：1983-08-29
申请人： Peter Bohlen , Frederick S. Esch , Nicholas C. Ling , Paul E. Brazeau, Jr. , Roger C. L. Guillemin
发明人： Peter Bohlen , Frederick S. Esch , Nicholas C. Ling , Paul E. Brazeau, Jr. , Roger C. L. Guillemin
CPC分类号： C07K14/60 , A61K38/00 , Y10S930/12
摘要： The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in mammals and which have the formula: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Arg-Asn-Gln-Glu-Gln-Gly-Ala-Arg-Val-Arg-Leu-Y wherein Y is OH or NH.sub.2. These peptides or biologically active fragments thereof, or analogs thereof having well-known substitutions and, or additions, as well as nontoxic salts of any of the foregoing, may be administered therapeutically to mammals, including humans, and may be used diagnostically. The peptides are useful in stimulating the release of GH and accelerating growth in warm-blooded non-human animals, particularly pigs, and in improving aquiculture.
摘要翻译： 本发明提供了非常有效刺激哺乳动物垂体GH释放的合成肽，其具有下式：H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys- Val-Leu-Gly-Gln-Leu- Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Arg-Asn-Gln-Glu -Gln-Gly-Ala-Arg-Val-Arg-Leu-Y，其中Y是OH或NH2。 这些具有众所周知的替代和/或添加的肽或其类似物或其类似物以及前述任何一种的无毒盐可以在治疗上施用于包括人在内的哺乳动物，并且可以在诊断上使用。 这些肽可用于刺激GH的释放并加速温血非人类动物，特别是猪的生长和改善水产养殖。
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公开(公告)号：US4409139A
公开(公告)日：1983-10-11
申请号：US291294
申请日：1981-08-10
IPC分类号： A61K38/00 , C07K14/575 , C07G15/00
CPC分类号： C07K14/575 , A61K38/00
摘要： A substantially purified substance has been isolated from bovine gonadal secretions which mediates pituitary hormone secretion, using an extraction and purification sequence that includes gel filtration, partition chromatography and HPLC in that order. The substance, designated gonadostatin, is a moderate-size peptide which below a threshold level selectively inhibits LRF-stimulated pituitary secretion of LH and FSH. Above a threshold level, gonadostatin generally stimulates pituitary hormone secretion.
摘要翻译： 已经从使用包括凝胶过滤，分配色谱和HPLC的提取和纯化序列的垂体激素分泌的牛性腺分泌物中分离出基本纯化的物质。 该物质指定的促性腺激素是一种低于阈值水平的中等大小的肽，选择性抑制LRF刺激的LH和FSH的垂体分泌。 高于阈值水平，促性腺激素通常会刺激垂体激素分泌。
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公开(公告)号：US5464774A
公开(公告)日：1995-11-07
申请号：US139953
申请日：1987-12-31
CPC分类号： C07K14/503 , A61K38/00
摘要： Substantially pure mammalian basic fibroblast growth factors are produced. The amino acid residue sequences of bovine and human bFGF are disclosed as well as a DNA chain encoding the polypeptide of the bovine species. By appropriately inserting a synthesized DNA chain into a cloning vector and using the cloning vector to transform cells, synthetic bovin bFGF can be obtained from transformed cell lines, both prokaryotic and eukaryotic.
摘要翻译： 产生基本纯化的哺乳动物碱性成纤维细胞生长因子。 公开了牛和人bFGF的氨基酸残基序列以及编码牛种多肽的DNA链。 通过将合成的DNA链适当地插入到克隆载体中并使用克隆载体来转化细胞，可以从原核和真核的转化细胞系获得合成的bovin bFGF。
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公开(公告)号：US5252718A
公开(公告)日：1993-10-12
申请号：US873773
申请日：1992-04-27
申请人： J. Andrew Baird , Nicholas C. Ling
发明人： J. Andrew Baird , Nicholas C. Ling
CPC分类号： C07K14/503 , A61K38/00 , Y10S930/12
摘要： Antagonists to basic fibroblast growth factor, a 146 amino acid residue polypeptide, are produced. These antagonists are generally between 10 and 45 residues in length and are characterized by their ability to interact with the FGF receptor and/or inhibit and therefore modulate endothelial and other cell growth in vitro and also in vivo. These antagonists includes the sequence of bovine basic FGF(106-115), namely Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr or a sequence having equivalent residues substituted therein. These peptides are also antagonistic to acidic FGF and other members of the family of FGF peptides. They are effective to combat FGF-promoted mitosis in melanomas and the like.
摘要翻译： 产生碱性成纤维细胞生长因子（146个氨基酸残基多肽）的拮抗剂。 这些拮抗剂的长度通常为10至45个残基，其特征在于它们与FGF受体相互作用的能力和/或抑制并因此调节体外和体内内皮和其他细胞生长。 这些拮抗剂包括牛碱性FGF（106-115）的序列，即Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr或其中具有相当残基的序列。 这些肽也与酸性FGF和FGF家族的其他成员拮抗。 它们有效地对抗FGF促进黑素瘤等有丝分裂。
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公开(公告)号：US5037805A
公开(公告)日：1991-08-06
申请号：US326151
申请日：1989-03-20
申请人： Nicholas C. Ling
发明人： Nicholas C. Ling
IPC分类号： A61K38/00 , C07K14/575
CPC分类号： C07K14/575 , A61K38/00 , Y10S424/811
摘要： Methods are disclosed for regulating ovulation or fertility in female mammals, for regulating spermatogenesis in males and for treating conditions such as endometriosis. Administration of effective amounts of an FSH-Inhibiting Protein (FSH-IP) can be used for female contraception and also for male contraception by preventing sperm production. FSH-IP, in its native form, is a glycosylated protein having an apparent molecular weight of about 50,000 Daltons (50kD) which inhibits the production of estradiol that would otherwise be stimulated by FSH in certain cells, such as granulosa cells. Antibodies to these FSH-IP proteins, preferably of monoclonal form can be produced using techniques presently known in the art and are useful for treatment to promote ovulation or superovulation in mammals, including humans and livestock.
摘要翻译： 公开了用于调节雌性哺乳动物的排卵或生育能力的方法，用于调节雄性中的精子发生和用于治疗诸如子宫内膜异位症的病症。 施用有效量的FSH抑制蛋白（FSH-IP）可用于女性避孕，也可用于通过预防精子生产进行男性避孕。 FSH-IP以其天然形式是具有约50,000道尔顿（50kD）的表观分子量的糖基化蛋白质，其抑制否则在某些细胞例如粒细胞中由FSH刺激的雌二醇的产生。 可以使用本领域目前已知的技术制备优选单克隆形式的这些FSH-IP蛋白的抗体，并且可用于促进包括人和牲畜在内的哺乳动物的排卵或超排卵的治疗。
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公开(公告)号：US4956455A
公开(公告)日：1990-09-11
申请号：US747154
申请日：1985-06-20
IPC分类号： C12N15/00 , A61K38/00 , C07K14/00 , C07K14/50 , C12N1/16 , C12N1/19 , C12N1/20 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/865 , C12R1/91
CPC分类号： C07K14/503 , A61K38/00 , Y10S530/82 , Y10S530/827 , Y10S530/839
摘要： Substantially pure bovine pituitary fibroblast growth factor, a 146 amino acid residue polypeptide, is produced. The amino acid residue sequence of bpFGF is disclosed as well as a DNA chain encoding the polypeptide. By appropriately inserting a synthesized DNA chain into a cloning vector and using the cloning vector to transform cells, synthetic bpFGF can be obtained from transformed cell lines, both prokaryotic and eukaryotic.
摘要翻译： 产生基本上纯的牛垂体成纤维细胞生长因子146个氨基酸残基多肽。 公开了bpFGF的氨基酸残基序列以及编码该多肽的DNA链。 通过将合成的DNA链适当地插入到克隆载体中并使用克隆载体来转化细胞，可以从原核和真核的转化细胞系获得合成的bpFGF。
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公开(公告)号：US4585756A
公开(公告)日：1986-04-29
申请号：US541167
申请日：1983-10-12
申请人： Paul E. Brazeau, Jr. , Peter Bohlen , Frederick S. Esch , Nicholas C. Ling , Roger C. L. Guillemin
发明人： Paul E. Brazeau, Jr. , Peter Bohlen , Frederick S. Esch , Nicholas C. Ling , Roger C. L. Guillemin
CPC分类号： C07K14/60 , A61K38/00 , Y10S930/12
摘要： The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in mammals and which have the formula: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Asn-Arg-Gln-Gln-Gly-Glu-Arg-Asn-Gln-Glu-Gln-Gly-Ala-Lys-Val-Arg-Leu-Y wherein Y is OH or NH.sub.2. These peptides or biologically active fragments thereof, or analogs thereof having well-known substitutions and/or additions, as well as nontoxic salts of any of the foregoing, may be administered therapeutically to mammals, including humans, and may be used diagnostically. The peptides are useful in stimulating the release of GH so as to accelerate growth in warm-blooded non-human animals, particularly cattle, and/or to increase the production of milk in lactating cows, and also in improving aquiculture.
摘要翻译： 本发明提供了非常有效刺激哺乳动物垂体GH释放的合成肽，其具有下式：H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys- Val-Leu-Gly-Gln-Leu- Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Asn-Arg-Gln-Gln-Gly-Glu-Arg-Asn-Gln-Glu -Gln-Gly-Ala-Lys-Val-Arg-Leu-Y，其中Y是OH或NH2。 具有众所周知的取代和/或添加的这些肽或其类似物或其类似物以及前述任何一种的无毒盐可以在治疗上施用于哺乳动物，包括人，并且可以在诊断上使用。 这些肽可用于刺激GH的释放，以加速温血非人类动物，特别是牛的生长，和/或增加哺乳期牛的奶的产量，以及改善水产养殖。
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公开(公告)号：US4316891A
公开(公告)日：1982-02-23
申请号：US159801
申请日：1980-06-14
IPC分类号： A61K38/00 , C07K14/655 , A61K37/00 , C07C103/52
CPC分类号： C07K14/6555 , A61K38/00 , Y10S514/806 , Y10S930/16
摘要： 28-member residue and 25-member residue peptides have been synthesized containing the tetradecapeptide somatostatin that are more potent than somatostatin. Somatostatin-28 has the formula: ##STR1## The three N-terminal amino acid residues are absent in somatostatin-25. Somatostatin-28 or somatostatin-25 or a pharmaceutically acceptable addition salt thereof, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals in the same manner as somatostatin.
摘要翻译： 已经合成了含有比生长抑素更有效的十四肽生长抑素的28个残基和25个残基的肽。 生长抑素-28具有下式：H-Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys- + TR三个N末端氨基酸残基 在生长抑素-25中不存在。 分散在药学上可接受的液体或固体载体中的生长抑素-28或生长抑素-25或其药学上可接受的加成盐可以以与生长抑素相同的方式施用于哺乳动物。
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