公开(公告)号：US20090192071A1

公开(公告)日：2009-07-30

申请号：US12239645

申请日：2008-09-26

申请人： Michael GOLD ,  Mitchel Goldman ,  Scott Lundahl ,  Paul Sowyrda

发明人： Michael GOLD ,  Mitchel Goldman ,  Scott Lundahl ,  Paul Sowyrda

IPC分类号： A61K38/00 ,  A61P37/00 ,  A61K31/198 ,  A61M37/00

CPC分类号： A61N5/062

摘要： Methods of enhancing the efficacy and safety of treatment with immuno-modulating agents are provided. The inventive methods combine treatment with immuno-modulating agents with photodynamic therapy (PDT). PDT can be administered before, during or after administration of the immuno-modulating agent. Combination therapy achieves at least the same efficacy as immuno-modulatory therapy in less time, with less immuno-modulating agent and fewer side-effects.

摘要翻译： 提供了增强免疫调节剂治疗功效和安全性的方法。 本发明的方法将免疫调节剂与光动力疗法（PDT）联合起来。 可以在给予免疫调节剂之前，期间或之后施用PDT。 联合治疗在较少时间内达到与免疫调节治疗相同的功效，免疫调节剂少，副作用少。

公开(公告)号：US20090275933A1

公开(公告)日：2009-11-05

申请号：US12435184

申请日：2009-05-04

申请人： Brian D. Zelickson ,  Thomas Dressel ,  Stephen M. Tobin ,  Paul Sowyrda ,  Steven Woolfson

发明人： Brian D. Zelickson ,  Thomas Dressel ,  Stephen M. Tobin ,  Paul Sowyrda ,  Steven Woolfson

IPC分类号： A61B18/20

CPC分类号： A61B18/22 ,  A61B2018/00464 ,  A61B2018/2222 ,  A61B2018/2266 ,  A61B2018/2272

摘要： A laser energy soft tissue aspiration device comprises a cannula defining an aspiration lumen and having one or more aspiration inlet ports at a distal end. A laser energy transmission guide delivers laser energy from the proximal end of the cannula to the distal end which can be inserted to a tissue removal site within a patient. Reciprocating longitudinal motion of the cannula along with suction provided within the lumen can cause soft tissue to be suctioned into the lumen for removal. Laser energy contained within the lumen and directed by an optical delivery system can ablate soft tissue pulled within the lumen. The optical delivery system can further protect the terminal point of the laser energy transmission guide by isolating it, or removing it from the flow of aspirated tissue.

摘要翻译： 激光能量软组织抽吸装置包括限定抽吸腔并且在远端具有一个或多个抽吸入口的套管。 激光能量传输引导件将激光能量从套管的近端输送到可以插入到患者体内的组织移除部位的远端。 插管的往复纵向运动以及设在内腔内的抽吸可导致软组织被吸入管腔以便移除。 腔内所包含的并由光学传送系统引导的激光能量可以消融在内腔内拉动的软组织。 光学传输系统可以通过隔离激光能量传输引导件的终点或将其从抽吸的组织的流中移除来进一步保护终端点。

公开(公告)号：US20090287196A1

公开(公告)日：2009-11-19

申请号：US12435191

申请日：2009-05-04

申请人： Brian D. Zelickson ,  Thomas Dressel ,  Stephen M. Tobin ,  Paul Sowyrda ,  Steven Woolfson

发明人： Brian D. Zelickson ,  Thomas Dressel ,  Stephen M. Tobin ,  Paul Sowyrda ,  Steven Woolfson

IPC分类号： A61B18/20

CPC分类号： A61B18/22 ,  A61B2018/00464 ,  A61B2018/2222 ,  A61B2018/2266 ,  A61B2018/2272

摘要： A laser energy soft tissue aspiration device comprises a cannula defining an aspiration lumen and having one or more aspiration inlet ports at a distal end. A laser energy transmission guide delivers laser energy from the proximal end of the cannula to the distal end which can be inserted to a tissue removal site within a patient. Reciprocating longitudinal motion of the cannula along with suction provided within the lumen can cause soft tissue to be suctioned into the lumen for removal. Laser energy contained within the lumen and directed by an optical delivery system can ablate soft tissue pulled within the lumen. The optical delivery system can further protect the terminal point of the laser energy transmission guide, from which, the laser energy can be delivered.

公开(公告)号：US20090275932A1

公开(公告)日：2009-11-05

申请号：US12435179

申请日：2009-05-04

申请人： Brian D. Zelickson ,  Thomas Dressel ,  Stephen M. Tobin ,  Paul Sowyrda ,  Steven Woolfson

发明人： Brian D. Zelickson ,  Thomas Dressel ,  Stephen M. Tobin ,  Paul Sowyrda ,  Steven Woolfson

IPC分类号： A61B18/22

CPC分类号： A61B18/22 ,  A61B2018/00464 ,  A61B2018/2222 ,  A61B2018/2266 ,  A61B2018/2272

摘要： A laser energy soft tissue aspiration device comprises a cannula defining an aspiration lumen and having one or more aspiration inlet ports at a distal end. A laser energy transmission guide delivers laser energy from the proximal end of the cannula to the distal end which can be inserted to a tissue removal site within a patient. Reciprocating longitudinal motion of the cannula along with suction provided within the lumen can cause soft tissue to be suctioned into the lumen for removal. Laser energy contained within the lumen and directed by an optical delivery system can ablate soft tissue pulled within the lumen. The optical delivery system can further protect the terminal point of the laser energy transmission guide, from which, the laser energy can be delivered.

摘要翻译： 激光能量软组织抽吸装置包括限定抽吸腔并且在远端具有一个或多个抽吸入口的套管。 激光能量传输引导件将激光能量从套管的近端输送到可以插入到患者体内的组织移除部位的远端。 插管的往复纵向运动以及设在内腔内的抽吸可导致软组织被吸入管腔以便移除。 腔内所包含的并由光学传送系统引导的激光能量可以消融在内腔内拉动的软组织。 光学传输系统可以进一步保护激光能量传输引导件的终点，激光能量从该点传送。

公开(公告)号：US20050267213A1

公开(公告)日：2005-12-01

申请号：US11030311

申请日：2005-01-07

申请人： Michael Gold ,  Mitchel Goldman ,  Scott Lundahl ,  Paul Sowyrda

发明人： Michael Gold ,  Mitchel Goldman ,  Scott Lundahl ,  Paul Sowyrda

IPC分类号： A61K31/198 ,  A61N5/06

CPC分类号： A61N5/062

摘要： Methods of enhancing the efficacy and safety of treatment with immuno-modulating agents are provided. The inventive methods combine treatment with immuno-modulating agents with photodynamic therapy (PDT). PDT can be administered before, during or after administration of the immuno-modulating agent. Combination therapy achieves at least the same efficacy as immuno-modulatory therapy in less time, with less immuno-modulating agent and fewer side-effects.

摘要翻译： 提供了增强免疫调节剂治疗功效和安全性的方法。 本发明的方法将免疫调节剂与光动力疗法（PDT）联合起来。 可以在给予免疫调节剂之前，期间或之后施用PDT。 联合治疗在较少时间内达到与免疫调节治疗相同的功效，免疫调节剂少，副作用少。